Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm)

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Arto Jokinen
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2 Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)

3 Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)

4 Levyepiteeli Lievät muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)

5 Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion (LSIL) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)

6 Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion (LSIL) Esiastemuutokset High-grade squamous intraepithelial lesion (HSIL) Levyepiteelikarsinooma ja sen variantit

7 Levyepiteeli Infektiiviset muutokset Low-grade squamous intraepithelial lesion Esiastemuutokset High-grade squamous intraepithelial lesion (CIN2) High-grade squamous intraepithelial lesion (CIN3) Levyepiteelikarsinooma ja sen variantit

8 Levyepiteeli Infektiiviset muutokset Atypia condylomatosa/litteä kondylooma CIN 1 (lievä dysplasia) Esiastemuutokset CIN 2 (= keskivahva dysplasia) CIN 3 (= vahva dysplasia ja carcinoma in situ) Pinnallisesti invasoiva levyepiteelikarsinooma (Stage IA1; invaasio < 3 mm, laajuus < 7 mm) Levyepiteelikarsinooma ja sen variantit (Stage > IA2)

9 Cumulative incidence of cervical intraepithelial neoplasia grade 3 and cancer ( CIN3) over a 10- year period in women according to oncogenic human papillomavirus (HPV) status at enrollment. HPV 16 HPV 18 hrhpv + HPV 16/18 - hrhpv - Khan M J et al. JNCI J Natl Cancer Inst 2005;97: The Author Published by Oxford University Press. All rights reserved. For Permissions, please journals.permissions@oupjournals.org.

10 HPV16/18? CIN1 CIN2 CIN3

11 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

12 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

13 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

14 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

15 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Mucinous adenocarcinoma Endocervical (usual) type Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

16 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma Intestinal Signet-ring cell Minimal deviation Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

17 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma NOS Gastric (including MDA) Intestinal Signet-ring cell Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma

18 2003 WHO Classification of Adenocarcinoma of Cervix Glandular dysplasia Adenocarcinoma in situ Early invasive adenocarcinoma Adenocarcinoma Endocervical (usual) type Mucinous adenocarcinoma NOS Gastric (including MDA) Intestinal Signet-ring cell Villoglandular Endometrioid adenocarcinoma Clear cell adenocarcinoma Serous adenocarcinoma Mesonephric adenocarcinoma Adenocarcinoma admixed with neuroendocrine carcinoma

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