CURRICULUM VITAE. Department of Neurosurgery Kuopio University Hospital

1 CURRICULUM VITAE Name: Current position: Arto Immonen Neurosurgeon Department of Neurosurgery Kuopio University Hospital EDUCATION M.D., University of Kuopio, 1989 Speciality in Neurosurgery 1999 Ph.D., University of Eastern Finland 2010 PROFESSIONAL ACTIVITIES During 1989-1994 served as a general practitioner at rural health centre for 9 months and then at District Hospital of Porvoo as a resident in general surgery (6 months), anaesthesia (2 years) and obstetrics and gynaecology (2 years and 6 months). Resident in neurosurgery at Kuopio University Hospital during 1995-1999 and a specialist in neurosurgery since 1999. MEMBERSHIPS The Finnish Medical Association The Finnish Medical Society Duodecim The Finnish Neurosurgical Society The Scandinavian Neurosurgical Society The European Association for Pediatric Neurosurgery The Board of Co-operative Bank of Tuusniemi, Finland (2005-) The Executive Committee of Finland Optimist Dinghy Association 2005-06 Ph.D. Thesis 24.04.2010: Surgical treatment of refractory temporal lobe epilepsy: Preoperative evaluation and seizure outcome

2 LIST OF PUBLICATIONS Peer reviewed original publications 1. Sandmair AM, Loimas S, Puranen P, Immonen A, Kossila M, Puranen M, Hurskainen H, Tyynelä K, Turunen M, Vanninen R, Lehtolainen P, Paljärvi L, Johansson R, Vapalahti M,Ylä-Herttuala S. Thymidine kinase gene therapy for human malignant glioma using replication- deficient retroviruses or adenoviruses. Human Gene Therapy 11:2197-2205, 2000. Impact 4.965. 2. Jutila L, Immonen A, Partanen K, Partanen J, Mervaala E, Ylinen A, Alafuzoff I, Paljärvi L, Karkola K, Vapalahti M and Pitkänen A. Neurobiology of epileptogenesis in the temporal lobe. Advances and Technical Standards in Neurosurgery 27: 3-22, 2002. 3. Jutila L, Immonen A, Mervaala E, Partanen P, Partanen K, Puranen M, Kälviäinen R, Alafuzoff I, Hurskainen H, Vapalahti M and Ylinen A. Long- term outcome of temporal lobe epilepsy surgery: Analyses of 140 consecutive patients. Journal of Neurology, Neurosurgery & Psychiatry 73(5): 486-494, 2002. Impact 3.033. 4. Immonen A, Jutila L, Könönen M, Mervaala E, Partanen J, Puranen M, Rinne J, Ylinen A and Vapalahti M. 3- D Reconstructed Magnetic Resonance Imaging in Localization of Subdural EEG Electrodes. Case illustration. Epilepsy Research 54: 59-62, 2003. Impact 2.43. 5. Immonen A, Jutila L, Kälviäinen R, Mervaala E, Partanen K, Partanen J, Vanninen R, Ylinen A, Alafuzoff I, Paljärvi L, Hurskainen H, Rinne J, Puranen M and Vapalahti M. Preoperative clinical evaluation, outline of surgical technique and outcome in temporal lobe epilepsy. Advances and Technical Standards in Neurosurgery: vol 29, pp 88-124, 2004. 6. Immonen A, Vapalahti M, Tyynelä K, Hurskainen H, Sandmair A, Vanninen R, Langford G, Ylä-Herttuala S. AdvHSV-tk Gene Therapy with Intravenous Ganciclovir Improves Survival in Human Malignant Glioma: A Randomised, Controlled Study. Molecular Therapy 10(5) 967-972, 2004. Impact 6.125. 7. Pirttilä T, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E and Pitkänen A. Cystatin C expression is associated with granule cell dispersion in TLE. Annals of Neurology Aug 58(2):211-23, 2005. Impact 8.097. 8. Böhm J, Immonen A, Riikonen P, Vanninen R and Alafuzoff I. Case report: Central neurocytoma and leukaemia. Human Pathology 37,488-492, 2006. Impact 2.550. 9. Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R and Pitkänen A. Increased expression of caspase 2 in experimental and human temporal lobe epilepsy. NeuroMolecular Medicine, 2007. Impact 4.070

