ips ips ips Olle Lindvall ips ips

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2 1 173 Olle Lindvall 2002 ips ips ips ips ips 1) ips

3 2) 3) 4) 1) (Oki et al.: Stem Cells 30: , 2012; Falk et al.: PLoS One 7:e29597) ips ips 2) 1) 1 6 4% (PFA) (Mine et al.: Neurosurgery64: , 2009) 3) ips 4) 1)-3)(Oki et al.: Stem Cells 30: , 2012; Mine et al.: Neurobiol Dis 52: , 2013) 2)neurosphere TSC BrdU 5) 2-8 ips ips 4 6) ips 7) 2)5) EGFP ips 1 9) 8) ips therapeutic stem cells, TSCs 38C2 mouse ips cellsnanog GFP IRES Puro lentivirus humanized and CpG-free HSV1tk mouse GCV human ips cells (253G1integration-free 1210B2) humanized and CpG-free HSV1tk ipsc GCV EBs neurosphere ips-nsc 2 nd Tet-on system HSVtk human ipscs NSCs TSC

4 (middle cerebral artery occlusion, MCAO) steppingtest cylinder test stair case test TSC In vitro mouse ips cell TSC-NSC U87, U251 GCV 7 human ips-nsc TSC bystander killing effect In vivo U87, U251 HG U87 human ips-nsc TSC GCV 19.3 (n=6)33.8 n=6 IVIS (in vivo imaging system) ips 1 Arai N, Inaba M, Ichijo K, Kagami H, Mine Y. Thyrotropin-producing pituitary adenoma simultaneously existing with Graves disease: a case report. J Med Case Rep 11:9, doi: /s Intra-arterial infusion of fusdil hydrochloride improves neurological deterioration by severe aneurysmal SAHSTROKE

5 Direct clipping for intracranial aneurysm by 3D Exoscope Usefulness of virtual 3D neuroendoscopy combined with neuronavigation in evacuation of intracranial hematoma Intra-arterial infusion of fasudil hydrochloride improves neurological deterioration by severe aneurysmal SAH Mine Y, Yoshida K, Murakami H, Ishihara M, Kagami H, Inaba M. 3D simulation and neuronavigation for the surgery of paraclinoid aneurysm might contribute to the safe direct surgery and the preservation of visual function. 7 th World Congress of the World Federation of Skull Base Surgery Intra-arterial infusion of fasudil hydrochloride improves deteriorations by severe aneurysmal subarachnoid hemorrhage STROKE D simulation and neuronavigation for the surgery of paraclinoid aneurysms. STROKE Usefulness of virtual 3D neuroendoscopy combined with neuronavigation in evacuation of intracranial hematoma Combination therapy of cilostazol and intra-arterial infusion of fasudil hydrochloride might improve the neurological deteriorations by severe aneurysmal subarachnoid hemorrhage D simulation and neuronavigation for the surgery of paraclinoid aneurysms Inoue S, Mine Y, Hara K, Iwai H, Komaki Y, Tsukada H, Nakamura M, Okano HJ, Yoshida K, Okano H. Development of less invasive transient middle cerebral artery occulusion model on common marmoset and transplantation of NS/PCs. The 13 th annual meeting of ISSCR Stockholm, Sweden. Mine Y, Kanai R, Miyoshi H, Okano H, Toda M. Establishment of therapeutic stem cells derived from induced pluripotent stem cells for malignant glioma. The 13 th annual meeting of ISSCR Stockholm, Sweden. Mine Y, Tatarishvili J, Oki K, Mooni E, Kokaia Z, Lindvall O. Grafted human neural stem cells enhance several steps of endogenous neurogenesis and improve behavioural recovery after middle cerebral

6 after occlusion in rats Mine Y. Ishimori H., Murakami H., Nishimoto M., Kagami H., Inaba M., Ishihara M. Preservation of visual function the operation of paraclinoid aneurysms. The 25 th annual meeting of North American Skull Base Society Tampa, FL, U.S.A. Experiences of virtual 3D neuroendoscopy Treatment for cerebral venous sinus thrombosis with hemorrhagic infarction. Poster presentation Unruptured ACA aneurysm in patient with amyotrophic lateral sclerosis case report JALCITY Prevention of visual function in the operation of paraclinoid aneurysms Experiences of virtual 3D neuroendoscope Management and diagnosis of cerebral venous (sinus) thrombosis (CVT) case report-. Oral presentation