7 November 2014 CURRICULUM VITAE

CURRICULUM VITAE 7 November 2014 KONTTINEN, Yrjö Tapio, Helsinki, 28th September 1952 Institute of Clinical Medicine, Department of Medicine, Biomedicum, PO Box 700 (Haartmaninkatu 8), FI-00029 HUS, FINLAND; e-mail: yrjo.konttinen@helsinki.fi CURRENT POSITION Swedish Professor of Medicine 1.5.2003-, University of Helsinki HU (Professor of Oral Medicine 1999-2003, Inst of Dentistry, HU) Hospital Affiliation Chief Physician of Internal Medicine, Helsinki University Central Hospital HUS 1.1.2000- Research Consultant, ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, 1.8.2000- Co-Editor, Acta Orthopaedica, 2006- Vice-Director, National PhD Graduate School in Musculoskeletal Diseases and Biomaterials, 2007- Head, Musculoskeletal Diseases and Inflammation Research Group, Department of Medicine, HUS, Helsinki, Finland 1980-; and its Cell and Molecular Biology Laboratory, 1991- European Science Foundation Regenerative Medicine RNP with 14 EU member state participants (Director 5/2008-9/2011, Board Member 9/2011-2013) POST-DOC PERIODS International Research Fellow, University of California San Diego, funded by ABROAD NIH Fogarty Center, with Professors Nathan J. Zvaifler and Harry G. Bluestein as hosts, 1982-1984 Institute of Molecular Immunology, Hospital for Joint Diseases, NYU Medical School, New York, NY, with Professor Robert J. Winchester as the host, 1989-1991 Rheumatology/Clinical Immunology, University of Alberta, Edmonton, Alberta, Professors Anthony S. Russell and Paul Davis Laboratoire d'histodynamique Osseuse, Université Claude-Bernard, Faculté de Médecine Alexis Carrel, and Hôpital Edouard Herriot, Lyon, France, Professor Pierre J. Meunier 711 articles in PubMed since 1979 (papers published before 1979 are by my father Yrjö Paul Herman), according to ISI Web of Science cited 19 815 times, Hirsch-index being 61. 189 invited lectures in international meetings Sweden 17, Norway 12, Denmark 16, Iceland 2, Estonia 5, Lithuania 3, Latvia 1, Poland 1, Russia 5, Austria 4, Germany 9, France 7, Belgium 1, Italy 13, Spain 11, Switzerland 3, Hungary 2, Czech Republic 1, Netherlands 3, Portugal 10, Greece 9, Slovenia 2, England & Scotland 12, Ireland 1, Israel 4, USA 12 (New York 5, Florida 2, Texas 2, New Hampshire 1, Pennsylvania 3), Mexico 1, Canada 3, Japan 13, China 2, India 1, Romania 2. This does not include abstract and poster presentations. 45 already supervised PhD thesis works. Opponent 23, expert 27 and kustos 21 times, Member/Chair or other role of Selection Committee of Professors 12 times 70 past or present foreign visiting scientists from 32 different countries have worked in my group Member (past or present) in 13 Editorial Boards of International Peer Review Journals Peer reviews for 151 different journals Grant and other evaluations for international organizations in UK, Ireland, Germany, USA, France, Belgium, Italy, Switzerland, the Netherlands, Portugal, Czech Republic, Estonia, Lithuania, Sweden, Norway, Hong Kong, Singapore and Finland 06.11.2014

LIST OF PUBLICATIONS: Yrjö T. Konttinen Section A Section B Section C Section D Section E Section F Section G Refereed original articles (followed by journal impact index) Reviews and editorials Abstracts Other publications Invited lectures, post-graduate courses, chairmanships etc. (routine weekly staff meeting, teaching as a professor and scientific abstracts are not included except those given when on leave of absence) Television and radio interviews and videos (not included) Patents A. REFEREED ORIGINAL ARTICLES 1. Konttinen YT, Reitamo S: Effect of fixation on the antigenicity of human lactoferrin in paraffin embedded tissues and cytocentrifuged cell smears. Histochemistry 62:55-64, 1979 2. Reitamo S, Ranki A, Konttinen YT, Häyry P: Immunoperoxidase identification of intracellular immunoglobulins from cell smears. Am J Clin Pathol 73:248-249, 1980 3. Reitamo S, Konttinen YT, Segerberg-Konttinen M: Distribution of lactoferrin in human salivary glands. Histochemistry 60:285-291, 1980 4. Ranki A, Reitamo S, Konttinen YT, Häyry P: Histochemical identification of human T lymphocytes from paraffin sections. J Histochem Cytochem 28:704-707, 1980 5. Reitamo S, Konttinen YT, Ranki A, Häyry P: The relation of various subgroups of inflammatory cells to different structural components in rejecting kidney allograft. Histopathology 4:517-532, 1980 6. Bergroth V, Reitamo S, Konttinen YT, Lalla M: Sensitivity and nonspecific staining in various immunoperoxidase techniques. Histochemistry 68:17-22, 1980 7. Konttinen YT, Reitamo S, Ranki A, Segerberg-Konttinen M: T lymphocytes and mononuclear phagocytes in the skin infiltrate of systemic and discoid lupus erythematosus and Jessner's lymphocytic infiltrate. Brit J Dermatol 104:141-145, 1981 8. Reitamo S, Konttinen YT, Dodds S, Adinolfi M: Distribution of lactoferrin in human fetal tissues. Acta Paed Scand 70:395-398, 1981 9. Bergroth V, Reitamo S, Konttinen YT, Wegelius O: Skin lesions in Waldenström's macroglobulinemia: characterization of the cellular infiltrate. Acta Med Scand 209:129-131, 1981 10. Palva T, Reitamo S, Konttinen YT, Häyry P, Rinne J: Inflammatory cell subpopulations in the middle ear mucosa of ears with effusions. Int J Paed ORL 3:71-78, 1981 11. Reitamo S, Reitamo JJ, Konttinen YT, Collan Y, Sipponen P: Lysozyme in neoplastic Paneth cells of a jejunal adenocarcinoma. Acta Path Microbiol Scand Sect A 89:165-168, 1981 12. Konttinen YT, Reitamo S, Ranki A, Häyry P, Kankaanpää U, Wegelius O: Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates. Arthritis Rheum 24:71-79, 1981 13. Konttinen YT: In situ characterization of the cellular infiltrate in labial and palatine glands in Sjögren's syndrome. Scand J Rheumatol 10:321-330, 1981 14. Reitamo S, Reunala T, Konttinen YT, Saksela O, Salo OP: Inflammatory cells, IgA, C3, fibrin and fibronectin in skin lesions in dermatitis herpetiformis. Brit J Dermatol 105:167-177, 1981 15. Reitamo S, Tolvanen E, Konttinen YT, Käyhkö K, Förström L, Salo OP: Allergic and toxic contact dermatitis: Inflammatory cell subtypes of the epicutaneous test reactions. Brit J Dermatol 105:521-527, 1981 16. Palva T, Tolvanen E, Konttinen YT, Reitamo S: Inflammatory cells in the middle ear mucosa in cases of chronic otitis media. Acta Otolaryngol 107:528-531, 1981 17. Bergroth V, Reitamo S, Konttinen YT, Tolvanen E: Fixation-dependent cytoplasmic artefact staining with an immunoperoxidase method. Histochemistry 73:509-513, 1982 18. Konttinen YT, Malmström M, Reitamo S, Tolvanen E, Seppä A, Sirelius K: Oral lesions in lichen planus and systemic lupus erythematosus: a histochemical and immunohistochemical study. Acta Path Microbiol Scand Sect A 90:295-299, 1982

