lpar1 IPB004065, IPB002277, and IPB Restriction Enyzme Differences from REBASE Gained in Variant Lost from Reference

Transkriptio

1 lpar1 IPB465, IPB2277, and IPB5385 Genomic Sequence Coding Sequence For help interpreting these results, view the PARSENP Introduction page. # View On Sequence Nucleotide Change Effect Restriction Enyzme Differences from REBASE Gained in Variant Lost from Reference PSSM Difference SIFT Score Description Zygosity 1 G C C584T N28= BsmI L1-44 Homo 2 G C A633G I45V TspDTI S1-44 Homo 3 G C T637A M46K AluI, CviJI 4 G C A67G Y57C CviRI, MwoI, SfaNI 5 G C T718C L73P BseYI, NspBII L2-67 Homo L3-54 Homo MaeI L1-39 Homo 6 G C T75C Y84H L1-31 Homo 7 G C T75C Y84H L1-82 Homo 8 G C T76G L87W BsrI, FokI L1-56 Homo 9 G C C85T NlaIII, T12M NspI BsaAI, MaeII, PmaCI 18.. S1-25 Homo 1 G C G89A W13* L3-6 Homo 11 G C C83T I11= ClaI, TaqI L3-44 Homo 12 G C A851G S117= SecI BspMI, BseMII, DdeI S1-29 Homo

2 13 G C C918T R14C BspMI, CviRI AciI, FauI L3-78 Homo 14 G C T922C M141T BsiI NlaIII L3-58 Homo 15 G C A12G I174V AccI, BcefI, MjaIV L1-55 Homo 16 G C A136T N179I L2-43 Homo 17 G C A156T N186Y AluI, CviJI 18 G C G111A V21M 19 G C C1177A,G1178A S226* 2 G C C1177A,G1178A S226* 21 G C T1231C I244T MslI, NlaIII, TspDTI Bpu1I, DdeI Bpu1I, DdeI MaeIII, Tsp45I, Tsp4CI L3-4 Homo L2-94 Homo AvaI L2-63 Homo AvaI L3-19 Homo L1-4 Homo 22 G C T1241G G247= L3-89 Homo 23 G C T1253G N251K ApoI L2-14 Homo Download Tab-Separated table View Variants on 3D Structure No protein homology model was submitted. You may add one using any or all of the fields below. Blocks Families: Blocks File: Sequence Alignment: Choose File Choose File no file selected no file selected Redo analysis with homology model -OR- Reverse PSI-Blast/SIFT for Models Genomic Sequence attcacagatgtgtttaatagcttatttcagagttagaagcccaagctacagtctgccattgtccttgtttg 72

3 tgtttatgcaggctcctgtttacttggcctttcctggtgtacattatgaggtaacatgctaataaaacaggg 144 ccagatggaaattgcatgacactactttaagcctgtgaaacatatcactagattctgaatttctgttgagtt 216 aaacgattgttgcgtctataatacgcttttattaggcatttccatggaggtatcatgcattttaaatgatct 288 catgcactgtgacagaagatatgtcaacagtttatttcaaaataatgattcaattatttttcctgtggctat 36 aaatcaattgacttcaatgcatgtgggtggctactttgtgtggcagtaaaattaaattattattattccatt 432 M 1 aattatgcaaaacatgttatgacaaaccgctttttgtatctttatttttcagaaacagacctttcagg atg 53 IPB465A (7.4e-14) IC 3.8 D D R Q C Y Y N E T I A F F Y N R S 19 gat gat aga caa tgc tac tac aac gaa acc ata gcc ttt ttt tac aat cgt agt 557 IPB2277B (2.7e-2) IC 4.32 Q K Y L A T E W N A V S K L V M G L 37 cag aag tat ctg gcc aca gaa tgg aac gct gta agc aag cta gtc atg gga ctt 611 tn28=[1] G I T V C I F I M L A N L L V M V A 55 ggg att aca gta tgc att ttc ata atg cta gca aac ctg ctg gtg atg gtg gcc 665 gi45v[2] am46k[3] I Y I N R R F H F P I Y Y L M A N L 73 atc tac atc aac cgc cgc ttt cac ttt cca atc tac tat cta atg gct aac cta 719 gy57c[4] cl73p[5] A A A D F F A G L A Y F Y L M F N T 91 gca gcc gcg gac ttc ttt gca gga ctt gcc tat ttc tac ttg atg ttt aac acg 773 cy84h[6] gl87w[8] cy84h[7] IPB2277C (1.4e-14) IC 4.32 G P N T R R L T V S T W L L R Q G L 19 ggg ccc aat aca aga agg cta acg gtt agc acg tgg ttg ctt cga caa ggc ctc 827