3 10. Wirth T, Hedman M, Mäkinen K, Manninen H, Immonen A, Vapalahti M and Ylä- Herttuala S. Safety of plasmid/liposomes and virus vectors in clinical gene therapy. Current Drug Safety, vol 1, 253-257, 2006. 11. Immonen A, Jutila L, Muraja- Murro A, Mervaala E, Äikiä M, Lamusuo S, Kuikka J, Vanninen E, Alafuzoff I, Ikonen A, Vanninen R, Vapalahti M and Kälviäinen R. Long-Term Epilepsy Surgery Outcomes in Patients with MRI-negative Temporal Lobe Epilepsy. Epilepsia 2010 Nov;51(11):2260-9. Impact 4.052 12. Karamanakos P, Jaaskelainen J, Alafuzoff I, Pirinen E, Vanninen R, Silvennoinen S, Sankilampi U, Immonen A. Malignant giant cell tumour in the posterior fossa of a newborn. J Neurosurg Pediatrics 5:277-282, 2010 13. Säisänen L, Könönen M, Julkunen P, Määttä S, Vanninen R, Immonen A, Jutila L., Kälviäinen R., Mervaala E. Non-invasive preoperative localization of primary motor cortex in epilepsy surgery by navigated transcranial magnetic stimulation. Epilepsy Res Dec;92(2-3):134-44, 2010. 14. Kupila L, Jutila L, Immonen A, Vanninen R, Mervaala E, Paetau A, Luostarinen L, Kälviäinen R. Late-onset Rasmussen s encephalitis and long-term remission. Epileptic Disord. 13(1):88-91, 2011. 15. Jutila L, Aikiä M, Immonen A, Mervaala E, Alafuzoff I, Kälviäinen R. Long-term memory performance after surgical treatment of unilateral temporal lobe epilepsy (TLE). Epilepsy Res. Sep;108(7):1228-37, 2014. 16. Huttunen J, Kurki M, von und zu Fraunberg M, PhD, Koivisto T, Ronkainen, Rinne J, Jääskeläinen JE, Kälviäinen R, Immonen A. Epilepsy after aneurysmal subarachnoid hemorrhage in 876 patients a population based longterm follow-up study. Neurology Jun 2;84(22):2229-37, 2015. 17. Saavalainen T, Jutila L, Mervaala E, Kälviäinen R, Vanninen R, Immonen A. Temporal anteroinferior encephalocele: An under-recognized etiology of temporal lobe epilepsy? Neurology 2015 18. Martikainen M, Niittykoski M, von und zu Fraunberg M, Immonen A, Koponen S, van Geenen M, Vähä-Koskela M, Ylösmaäki E, Saksela K and Hinkkanen A. MicroRNA-attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma. Journal of Virology 2015 19. Säisänen L, Julkunen P, Kemppainen S, Danner N, Immonen A, Mervaala E, Määttä S, Muraja-Murro A, Könönen M. Locating and outlining the cortical motor representation areas of facial muscles with navigated transcranial magnetic stimulation. Neurosurgery 2015