19. Konttinen YT, Bergroth V, Käyhkö K, Reitamo S: Human ferritin: effects of fixation and antigen source on leukocyte staining by immunoperoxidase techniques. Histochemistry 75:585-589, 1982 20. Konttinen YT, Tolvanen E, Johansson E, Reitamo S, Wegelius O: Skin response to intradermal DNA and RNA in systemic lupus erythematosus. Arthritis Rheum 25:1284-1290, 1982 21. Konttinen YT, Friman C, Tolvanen E, Reitamo S, Johansson E: Local skin rash after intra-articular methyl prednisolone acetate injection in a patient with rheumatoid arthritis. Arthritis Rheum 26:231-233, 1983 22. Konttinen YT, Tolvanen E, Visa-Tolvanen K, Reitamo S, Förström L: Inflammatory cells in sarcoid granulomas detected by monoclonal antibodies and esterase technique. Clin Immunol Immunopathol 26:380-389, 1983 23. Bergroth V, Konttinen YT, Reitamo S: A method for the identification of human peripheral blood T lymphocytes by sequential immunogold and esterase double staining. J Histochem Cytochem 31:837-839, 1983 24. Reitamo S, Käyhkö K, Konttinen YT, Bergroth V: Factors affecting the immunoperoxidase demonstration of intracellular immunoglobulins and J chain from cytocentrifuged cell smears. J Histochem Cytochem 31:843-846, 1983 25. Malmström M, Seppä A, Konttinen YT, Helve T, Reitamo S: Sjögren's syndrome in systemic lupus erythematosus and rheumatoid arthritis. Immune effector cells in salivary glands. Rheumatol Int 3:1-5, 1983 26. Konttinen YT, Bergroth V, Visa-Tolvanen K, Reitamo S, Förström L: Cellular infiltrate in situ and response kinetics of human intradermal and epicutaneous tuberculin reactions. Clin Immunol Immunopathol 28:441-449, 1983 27. Kilpi A, Bergroth V, Konttinen YT, Maury P, Reitamo S, Wegelius O: Lymphocytic infiltrations of gastric mucosa in Sjögren's syndrome. An immunoperoxidase study using monoclonal antibodies in the avidin-biotin-peroxidase method. Arthritis Rheum 26:1196-1200, 1983 28. Kilpi A, Konttinen YT, Malmström M, Bergroth V, Reitamo S, Helve T: Immunocompetent cells in labial salivary glands in secondary Sjögren's syndrome associated with SLE. J Oral Pathol 12:465-472, 1983 29. Ranki A, Kanerva L, Förström L, Konttinen YT, Mustakallio KK: T and B lymphocytes, macrophages and Langerhans cells during the course of contact and irritant skin reactions in man. Acta Derm-Venereol (Stockh) 63:376-383, 1983 30. Konttinen YT, Kulomaa M, Malmström M, Kilpi A, Reitamo S: Lactoferrin in Sjögren's syndrome. Arthritis Rheum 27:462-467, 1984 31. Tolvanen E, Konttinen YT, Visa-Tolvanen K, Reunala T, Reitamo S, Kähönen K: Immunocompetent and accessory cells in dermatitis herpetiformis. Clin Immunol Immunopathol 30:134-141, 1984 32. Kähönen K, Palva T, Bergroth V, Konttinen YT, Reitamo S: Immunohistochemical identification of inflammatory cells in secretary and chronic otitis media and cholesteatoma using monoclonal antibodies. Acta Otolaryngol 97:431-436, 1984 33. Konttinen YT, Bluestein HG, Zvaifler NJ: Regulation of the growth of Epstein-Barr virus infected B cells. I. Growth regression by E-rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8 memory cells. J Immunol 134:2287-2293, 1985 34. Bergroth V, Konttinen YT, Nykänen P, von Essen R, Koota K: Proliferating cells in the synovial fluid in rheumatic diseases: an analysis with autoradiography-immunoperoxidase double staining. Scand J Immunol 22:383-388, 1985 35. Konttinen YT, Bergroth V, Nykänen P: Lymphocyte activation in rheumatoid arthritis synovial fluid in vivo. Scand J Immunol 22:503-507, 1985 36. Konttinen YT, Bergroth V, Nordström D, Koota K, Skrifvars B, Hagman G, Friman C, Hämäläinen M, Slätis P: Cellular immunohistopathology of acute, subacute and chronic synovitis in rheumatoid arthritis. Ann Rheum Dis 44:549-555, 1985 37. Bergroth V, Konttinen YT, Johansson E: Langerhans cells in SLE skin: a role in lymphocyte migration and activation in situ. Scand J Rheumatol 14:411-416, 1985 38. Nordström D, Konttinen YT, Bergroth V, Leirisalo-Repo M: Synovial fluid cells in Reiter's Syndrome. Ann Rheum Dis 44:852-856, 1985

39. Konttinen YT, Bergroth V, Kunnamo I, Haapasaari J: The value of biopsy in patients with monoarticular juvenile rheumatoid arthritis of recent onset. Arthritis Rheum 29:47-53, 1986 40. Konttinen YT, Bluestein HG, Zvaifler NJ: Regulation of the growth of Epstein-Barr virus infected B cells: Temporal profile of the in vitro development of three distinct cytotoxic cells. Cellular Immunol 103:84-95, 1986 41. Bergroth V, Konttinen YT, Segerberg-Konttinen M, Ollikainen V, Salaspuro M: Phenotypic in situ characterization of lymphocytes in mild alcoholic liver diseases. Acta Pathol Microbiol Scand Sect A 94:337-341, 1986 42. Konttinen YT, Nordström D, Bergroth V, Leirisalo-Repo M, Skrifvars B: Cell-mediated immune response in the diseased joints in patients with reactive arthritis. Scand J Immunol 23:685-691, 1986 43. Konttinen YT, Bergroth V, Nordström D, Segerberg-Konttinen M, Tolvanen E: Expression of MHC class II antigen, interleukin-2 receptor, transferrin receptor and gp 40/80 glycoprotein during different phases of a normal PHA driven lymphocyte activation in vitro. Acta Pathol Microbiol Scand Sect C 94:181-186, 1986 44. Lindqvist C, Santavirta S, Sandelin J, Konttinen YT: Dysphagia and micrognathia in a patient with juvenile rheumatoid arthritis. Clin Rheumatol 5:410-415, 1986 45. Nykänen P, Bergroth V, Raunio P, Nordström D, Konttinen YT: Phenotypic characterization of 3 H-thymidine incorporating cells in rheumatoid arthritis synovial membrane. Rheumatol Int 6:269-271, 1986 46. Konttinen YT, Bergroth V, Nordström D, Segerberg-Konttinen M, Seppälä K, Salaspuro M: Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn`s disease. J Clin Lab Immunol 22:59-63, 1987 47. Santavirta S, Slätis P, Sandelin J, Lindqvist C, Konttinen YT: Atlanto-axial subluxation in patients with seronegative spondylarthritis. Rheumatol Int 7:43-46, 1987 48. Bergroth V, Konttinen YT, Nordström D, Pettersson T, Tolvanen E: Lymphocyte subpopulations, activation phenotypes and spontaneous proliferation in tuberculous pleural effusions. Chest 91:338-341, 1987 49. Konttinen YT, Kinnunen E, von Bonsdorff M, Lillqvist P, Immonen I, Bergroth V, Segerberg- Konttinen M, Friman C: Acute transverse myelopathy successfully treated with plasmapheresis and prednisone in a patient with primary Sjögren's syndrome. Arthritis Rheum 30:339-344, 1987 50. Konttinen YT, Bergroth V, Santavirta S, Sandelin J: Inflammatory involvement of cervical spine ligaments in rheumatoid arthritis patients with atlanto-axial subluxation. J Rheumatol 14:531-534, 1987 51. Nordström D, Konttinen YT, Bergroth V, Segerberg-Konttinen M, Santavirta S: T cell subsets in the blast cell population in phytohemagglutinin-stimulated peripheral blood in vitro and in rheumatoid arthritis synovial fluid in vivo. Rheumatol Int 7:67-70, 1987 52. Segerberg-Konttinen M, Bergroth V, Jungell P, Malmström M, Sane J, Immonen I, Nordström D, Konttinen YT: T lymphocyte activation state in the minor salivary glands of patients with Sjögren's syndrome. Ann Rheum Dis 46:649-653, 1987 53. Konttinen YT, Bergroth V, Johansson E, Nordström D, Malmström M: A long-term clinicopathological survey of patients with Jessner's lymphocytic infiltration of the skin. J Invest Dermatol 89:205-208, 1987 54. Konttinen YT, Bergroth V, Kinnunen E, Nordström D, Kouri T: Activated T lymphocytes in patients with multiple sclerosis in clinical remission. J Neurol Sci 81:133-139, 1987 55. Santavirta S, Lamberg M, Kiviluoto O, Konttinen YT, Möller C: Zervikale Spondylitis als Folge der Gummi-ligaturbehandlung von Hämorrhoiden. Zentralbl Chir 112:725-728, 1987 56. Konttinen YT, Bergroth V, Nordström D, Tallgren LG, von Bonsdorff M, Santavirta S: IgA nephropathy in reactive arthritis. J Rheumatol 14:1070-1071, 1987 57. Jungell P, Malmström M, Wartiovaara J, Konttinen YT, Sane J: Ultrastructure of oral leukoplakia and lichen planus. I. Basal region and inflammatory cells. J Oral Pathol 16:170-178, 1987 58. Jungell P, Malmström M, Wartiovaara J, Konttinen YT: Ultrastructure of oral leukoplakia and lichen planus. II. A correlated scanning- and transmission electron microscopic study of epithelial surface cells. J Oral Pathol 16:287-293, 1987 59. Bergroth V, Konttinen YT, Nordström D, Laasonen L: The loin pain/haematuria syndromepossible association with intrarenal arterial spasms. Br Med J 294:1657, 1987