4 tt12m[9] aw13*[1] I D T S L T A S V A N L L A I A I E 127 atc gat aca agc ctt aca gcc tca gtt gct aac ttg cta gct ata gcc att gag 881 ti11=[11] gs117=[12] IPB2277D (2.4e-22) IC 4.32 R H I T V F R M Q L H T R M S N R R 145 cgc cac ata act gtg ttc cgc atg cag ctc cat acc cgc atg agc aat cgg agg 935 tr14c[13] cm141t[14] V V V V I V I I W T M S I V M G A I 163 gta gtt gtg gtt ata gtc atc atc tgg acc atg tct atc gtc atg ggg gct att 989 IPB2277E (4.5e-13) IC 4.32 P S V G W N C I C A I D T C S N M A 181 cct agc gtg ggc tgg aac tgc atc tgc gcc ata gac act tgt tcc aat atg gcc 143 gi174v[15] tn179i[16] P L Y S N S Y L G F W A I F N L V T 199 cca ctc tac agc aac tcg tac ctg ggc ttc tgg gca atc ttt aac ctg gtg acc 197 tn186y[17] IPB2277F (1.5e-19) IC 4.32 F V V M V V L Y A H I F M Y V R Q R 217 ttc gtg gtg atg gtc gta ctt tat gca cac ata ttt atg tat gtg cgt cag cgg 1151 av21m[18] T M R M S R H S S G Q R R N R D T M 235 acc atg agg atg tcc cgg cac agc tcg ggt caa cgg cgt aac agg gat act atg 125 aas226*[19] aas226*[2] M S L L K T V V I V L G K C S N N F 253 atg agc ttg ctg aaa act gtc gtg att gta ttg ggt aag tgc tcc aat aat ttt 1259 ci244t[21] gg247=[22] gn251k[23] C I F I I N P L G S A C F K T I I W 271 tgt att ttt atc att aat cct tta ggc tct gca tgc ttc aag act att atc tgg 1313 K F V V N L N K C *

5 aag ttt gta gtt aac ttg aac aaa tgc tga tgtaagtttcagaataagctggggtcatactt 1375 tattttgatggtccgtttgttgcattgcatctacatgtcaactaattttcattagattataagtaaactgtt 1447 aggttagggttagggtttagtgtacgttgacatgtacttgcaaagtttcttctagtcagttaatgtctgttg 1519 aaggagcagtatcaacagatattaagctgacagtccactaatactcaaatggatcatcaaaataaagtgtca 1591 ccttagctggttcaaatgtgtttgattatcattagagaaaaaaaaaaaaacagacttgtaggatagtggacc 1663 tttgagtgcagaattcagtttaagttaaacatgtgttccaacagaattaacacaacatttctagtaatacta 1735 taattctacagtataaacgaactttatagcaaatgtttgcatttttttaaatccccttgagtattacggtac 187 tatttttaaagggccatgaaaccccctcgtttcagc 1843 Coding Sequence IPB465A (7.4e-14) IC 3.8 M D D R Q C Y Y N E T I A F F Y N R 18 atg gat gat aga caa tgc tac tac aac gaa acc ata gcc ttt ttt tac aat cgt 54 IPB2277B (2.7e-2) IC 4.32 S Q K Y L A T E W N A V S K L V M G 36 agt cag aag tat ctg gcc aca gaa tgg aac gct gta agc aag cta gtc atg gga 18 tn28=[1] L G I T V C I F I M L A N L L V M V 54 ctt ggg att aca gta tgc att ttc ata atg cta gca aac ctg ctg gtg atg gtg 162 gi45v[2] am46k[3] A I Y I N R R F H F P I Y Y L M A N 72

6 gcc atc tac atc aac cgc cgc ttt cac ttt cca atc tac tat cta atg gct aac 216 gy57c[4] L A A A D F F A G L A Y F Y L M F N 9 cta gca gcc gcg gac ttc ttt gca gga ctt gcc tat ttc tac ttg atg ttt aac 27 cl73p[5] cy84h[6] gl87w[8] cy84h[7] IPB2277C (1.4e-14) IC 4.32 T G P N T R R L T V S T W L L R Q G 18 acg ggg ccc aat aca aga agg cta acg gtt agc acg tgg ttg ctt cga caa ggc 324 tt12m[9] aw13*[1] L I D T S L T A S V A N L L A I A I 126 ctc atc gat aca agc ctt aca gcc tca gtt gct aac ttg cta gct ata gcc att 378 ti11=[11] gs117=[12] IPB2277D (2.4e-22) IC 4.32 E R H I T V F R M Q L H T R M S N R 144 gag cgc cac ata act gtg ttc cgc atg cag ctc cat acc cgc atg agc aat cgg 432 tr14c[13] cm141t[14] R V V V V I V I I W T M S I V M G A 162 agg gta gtt gtg gtt ata gtc atc atc tgg acc atg tct atc gtc atg ggg gct 486 IPB2277E (4.5e-13) IC 4.32 I P S V G W N C I C A I D T C S N M 18 att cct agc gtg ggc tgg aac tgc atc tgc gcc ata gac act tgt tcc aat atg 54 gi174v[15] tn179i[16] A P L Y S N S Y L G F W A I F N L V 198 gcc cca ctc tac agc aac tcg tac ctg ggc ttc tgg gca atc ttt aac ctg gtg 594 tn186y[17] IPB2277F (1.5e-19) IC 4.32 T F V V M V V L Y A H I F M Y V R Q 216 acc ttc gtg gtg atg gtc gta ctt tat gca cac ata ttt atg tat gtg cgt cag 648 av21m[18] R T M R M S R H S S G Q R R N R D T 234 cgg acc atg agg atg tcc cgg cac agc tcg ggt caa cgg cgt aac agg gat act 72 aas226*[19] aas226*[2]

7 M M S L L K T V V I V L G K C S N N 252 atg atg agc ttg ctg aaa act gtc gtg att gta ttg ggt aag tgc tcc aat aat 756 ci244t[21] gg247=[22] gn251k[23] F C I F I I N P L G S A C F K T I I 27 ttt tgt att ttt atc att aat cct tta ggc tct gca tgc ttc aag act att atc 81 W K F V V N L N K C * tgg aag ttt gta gtt aac ttg aac aaa tgc tga 843