Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)
Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)
Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)
Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion (LSIL) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)
Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion (LSIL) Esiastemuutokset High-grade squamous intraepithelial lesion (HSIL) Levyepiteelikarsinooma ja sen variantit
Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion Esiastemuutokset High-grade squamous intraepithelial lesion (CIN2) High-grade squamous intraepithelial lesion (CIN3) Levyepiteelikarsinooma ja sen variantit
Levyepiteeli Infektiiviset muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)
Cumulative incidence of cervical intraepithelial neoplasia grade 3 and cancer ( CIN3) over a 10- year period in 20 514 women according to oncogenic human papillomavirus (HPV) status at enrollment. HPV 16 HPV 18 hrhpv + HPV 16/18 - hrhpv - Khan M J et al. JNCI J Natl Cancer Inst 2005;97:1072-1079 The Author 2005. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org.
HPV16/18? CIN1 CIN2 CIN3
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical (usual) type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma NOS Gastric (including MDA) Intestinal Signet-ring cell Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma
2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma NOS Gastric (including MDA) Intestinal Signet-ring cell Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma Adenocarcinoma admixed with neuroendocrine carcinoma