60. Santavirta S, Hopfner-Hallikainen D, Paukku P, Sandelin J, Konttinen YT: Atlanto-axial facet joint arthritis in the rheumatoid cervical spine. A panoramic zonography study. J Rheumatol 15:217-223, 1988 61. Malmström M, Konttinen YT, Jungell P, Bergroth V, Segerberg-Konttinen M, Nordström D: Lymphocyte activation in oral lichen planus in situ. Am J Clin Pathol 89:329-334, 1988 62. Bergroth V, Konttinen YT, Piirainen H, Johansson E, Nordström D, Malmström M: Evaluation of lymphocyte activation in skin lesions of patients with mixed connective tissue disease and discoid lupus erythematodes. Arch Dermatol Res 280:1-4, 1988 63. Malmström MJ, Segerberg-Konttinen M, Tuominen TS, Hietanen JH, Wolf JE, Sane JI, Konttinen YT: Xerostomia due to Sjögren's syndrome. Diagnostic criteria, treatment and outlines for a continuous dental care program and an open trial with Sulfarlem R. Scand J Rheumatol 17:77-86, 1988 64. Bergroth V, Konttinen YT, Pelkonen P, Haapala M, Haapasaari J, Nordström D, Kunnamo I, Friman C: Synovial fluid lymphocytes in various subtypes of juvenile rheumatoid arthritis. Arthritis Rheum 31:780-783, 1988 65. Santavirta S, Bardy B, Tukiainen E, Konttinen YT, Ahovuo J, Björkenheim J-M: Why does high tibial osteotomy occasionally fail? J Orthop Rheumatol 1:41-50, 1988 66. Eskola A, Santavirta S, Konttinen YT, Tallroth K, Hoikka V, Lindholm ST: Cementless total replacement for old tuberculosis of the hip. J Bone Joint Surg (Br) 70-B:603-606, 1988 67. Santavirta S, Eskola A, Konttinen YT, Tallroth K, Lindholm ST: Total hip replacement in old tuberculosis. A report of 14 cases. Acta Orthop Scand 59:391-395, 1988 68. Konttinen YT, Segerberg-Konttinen M, Nordström D, Bergroth V, Scheinin T, Saari H: An immunoperoxidase-autoradiography double labeling method for analysis of lymphocyte activation markers and DNA synthesis. J Immunol Methods 110:19-27, 1988 69. Eskola A, Santavirta S, Konttinen YT, Tallroth K, Lindholm ST: Arthroplasty for old tuberculosis of the knee. J Bone Joint Surg (Br) 70-B:767-769, 1988 70. Santavirta S, Wennerstrand M, Konttinen YT, Ahovuo J, Saari H: Long-term follow-up of Geomedic knee arthroplasties. J Orthop Rheumatol 1:185-188, 1988 71. Konttinen YT, Nordström D, Bergroth V, Leirisalo-Repo M, Santavirta S: Occurrence of different ensuing triggering infections preceding reactive arthritis: a follow-up study. Br Med J 296:1644-1645, 1988 72. Mussalo-Rauhamaa H, Konttinen YT, Lehto J, Honkanen V: Predictive clinical and laboratory parameters for serum zinc and copper in rheumatoid arthritis. Ann Rheum Dis 47:816-819, 1988 73. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvuo M, Kaprio J: Genetic susceptibility to multiple sclerosis. A co-twin study of a nationwide series. Arch Neurol 45:1108-1111, 1988 74. Grönblad M, Konttinen YT, Korkala O, Liesi P, Hukkanen M, Polak JM: Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 15:1807-1810, 1988 75. Stephansson EA, Konttinen YT, Raunio V, Salo OP: DNA skin tests in patients with definite or suspected systemic lupus erythematosus and in dermatological control patients. A long-term follow-up study. Scand J Rheumatol 18:419-426, 1989 76. Sorsa T, Konttinen YT, Lauhio A, Saari H, Suomalainen K, Lindy S: Gold (I) compounds and human neutrophil collagenase. J Rheumatol 16:1009-1010, 1989 77. Saari H, Konttinen YT, Santavirta S: Synovial fluid hyaluronate: a study using high performance liquid chromatography with size exclusion column. Med Sci Res 17:99-101, 1989 78. Konttinen YT, Hoikka V, Landtman M, Saari H, Santavirta S, Metsärinne K, Seegmiller JE: Alkaptonuria/ochronosis: a report of a case and a review of literature. Clin Exp Rheumatol 7:435-444, 1989 79. Konttinen YT, Santavirta S, Kauppi M, Isomäki H, Slätis P, Hämäläinen M, Sakaguchi M: Atlantoaxial laxity in rheumatoid arthritis. Acta Orthop Scand 60:379-382, 1989 80. Santavirta S, Konttinen YT, Nordström D, Bergroth V, Antti-Poika I, Eskola A: Immuneinflammatory response in infected arthroplasties. Acta Orthop Scand 60:116-118, 1989 81. Kinnunen E, Konttinen YT, Bergroth V, Kemppinen P: Immunological studies on patients with opticus neuritis without evidence of multiple sclerosis. Arch Neurol 90:43-52, 1989