4 Domestic medical publications 1. Kälviäinen R, Jutila L, Herrgård E, Mervaala E, Partanen J, Immonen A ja Matti Vapalahti. Ohimolohkoepilepsian leikkaushoito kannattaa (Surgical treatment of temporal lobe epilepsy is beneficial). Duodecim 119: 1021-2, 2003. 2. Muotka M, Jutila L, Gaily E, Roivainen R, Herrgård E, Putkonen P, Granström, Ylinen A, Immonen A, Blomstedt G, Kälviäinen R. Epilepsiakirurgia Suomessa vuosina 1991-2005. (Epilepsy surgery in Finland during 1991-2005). Suomen Lääkärilehti, 2008. 3. Immonen A, Kälviäinen R, Gaily E ja Blomstedt G. Kuka hyötyy epilepsiakirurgiasta? (Who will benefit from epilepsy surgery?) Duodecim 2008;124(20):2383-91 4. Mervaala E, Mäkinen R, Peltola J, Eriksson K, Jutila L, Immonen A. Video-EEG epilepsian diagnostiikassa, milloin, miksi? (Video-EEG as a diagnostic tool in epilepsy, when and why?) Duodecim 2009;125:2514-20. 5. Karppinen A, Oinas M, Helen P, Vuorinen V, Immonen A, Koponen S, Salokorpi N, Serlo W. Hydrokefalussuntti ja sen ongelmat. (Shunts and related complications) CP-lehti 2012:4. 6. Kälviäinen R, Ansakorpi H, Flander S, Immonen A, Keränen T, Kivistö J, Peltola J. Käypä hoito suositus: Epilepsia (aikuiset) (Update on Current Care Guideline: epilepsies (adult)). Duodecim.2014;130(7):748-9. 7. Saavalainen T, Jutila L, Mervaala E, Kälviäinen R, Vanninen R, Immonen A. Temporal anteroinferior encephalocele: An under-recognized etiology of temporal lobe epilepsy? Duodecim 2015 Chapters of domestic medical books 1. Immonen A, Vapalahti M. Aivovammat (Brain Injury). Käytännön neurologiaa (Practical Neurology), Recallmed. 1999. 2. Immonen A, Luukkonen M and Vapalahti M. Akuutit aivovammat (Acute brain injuries in children). Lastenneurologia (Pediatric Neurology), Duodecim 2004. 3. Blomstedt G, Immonen A, Heikkinen E, Pohjola J, Jääskeläinen JE. Funktionaalinen neurokirurgia (Functional neurosurgery). Kirurgia (Surgery) Toim. Peter J. Roberts, Esko Alhava, Krister Höckerstedt, Ari Leppäniemi. Duodecim 2009. 4. Jääskeläinen JE, von und zu Fraunberg, Huttunen J, Immonen A, Leinonen V. Neuropalliatiivinen hoito ja neuromodulaation invasiiviset menetelmät (Neuropalliative treatment and invasive methods in neuromodulation). Palliatiivinen hoito. Duodecim 2015. In press.

5 INTERNATIONAL COURSES AND FELLOWSHIPS European Course in Neurosurgery organised by The European Association of Neurosurgical Societies- four years cycle: Southampton 1997, Madeira 1998, Barcelona 1999 and Nice 2000. Passed the European Association of Neurosurgical Societies European primary examination in June 1999. European Postgraduate Course in Pediatric Neurosurgery organized by European Society of Pediatric Neurosurgeons- three years cycle: Wurzburg, Germany 1997; Lago di Garda, Italy 1998 and Aalborg, Denmark 1999. The 3 rd M Gazi Yaşargil Live Demonstration Course in Operative Microneurosurgery, 19.- 23.05. 2003, Helsinki, Finland. Workshop for Neurosurgeons, Neurosurgical Approaches to Epilepsy. Department of Neurosurgery, Karolinska Institutet/Hospital (J G Villemure), 3.-4.12.2003, Stockholm, Sweden. Microsurgical Approaches to Intrinsic Brain Tumors. Saint Louis University, Practical Anatomy & Surgical Education (M G Yaşargil, U Tϋre). February 25-27, 2005, St. Louis, USA. Fellowship at Cleveland Clinic Foundation 1.7. 31.7.2003: Epilepsy surgery programme at Department of Neurology (Prof. Hans O. Lϋders). Cleveland, USA.