82. Konttinen YT, Segerberg-Konttinen M, Guseva N, Keinonen M, Kirtava ZZ, Kaarela K, Molander G, Lehtinen K, Sorsa S: Subjective disease experience in Sjögren's syndrome. A computerized discrimination analysis. Scand J Rheumatol 18:13-20, 1989 83. Konttinen YT, Jungell P, Bergroth V, Hampf G, Kemppinen P, Malmström M: PHA stimulation of peripheral blood lymphocytes in oral lichen planus. Abnormality localized between interleukin-2 receptor ligand formation and gamma-interferon secretion. J Clin Lab Immunol 28:33-37, 1989 84. Slätis P, Santavirta S, Sandelin J, Konttinen YT: Cranial subluxation of the odontoid process in rheumatoid arthritis. J Bone Joint Surg (Am) 71:189-195, 1989 85. Konttinen YT, Nykänen P, Nordström D, Saari H, Sandelin J, Santavirta S, Kouri T: DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study. J Rheumatol 16:339-345, 1989 86. Saari H, Konttinen YT: Determination of synovial fluid hyaluronate concentration and polymerization by high performance liquid chromatography. Ann Rheum Dis 48:565-570, 1989 87. Sorsa T, Suomalainen K, Konttinen YT, Saari HT, Lindy S: Identification of protease(s) capable of further degrading native 3/4- and 1/4 -collagen fragments generated by collagenase from native type I collagen in human neutrophils. Proc Finn Dental Soc 85:3-11, 1989 88. Saari H, Konttinen YT, Tulamo R-M, Antti-Poika I, Honkanen V: Concentration and degree of polymerization of hyaluronate in equine synovial fluid. Am J Vet Res 50:2060-2063, 1989 89. Antti-Poika I, Santavirta S, Konttinen YT, Honkanen V: Outcome of the infected hip arthroplasty. A retrospective study of 36 patients. Acta Orthop Scand 60:670-675, 1989 90. Honkanen V, Konttinen YT, Mussalo-Rauhamaa H: Vitamin A, E, retinol binding protein and zinc in rheumatoid arthritis. Clin Exp Rheumatol 7:465-469, 1989 91. Konttinen YT, Bergroth V, Kulomaa M, Nordström D, Segerberg-Konttinen M, Keinänen R, Kemppinen P, Hukkanen M, Grönblad M: Localization of lysozyme mrna in rheumatoid synovial membrane by in situ hybridization. Ann Rheum Dis 48:912-917, 1989 92. Tallroth K, Eskola A, Santavirta S, Konttinen YT, Lindholm TS: Aggressive granulomatous lesions after hip arthroplasty. J Bone Joint Surg (Br) 71-B: 571-575, 1989 93. Jungell P, Konttinen YT, Nortamo P, Malmström M: Immunoelectron microscopic study of distribution of T cell subsets in oral lichen planus. Scand J Dent Res 97:361-367, 1989 94. Konttinen YT, Grönblad M, Bergroth V, Santavirta S, Antti-Poika I: Presence of platelet glycoprotein Ib and IIb-IIIa in inflammatory and non-inflammatory synovium. J Rheumatol 16:578-584, 1989 95. Mashkilleyson N, Konttinen YT, Visa K: Local involvement of antigen-presenting cells and activated T cells in perilesional and clinically uninvolved skin in pemphigus vulgaris. Acta Derm- Venereol (Stockh) 69:424-428, 1989 96. Sorsa T, Saari H, Konttinen YT, Uitto V-J, Lindy S: Human neutrophil collagenase and oxygen derived free radicals. N Engl J Med 321:327-328, 1989 97. Santavirta S, Antti-Poika I, Konttinen YT: Risk of fatal outcome in infected hip arthroplasty. J Orthop Rheumatol 2:231-233, 1989 98. Suominen S, Antti-Poika I, Santavirta S, Konttinen YT: Infection of total hip arthroplasty. Treatment with resection arthroplasty and late hip rearthroplasty. Hokkaido J Orthop 33:55-60, 1989 99. Santavirta S, Konttinen YT, Sandelin J, Slätis P: Operations for the unstable cervical spine in rheumatoid arthritis. Sixteen cases of subaxial subluxation. Acta Orthop Scand 61:106-110, 1990 100. Malmström M, Ruokonen H, Konttinen YT, Bergroth V, Segerberg-Konttinen M, Hietanen J, Nordström D, Haapala M: Herpes simplex virus antigens and inflammatory cells in recurrent oral lesions in recurrent erythema multiforme. Immunoperoxidase, autoradiographical and electron microscopical studies. Acta Derm-Venereol (Stockh) 70:405-410, 1990 101. Nykänen PJ, Konttinen YT, Bergroth V: Chemoattractant production by synovial fluid cells in chronic arthritis. A study with a new double-chamber method for quantitating the motility of mononuclear cells labelled with chromium-51. Clin Rheumatol 9:389-396, 1990 102. Konttinen YT, Kulomaa M, Segerberg-Konttinen M, Nordström D, Keinänen R, Grönblad M, Malmström M: Localization of lysozyme mrna in the labial salivary glands by in situ hybridization in Sjögren's syndrome. Scand J Dent Res 98:318-325, 1990

103. Kinnunen E, Juntunen J, Konttinen YT, Kemppinen P, Koskimies S, Ketonen L, Kleemola P, Koskenvuo M: Multiple sclerosis and systemic lupus erythematosus in twins of successive generations. Acta Neurol Scand 81:246-249, 1990 104. Konttinen YT, Santavirta S, Grönblad M, Kauppi M, Sakaguchi M, Hämäläinen M, Michelsson J- E, Polak JM, Dahl D: A retrospective clinical and neuroimmunohistochemical study of rheumatoid arthritis patients with atlanto-axial subluxation. Scand J Rheumatol 19:43-49, 1990 105. Konttinen YT, Pettersson T, Kemppinen P, Friman C: Spontaneous and in vitro activation of synovial fluid and peripheral blood lymphocytes in rheumatoid arthritis. Clin Rheumatol 9:325-332, 1990 106. Konttinen YT, Tuominen S, Piirainen H, Könönen M, Wolf J, Hietanen J, Malmström M: Signs and symptoms in the masticatory system in ten patients with mixed connective tissue disease. Scand J Rheumatol 19:363-373, 1990 107. Konttinen YT, Grönblad M, Antti-Poika I, Seitsalo S, Santavirta S, Hukkanen M, Polak JM: Neuroimmunohistological analysis of peridiscal nociceptive neural elements. Spine 15:383-386, 1990 108. Konttinen YT, Kinnunen E, Kemppinen P, Juntunen J, Koskenvuo M: Lymphocyte activation in discordant multiple sclerosis twin pairs. J Neuroimmunol 27:1-8, 1990 109. Konttinen YT, von Essen R, Grönblad M, Vahvanen V, Santavirta S, Antti-Poika I, Hämäläinen M: Fibroblasts in synovitis in rheumatoid arthritis but not in non-inflammatory synovial tissue in meniscus lesions express the carboxyterminal domain of procollagen type I. Am J Clin Pathol 93:340-346, 1990 110. Konttinen YT, Michelsson J-E, Tolvanen E, Bergroth V: Primary inflammatory reaction in synovial fluid and tissue in rabbit immobilization osteoarthritis. Clin Orthop Res 260:280-286, 1990 111. Kinnunen E, Kauppi M, Ketonen L, Sepponen R, Tanttu J, Konttinen YT, Isomäki H: Low-field MRI in the evaluation of rheumatoid cervical spine. Comparison with neurological findings and routine plain radiography. Clin Exp Rheumatol 8:365-373, 1990 112. Wirta J, Eskola A, Santavirta S, Tallroth K, Konttinen YT, Lindholm S: Revision of aggressive granulomatous lesions in hip arthroplasty. J Arthroplasty 5 Suppl:S47-52, 1990 113. Kauppi M, Sakaguchi M, Konttinen YT, Hämäläinen M: A new method of screening for vertical atlanto-axial dislocation. J Rheumatol 17:167-172, 1990 114. Konttinen YT, Grönblad M, Korkala O, Tolvanen E, Polak JM: Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints. Spine 15:387-390, 1990 115. Antti-Poika I, Soini J, Tallroth K, Yrjönen T, Konttinen YT: Clinical relevance of discography combined with CT scanning. A study of 100 patients. J Bone Joint Surg (Br) 72-B:480-485, 1990 116. Tulamo R-M, Saari H, Konttinen YT: Determination of concentration of hyaluronate in equine serum. Am J Vet Res 51:740-742, 1990 117. Janin A, Konttinen YT, Grönblad M, Karhunen P, Gosset D, Malmström M: Fibroblast markers in labial salivary gland biopsies in progressive systemic sclerosis. Clin Exp Rheumatol 8:237-242, 1990 118. Eskola A, Santavirta S, Konttinen YT, Hoikka V, Tallroth K, Lindholm TS: Cementless revision of aggressive granulomatous lesions in hip replacements. J Bone Joint Surg (Br) 72-B:212-216, 1990 119. Santavirta S, Konttinen YT, Bergroth V, Eskola A, Tallroth K, Lindholm TS: Aggressive granulomatous lesions associated with hip arthroplasty. Immunopathological studies. J Bone Joint Surg (Am) 72-A:252-258, 1990 120. Konttinen YT, Tuominen S, Segerberg-Konttinen M, Jungell P, Malmström MJ, Grönblad M, Güven O, Santavirta S, Panula P: Mast cells in the labial salivary glands of patients with Sjögren's syndrome: a histological, immunohistochemical, and electron microscopical study. Ann Rheum Dis 49:685-689, 1990 121. Santavirta S, Konttinen YT, Saito T, Grönblad M, Partio E, Kemppinen P, Rokkanen P: Immune response to polyglycolic acid implants. J Bone Joint Surg (Br) 72-B:597-600, 1990 122. Grönblad M, Lukinmaa A, Konttinen YT: Chronic low-back pain: Intercorrelation of repeated measures for pain and disability. Scand J Rehab Med 22:73-77, 1990

123. Konttinen YT, Rees R, Hukkanen M, Grönblad M, Tolvanen E, Gibson SJ, Polak JM, Brewerton DA: Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritic rat model. J Rheumatol 17:1586-1591, 1990 124. Santavirta S, Hoikka V, Eskola A, Konttinen YT, Paavilainen T, Tallroth K: Aggressive granulomatous lesions in cementless total hip arthroplasty. J Bone Joint Surg (Br) 72-B:980-984, 1990 125. Santavirta S, Konttinen YT, Sandelin J, Grönblad M, Antti-Poika I: Cervical spine subluxation in ankylosing spondylitis treated surgically. J Orthop Rheumatol 3:57-60, 1990 126. Sorsa T, Helenius J, Suomalainen K, Lindy S, Saari H, Konttinen YT, Uitto V-J: Chlorhexidine and autoactivation of collagenase by human neutrophils. N Engl J Med 323:133-134, 1990 127. Honkanen VEA, Pelkonen P, Konttinen YT, Mussalo-Rauhamaa H, Lehto J, Westermarck T: Serum cholesterol and vitamins A and E in juvenile chronic arthritis. Clin Exp Rheumatol 8:187-191, 1990 128. Saari H, Suomalainen K, Lindy O, Konttinen YT, Sorsa T: Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases. Biochem Biophys Res Commun 171:979-987, 1990 129. Konttinen YT, Saari H, Honkanen V, Szocsik K, Mussalo-Rauhamaa H, Friman C: Serum baseline hyaluronate and disease activity in rheumatoid arthritis. Clin Chim Acta 193:39-47, 1991 130. Tallroth K, Antti-Poika I, Konttinen YT, Soini J, Honkanen V, Yrjönen T: Premedication and short term complications in iohexol discography. Ann Chir Gynaecol 80:49-53, 1991 131. Saari H, Konttinen YT, Nordström D: The effect of joint mobilization on serum hyaluronate. Ann Med 23:29-32, 1991 132. Konttinen YT, Saari H, Nordström D: Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells. Clin Rheumatol 10:151-154, 1991 133. Soini J, Antti-Poika I, Tallroth K, Konttinen YT, Honkanen V, Santavirta S: Disc degeneration and angular movement of the lumbar spine. A comparative study using plain and flexion-extension radiography and discography. J Spinal Disorders 4:183-187, 1991 134. Konttinen YT, Lindy O, Kemppinen P, Saari H, Suomalainen K, Vauhkonen M, Lindy S, Sorsa T: Collagenase reserves in polymorphonuclear neutrophil leukocytes from synovial fluid and peripheral blood of patients with rheumatoid arthritis. Matrix 11:296-301, 1991 135. Hukkanen M, Grönblad M, Rees R, Konttinen YT, Gibson S, Hietanen J, Polak JM, Brewerton D: Regional distribution of mast cells and peptide-containing nerves in normal and adjuvant arthritic rat synovium. J Rheumatol 18:177-183, 1991 136. Grönblad M, Korkala O, Konttinen YT, Nederström A, Hukkanen M, Tolvanen E, Polak JM: Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue. Spine 16:34-38, 1991 137. Konttinen YT, Michelsson J-E, Grönblad M, Jaakkola L, Honkanen V: Plasma hyaluronate levels in rabbit immobilization osteoarthritis: effect of remobilization. Scand J Rheumatol 20:392-396, 1991 138. Grönblad M, Korkala O, Konttinen YT, Kuokkanen H, Liesi P: Immunoreactive neuropeptides in nerves in ligamentous tissue. An experimental neuroimmunohistochemical study. Clin Orthop Res 265:291-296, 1991 139. Kauppi M, Konttinen YT, Honkanen V, Sakaguchi M, Hämäläinen M, Santavirta S: A multivariate analysis of risk factors for anterior atlantoaxial subluxation and evaluation of the effect of glucocorticoid treatment on the upper rheumatoid cervical spine. Clin Rheumatol 10:413-418, 1991 140. Konttinen YT, Santavirta N, Honkanen V, Sandelin S, Schauman L, Grönblad M: Systemic lupus erythematosus patient guide: influence on knowledge of the disease. Ann Rheum Dis 50:900-902, 1991 141. Santavirta S, Konttinen YT, Bergroth V, Grönblad M: Lack of immune response to methyl methacrylate in lymphocyte cultures. Acta Orthop Scand 62:29-32, 1991 142. Santavirta S, Konttinen YT, Laasonen E, Honkanen V, Antti-Poika I, Kauppi M: Ten-year results of operations for rheumatoid cervical spine disorders. J Bone Joint Surg (Br) 73-B:116-120, 1991 143. Santavirta S, Konttinen YT, Hoikka V, Eskola A: Immunopathological response to loose cementless acetabular components. J Bone Joint Surg (Br) 73-B:38-42, 1991

144. Suomalainen K, Sorsa T, Lindy O, Saari H, Konttinen YT, Uitto V-J: Hypochlorous acid induced activation of human neutrophil and gingival crevicular fluid collagenase can be inhibited by ascorbate. Scand J Dent Res 99:397-405, 1991 145. Santavirta S, Nordström D, Ylinen P, Konttinen YT, Silvennoinen T, Rokkanen P: Biocompatibility of hydroxyapatite-coated hip prostheses. Arch Orthop Trauma Surg 110:288-292, 1991 146. Konttinen YT, Lindy O, Suomalainen K, Ritchlin C, Saari H, Vauhkonen M, Lauhio A, Santavirta S, Sorsa T: Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium. Matrix Biol 11:395-403, 1991 147. Honkanen V, Konttinen YT, Sorsa T, Hukkanen M, Kemppinen P, Santavirta S, Saari H, Westermarck T: Serum zinc, copper and selenium in rheumatoid arthritis. J Trace Elem Electrol Health Dis 5:261-263, 1991 148. Honkanen VEA, Lamberg-Allardt C, Vesterinen MK, Lehto JH, Westermarck TW, Metsä-Ketelä TK, Mussalo-Rauhamaa MH, Konttinen YT: Plasma zinc and copper concentrations in rheumatoid arthritis: influence of dietary factors and disease activity. Am J Clin Nutr 54:1082-1086, 1991 149. Suominen S, Antti-Poika I, Santavirta S, Konttinen YT, Honkanen V, Lindholm TS: Total hip replacement after intertrochanteric osteotomy. Orthopedics 3:253-257, 1991 150. Häyrinen-Immonen R, Nordström D, Malmström M, Hietanen J, Konttinen YT: Immuneinflammatory cells in recurrent oral ulcers (ROU). Scand J Dent Res 99:510-518, 1991 151. Santavirta S, Pajamäki J, Eskola A, Konttinen YT, Lindholm TS: Proliferative cell response to the loosening of THR. A cytofluorographic cell cycle analysis. Arch Orthop Trauma Surg 111:43-46, 1991 152. Konttinen YT, Honkanen VEA, Grönblad MÅ, Keinonen M, Santavirta N, Santavirta S: The relation of extra-articular tenderness to inflammatory joint disease and personality in patients with rheumatoid arthritis. J Rheumatol 19:851-855, 1992 153. Saari H, Tulamo R-M, Konttinen YT, Sorsa T: Methylprednisolone acetate -induced release of cartilage proteoglycans: determination by high-performance liquid chromatography (HPLC). Ann Rheum Dis 51:214-219, 1992 154. Konttinen YT, Hukkanen M, Segerberg M, Rees R, Kemppinen P, Sorsa T, Saari H, Polak JM, Santavirta S: Relationship between neuropeptide immunoreactive nerves and inflammatory cells in adjuvant arthritic rats. Scand J Rheumatol 21:55-59, 1992 155. Hukkanen M, Konttinen YT, Rees RG, Gibson SJ, Santavirta S, Polak JM: Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene related peptide containing sensory fibers. J Rheumatol 19:1252-1259, 1992 156. Santavirta S, Nordström D, Saari H, Paavolainen P, Konttinen YT: Immune-inflammatory response in the loosening of the totally replaced hip. J Orthop Rheumatol 5:71-77, 1992 157. Konttinen YT, Kemppinen P, Segerberg-Konttinen M, Sorsa T, Saari H, Hukkanen M: Reactive oxygen species induced structural alterations of substance P. Mediators Inflam 1:355-360, 1992 158. Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee H-M, Uitto V-J, Saari H, Konttinen YT: Specificity of the anti-collagenase action of tetracyclines: relevance to their anti-inflammatory potential. Antimicrobial Agents Chemother 36:227-229, 1992 159. Konttinen YT, Hukkanen M, Kemppinen P, Segerberg M, Sorsa T, Malmström M, Rose S, Itescu S, Polak JM: Peptide-containing nerves in labial salivary glands in Sjögren's syndrome. Arthritis Rheum 35:815-820, 1992 160. Santavirta S, Konttinen YT, Heliövaara M, Knekt P, Lüthje P, Aromaa A: Determinants of osteoporotic thoracic vertebral fracture. Acta Orthop Scand 63:198-202, 1992 161. Konttinen YT, Sorsa T, Hukkanen M, Segerberg M, Kuhlefelt-Sundström M, Malmström M, Polak JM: Topology of innervation of labial salivary glands by protein gene product 9.5- and synaptophysin-immunoreactive nerves in patients with Sjögren's syndrome. J Rheumatol 19:30-37, 1992 162. Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT: The anticollagenolytic potential of lymecycline in long-term treatment of reactive arthritis. Arthritis Rheum 35:195-198, 1992 163. Santavirta S, Konttinen YT, Antti-Poika I, Nordström D: Inflammation of the subacromial bursa in chronic shoulder pain. Arch Orthop Trauma Surg 111:336-340, 1992

164. Sorsa T, Ingman T, Suomalainen K, Halinen S, Saari H, Konttinen YT, Uitto V-J, Golub LM: Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus. J Clin Periodontol 19:146-149, 1992 165. Metsärinne K, Nordström D, Teppo AM, Konttinen YT, Fyhrquist F: Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis and systemic lupus erythematosus. Rheumatol Int 12:93-96, 1992 166. Hukkanen M, Konttinen YT, Rees RG, Santavirta S, Terenghi G, Polak JM: Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone. Int J Tissue Reactions 14:1-10, 1992 167. Saari H, Sorsa T, Lindy O, Suomalainen K, Halinen S, Konttinen YT: Reactive oxygen species and hyaluronate in serum and synovial fluid in arthritis. Int J Tissue Reactions 14:113-120, 1992 168. Hukkanen M, Konttinen YT, Terenghi G, Polak JM: Peptide-containing innervation of rat femoral lymphatic vessels. Microvascular Res 43:7-19, 1992 169. Häyrinen-Immonen R, Malmström M, Nordström D, Sorsa T, Konttinen YT: Distribution of adhesion receptors in recurrent oral ulcers. J Oral Pathol Med 21:199-202, 1992 170. Nordström D, Konttinen YT, Sorsa T, Nykänen P, Pettersson T, Santavirta S, Tschopp J: Granzyme A -immunoreactive cells in synovial fluid in rheumatoid and reactive arthritis. Clin Rheumatol 11:529-532, 1992 171. Santavirta S, Konttinen YT, Nordström D, Mäkelä A, Sorsa T, Hukkanen M, Rokkanen P: Immunologic studies of nonunited fractures. Acta Orthop Scand 63:579-586, 1992 172. Konttinen YT, Santavirta S, Paavolainen P, Antti-Poika I, Tiainen T, Nordström D, Hukkanen M: Immunoreactive neuropeptide nerves in ligamentous tissue in chronic shoulder pain. Arch Orthop Trauma Surg 111:341-344, 1992 173. Suomalainen K, Halinen S, Ingman T, Lindy O, Saari H, Konttinen YT, Golub LM, Sorsa T: Tetracyclin inhibition identifies the cellular sources of interstitial collagenase in gingival crevicular fluid in different forms of periodontal diseases. Drugs Exp Clin Res 18:99-104, 1992 174. Gray C, Hukkanen M, Konttinen YT, Terenghi G, Arnett TR, Jones SJ, Burnstock G, Polak JM: Rapid neural growth: calcitonin gene-related peptide and substance P-containing nerves attain exceptional growth rates in regenerating deer antler. Neuroscience 50:953-963, 1992 175. Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, Saari H, Uitto V-J: Identification of proteases from potent periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun 60:4491-4495, 1992 176. Saari H, Konttinen YT, Friman C, Sorsa T: Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17:403-415, 1993 177. Santavirta S, Sorsa T, Konttinen YT, Saari H, Eskola A, Eisen AZ: Role of mesenchymal collagenase in the loosening of total hip prosthesis. Clin Orthop Res 290:206-215, 1993 178. Saari H, Törnwall J, Halinen S, Tulamo R-M, Sorsa T, Lauhio A, Konttinen YT: The simultaneous determination of hyaluronate and proteoglycan subunits from synovial fluid by high performance liquid chromatography. Progr Rheumatol 5:10-14, 1993 179. Saari H, Santavirta S, Nordström D, Paavolainen P, Konttinen YT: Hyaluronate in total hip replacement. J Rheumatol 20:87-90, 1993 180. Santavirta S, Grönblad M, Antti-Poika I, Konttinen YT, Polak JM: Protein gene product 9.5- (PGP 9.5-), synaptophysin- and neuropeptide-immunoreactive nerves in human subacromial bursal tissue. Eur J Exp Musculoskel Res 2:93-99, 1993 181. Ruokonen H, Hietanen J, Malmström M, Sane J, Häyrinen-Immonen R, Hukkanen M, Konttinen YT: Peripheral nerves and mast cells in normal buccal mucosa. J Oral Pathol Med 22:30-34, 1993 182. Häyrinen-Immonen R, Sorsa T, Nordström D, Malmström M, Konttinen YT: Collagenase and stromelysin in recurrent aphthous ulcers (RAU). Int J Oral Maxillofac Surg 22:46-49, 1993 183. Santavirta S, Nordström D, Tallroth K, Eskola A, Hoikka V, Paavilainen T, Konttinen YT: Granulomatous reaction in cementless total hip replacement. Orthopedics Int 1:228-231, 1993 184. Hukkanen M, Konttinen YT, Santavirta S, Paavolainen P, Gu XH, Terenghi G, Polak JM: Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience 54:969-979, 1993

185. Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee H-M, Golub LM, Hall J, Simon S: Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrobial Agents Chemother 37:592-594, 1993 186. Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K: Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis. Oral Microbiol Immunol 8:298-305, 1993 187. Santavirta S, Turunen V, Ylinen P, Konttinen YT, Tallroth K: Foot and ankle fusions in Charcot- Marie-Tooth disease. Arch Orthop Traum Surg 112:175-179, 1993 188. Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, Braga S, Coll J, De Vita S, Drosos AA, Ehrenfeld M, Hatron PY, Hay EM, Isenberg DA, Janin A, Kalden JR, Kater L, Konttinen YT, Maddison PJ, Maini RN, Manthorpe R, Meyer O, Ostuni P, Pennec Y, Prause JU, Richards A, Sauvezie B, Schiødt M, Sciuto M, Scully C, Shoenfeld Y, Skopouli FN, Smolen JS, Snaith ML, Tishler M, Todesco S, Valesini G, Venables PJ W, Wattiaux MJ, Youinou P. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 36:340-347, 1993 189. Aro T, Kanerva L, Häyrinen-Immonen R, Konttinen YT, Silvennoinen-Kassinen S, Jolanki R, Estlander T: Long-lasting allergic patch test reaction caused by gold. Contact Dermatitis 28:276-281, 1993 190. Santavirta S, Nordström D, Metsärinne K, Konttinen YT: Biocompatibility of polyethylene and host response to loosening of cementless total hip replacement. Clin Orthop Rel Res 297:100-110, 1993 191. Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT: The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases. Arthritis Rheum 36:1335-1336, 1993 192. Grönblad M, Nykänen J, Konttinen Y, Järvinen E, Helve T: Effect of zopiclone on sleep quality, morning stiffness, widespread tenderness and pain and general discomfort in primary fibromyalgia patients. A double-blind randomized trial. Clin Rheumatol 12:186-191, 1993 193. Lauhio A, Konttinen YT, Salo T, Tschesche H, Lähdevirta J, Woessner F Jr, Golub LM, Sorsa T: Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis. Ann NY Acad Sci 732:424-426, 1994 194. Salo T, Sorsa T, Lauhio A, Konttinen YT, Ainamo A, Kjeldsen L, Borregaard N, Ranta H, Lähdevirta J: Matrix metalloproteinases, their endogenous inhibitors and microbial activators in gingival crevicular fluid and saliva of HIV (+)-subjects. Ann NY Acad Sci 732:476-478, 1994 195. Konttinen YT, Häyrinen-Immonen R, Nordström D, Malmström MJ, Hukkanen M, Sorsa T, Polak JM: Innervation of recurrent aphthous ulcers. Oral Microbiol Immunol 9:60-64, 1994 196. Nordström D, Santavirta S, Antti-Poika I, Konttinen YT: Local immune-inflammatory response to infected total hip and knee replacements. Arch Orthop Trauma Surg 113:159-163, 1994 197. Törnwall J, Uusitalo H, Konttinen YT: The distribution and origin of nerve fibers immunoreactive for substance P and neurokinin A in the anterior buccal gland of the rat. Cell Tissue Res 277:309-313, 1994 198. Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT: Multiple forms of gelatinases / type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J Clin Periodontol 21:26-31, 1994 199. Törnwall J, Uusitalo H, Hukkanen M, Sorsa T, Konttinen YT: Distribution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjögren's syndrome and in normal controls. Clin Exp Rheumatol 12:287-292, 1994 200. Santavirta N, Lillqvist G, Sarvimäki A, Honkanen V, Konttinen YT, Santavirta S: Teaching of patients undergoing total hip replacement surgery. Int J Nurs Stud 31:135-142, 1994 201. Ingman T, Könönen M, Konttinen YT, Siirilä HS, Suomalainen K, Sorsa T: Collagenase, gelatinase and elastase activities in sulcular fluid of osteointegrated implants and natural teeth. J Clin Periodontol 21:301-307, 1994 202. Nordsletten L, Madsen JE, Almaas R, Rootwelt T, Halse J, Konttinen YT, Hukkanen M, Santavirta S: The neuronal regulation of fracture healing. Effects of sciatic nerve resection in rat tibia. Acta Orthop Scand 65:299-304, 1994

203. Konttinen YT, Kangaspunta P, Lindy O, Takagi M, Sorsa T, Segerberg M, Tschesche H, Eisen AZ: Collagenase in Sjögren's syndrome. Ann Rheum Dis 53:836-839, 1994 204. Lauhio A, Konttinen YT, Tschesche H, Nordström D, Salo T, Lähdevirta J, Golub LM, Sorsa T: Reduction of matrix metalloproteinase-8 neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. Antimicrobial Agents Chemother 38:400-402, 1994 205. Häyrinen-Immonen R, Sorsa T, Pettilä J, Konttinen YT, Teronen O, Malmström M: Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. J Oral Pathol Med 23:269-272, 1994 206. Lauhio A, Konttinen YT, Salo T, Tschesche H, Nordström D, Lähdevirta J, Golub LM, Sorsa T: The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis. Ann NY Acad Sci 732:431-432, 1994 207. Ingman T, Sorsa T, Kangaspunta P, Konttinen YT: Elastase and α1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis. J Periodontol 65:702-709, 1994 208. Ingman T, Sorsa T, Michaelis J, Konttinen YT: Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis. Scand J Dent Res 102:342-349, 1994 209. Nordström D, Santavirta S, Seitsalo S, Hukkanen M, Polak JM, Nordsletten L, Konttinen YT: Symptomatic lumbal spondylolysis: neuroimmunological studies. Spine 19:2752-2758, 1994 210. Takagi M, Konttinen YT, Santavirta S, Sorsa T, Eisen AZ, Nordsletten L, Suda A: Extracellular matrix metalloproteinases around loose total hip prosthesis. Acta Orthop Scand 65:281-286, 1994 211. Sepper R, Konttinen YT, Sorsa T, Koski H: Gelatinolytic and type IV collagenolytic activity in bronchiectasis. Chest 106:1129-1133, 1994 212. Luukko M, Konttinen YT, Kemppinen P, Pertovaara A: Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rats. Exp Neurol 128:1-12, 1994 213. Takagi M, Konttinen YT, Lindy O, Sorsa T, Kurvinen H, Suda A, Santavirta S: Gelatinase / type IV collagenases in the loosening of total hip replacement endoprosthesis. Clin Orthop Rel Res 306:136-144, 1994 214. Ding Y, Liede K, Leppä S, Ingman T, Sepper R, Konttinen YT, Sorsa T: Gingival crevicular fluid and salivary matrix metalloproteinases of heavy smokers as indicators of periodontal health. Ann NY Acad Sci 732:453-455, 1994 215. Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT: Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases. Ann NY Acad Sci 732:112-131, 1994 216. Lauhio A, Salo T, Ding Y, Konttinen YT, Nordström D, Tschesche H, Lähdevirta J, Golub LM, Sorsa T: In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. Clin Exp Immunol 98:21-28, 1994 217. Baudet-Pommel M, Albuisson E, Kemeny JL, Falvard F, Ristori JM, Fraysse MP, Sauvezie B, Vitali C, Bombardieri S, Bencivelli W, de Vita S, Sciuto M, Moutsopoulos HM, Drosos AA, Skopouli FN, Balestrieri G, Braga S, Bernstein RM, Hay EM, Bjerrum KB, Prause JU, Schiodt M, Coll J, Ehrenfeld M, Shoenfeld Y, Hatron PY, Janin A, Isenberg DA, Snaith ML, Maini RN, Venables PJW, Kalden JR, Kater L, Konttinen YT, Maddisson PJ, Manthorpe R, Meyer O, Wattiaux MJ, Ostuni P, Todesco S, Pennec Y, Youinou P, Richards A, Scully C, Sauvezie B, Smolen JS, Tishler M, Valesini G: Early dental loss in Sjögren s syndrome. Histologic correlates. Oral Surg Oral Med Oral Pathol 78:181-186, 1994 218. Vitali C, Moutsopoulos HM, Bombardieri S, and the European Community Study Group on Diagnostic Criteria for Sjögren's Syndrome: Sensitivity and specificity of tests for ocular and oral involvement in Sjögren's syndrome. Ann Rheum Dis 53:637-647, 1994 219. Takagi M, Konttinen YT, Kemppinen P, Sorsa T, Tschesche H, Bläser J, Suda A, Santavirta S: Tissue inhibitor of metalloproteinase 1 and collagenolytic and gelatinolytic activity in loose hip endoprostheses. J Rheumatol 22:2285-2290, 1995

220. Sorsa T, Ding Y, Ingman T, Salo T, Westerlund U, Haapasalo M, Tschesche H, Konttinen YT: Cellular source, activation and inhibition of dental plaque collagenase. J Clin Periodontol 22:709-717, 1995 221. Tervahartiala T, Ingman T, Sorsa T, Ding Y, Kangaspunta P, Konttinen YT: Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjögren's syndrome. Eur J Oral Sci 103:11-16, 1995 222. Takagi M, Konttinen YT, Santavirta S, Kangaspunta P, Sorsa T, Suda A, Rokkanen P: Cathepsin G and α1-antitrypsin in the local host reaction to loosening of total hip prosthesis. J Bone Joint Surg (Am) 77A:16-25, 1995 223. Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L, Madsen JE, Almaas R, Oestreicher AB, Rootwelt T, Polak JM: Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Rel Res 311:247-257, 1995 224. Takagi M, Konttinen YT, Santavirta S, Kangaspunta P, Sorsa T, Yamakawa M, Suda A: Elastase activity, uninhibited by α1-antitrypsin, in the periprosthetic connective tissue matrix around loose total hip prostheses. J Orthopaed Res 13:296-304, 1995 225. Golub LM, Sorsa T, Lee H-M, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT: Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 22:100-109, 1995 226. Sepper R, Konttinen YT, Ingman T, Sorsa T: Presence, activitites, and molecular forms of cathepsin G, elastase, α1-antitrypsin and α1-antichymotrypsin in bronchiectasis. J Clin Immunol 15:27-34, 1995 227. Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T: Human neutrophil collagenase (MMP-8), identified in bronciectasis BAL fluid, correlates with severity of disease. Chest 107:1641-1647, 1995 228. Teronen O, Salo T, Konttinen YT, Rifkin B, Vernillo A, Ramamurthy NS, Kjeldsen L, Borregaard N, Hietanen J, Sorsa T: Identification and characterization of gelatinases/type IV collagenases in jaw cysts. J Oral Pathol Med 24:78-84, 1995 229. Nordström D, Honkanen VEA, Nasu Y, Antila E, Friman C, Konttinen YT: Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 14:231-234, 1995 230. Teronen O, Salo T, Laitinen J, Törnwall J, Ylipaavalniemi P, Konttinen YT, Hietanen J, Sorsa T: Characterization of interstitial collagenases in jaw cyst wall. Eur J Oral Sci 103:141-147, 1995 231. Sukura A, Konttinen YT, Sepper R, Lindberg L-A: Recovery from Pneumocystis carinii pneumonia in dexamethasone-treated Wistar rats. Eur Respir J 8:701-708, 1995 232. Sukura A, Konttinen YT, Sepper R, Kaartinen L, Sorsa T, Lindberg L-A: Collagenases and serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia. J Clin Microbiol 33:829-834, 1995 233. Kilpi A, Rich AM, Konttinen YT, Reade PC: The expression of c-erbb2 protein in the keratinocytes of oral mucosal lichen planus. Brit J Dermatol 133:847-852, 1995 234. Koski H, Konttinen YT, Xu-Hong G, Hietanen J, Malmström M: Transforming growth factor β2 in labial salivary glands in Sjögren's syndrome. Ann Rheum Dis 54:744-747, 1995 235. Törnwall J, Konttinen YT, Hietanen J, Sorsa T, Hukkanen M, Uusitalo H: VIP in salivary glands in Sjögren's syndrome. Brit J Rheumatol 34:891-893, 1995 236. Ding Y, Uitto V-J, Firth J, Salo T, Haapasalo M, Konttinen YT, Sorsa T: Modulation of matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases. Oral Dis 1:279-286, 1995 237. Törnwall J, Konttinen YT, Uusitalo H: Immunohistochemical distribution of calcitonin generelated peptide in nerve fibers of the anterior buccal gland of the rat. Histochem J 28:1-5, 1996 238. Nordsletten L, Buø L, Takagi M, Konttinen YT, Yamakawa M, Santavirta S, Aasen AO: The plasminogen activation system is upregulated in loosening of total hip prostheses. Acta Orthop Scand 67:143-148, 1996 239. Tervahartiala T, Konttinen YT, Ingman T, Häyrinen-Immonen R, Ding Y, Sorsa T: Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis. J Clin Periodontol 23:68-75, 1996 240. Nordström D, Lindy O, Konttinen YT, Lauhio A, Sorsa T, Friman C, Pettersson T, Santavirta S: Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis. Clin Rheumatol 15:35-41, 1996

241. Solovieva SA, Čeponis A, Konttinen YT, Takagi M, Suda A, Eklund KK, Sorsa T, Santavirta S: Mast cells in loosening of totally replaced hips. Clin Orthop Rel Res 322:158-165, 1996 242. Konttinen YT, Kurvinen H, Takagi M, Michelsson J-E, Eklund KK, Nordsletten L, Buø L, Aasen AO, Santavirta S: IL-1 and collagenases around loosening total hip prosthesis. Clin Exp Rheumatol 14:255-262, 1996 243. Santavirta S, Čeponis A, Solovieva SA, Hurri H, Jin J, Takagi M, Suda A, Konttinen YT: Periprosthetic microvasculature in loosening of total hip replacement. Arch Orthop Traum Surg 115:286-289, 1996 244. Čeponis A, Konttinen YT, Mackevičius Z, Solovieva SA, Hukkanen M, Tamulaitienė M, Matulis A, Santavirta S: Aberrant vascularity and von Willebrand factor distribution in inflamed synovial membrane. J Rheumatol 23:1880-1886, 1996 245. Westerlund U, Ingman T, Lukinmaa P-L, Salo T, Kjeldsen L, Borregaard N, Tjäderhane L, Konttinen YT, Sorsa T: Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis. J Dent Res 75:1553-1563, 1996 246. Santavirta N, Björvell H, Koivumäki E, Hurskainen K, Solovieva S, Konttinen YT: The factor structure of coping strategies in hemophilia. J Psychosom Res 40:617-624, 1996 247. Santavirta N, Björvell H, Konttinen YT, Solovieva S, Poussa M, Santavirta S: Sense of coherence and outcome of anterior low-back fusion. A 5 to 13-year follow-up of 85 patients. Arch Orthop Trauma Surg 115:280-285, 1996 248. Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane D, Konttinen YT, Sorsa T: Matrix metalloproteinases and their tissue inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 23:1127-1132, 1996 249. Teronen O, Salo T, Hietanen J, Eklund KK, Sommerhoff CP, Sorsa T, Konttinen YT: Mast cellderived tryptase in odontogenic cysts. J Oral Pathol Med 25:376-381, 1996 250. Santavirta N, Björvell H, Solovieva S, Santavirta S, Hurskainen K, Konttinen YT: Empirically derived classification of coagulation disorders in 224 patients. Haematologica 81:316-323, 1996 251. Immonen I, Konttinen YT, Sorsa T, Tommila P, Sirén V: Proteinases in subretinal fluid. Graef Arch Clin Exp Ophthal 234:105-109, 1996 252. Mellanen L, Ingman T, Lähdevirta J, Lauhio A, Ainamo A, Konttinen YT, Sukura A, Salo T, Sorsa T: Matrix metalloproteinases -1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection. Oral Dis 2:263-271, 1996 253. Ding Y, Uitto V-J, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, Grenier D, Sorsa T: Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res 75:1986-1993, 1996 254. Santavirta S, Takagi M, Konttinen YT, Sorsa T, Suda A: Inhibitory effect of cephalothin on matrix metalloproteinase activity around loose hip prostheses. Antimicrobial Agents Chemother 40:244-246, 1996 255. Nordsletten L, Høgåsen AKM, Konttinen YT, Santavirta S, Aspenberg P, Aasen AO: Human monocytes stimulation by particles of hydroxyapatite, silicon carbide and diamond: in vitro studies of new prosthesis coatings. Biomaterials 17:1521-1527, 1996 256. Weckroth M, Vaheri A, Lauharanta J, Sorsa T, Konttinen YT: Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. J Invest Dermatol 106:1119-1124, 1996 257. Nordström D, Konttinen YT, Solovieva SA, Friman C, Santavirta S: In- and out-patient rehabilitation in rheumatoid arthritis. A controlled, open, longitudinal, cost-effectiveness study. Scand J Rheumatol 25:200-206, 1996 258. Konttinen YT, Törnwall J, Kemppinen P, Uusitalo H, Sorsa T, Hukkanen M, Polak JM: Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjögren's syndrome. Ann Rheum Dis 55:513-519, 1996 259. Xu J-W, Konttinen YT, Lassus J, Natah S, Čeponis A, Solovieva S, Aspenberg P, Santavirta S: Tumor necrosis factor-alpha (TNF-α) in loosening of total hip replacement (THR). Clin Exp Rheumatol 14:643-648, 1996 260. Vitali C, Bombardieri S, Moutsopoulos HM, Coll J, Gerli R, Hatron PY, Kater L, Konttinen YT, Manthorpe R, Meyer O, Mosca M, Ostuni P, Pellerito RA, Pennec Y, Porter SR, Richards A, Sauvezie B, Schiødt M, Sciuto M, Shoenfeld Y, Skopouli FN, Smolen JS, Soromenho F, Tishler M, Tomsic M, van de Merwe JP, Yeoman CM, Wattiaux MJ. Assessment of the European

classification criteria for Sjögren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. Ann Rheum Dis 55:116-121, 1996 261. Konttinen YT, Čeponis A, Meri S, Vuorikoski A, Kortekangas P, Sorsa T, Sukura A, Santavirta S: Complement in acute and chronic arthritides. Assessment of C3c, C9 and protectin (CD59) in synovial membrane. Ann Rheum Dis 55:888-894, 1996 262. Kilpi A, Rich AM, Konttinen YT, Reade PC: Expression of c-erbb-2 protein in keratinocytes of oral mucosal lichen planus and subsequent squamous cell carcinoma. Eur J Oral Sci 104:278-284, 1996 263. Waris V, Xu JW, Nordsletten L, Sorsa T, Santavirta S, Konttinen YT: Basic fibroblast growth factor (bfgf) in the synovial-like membrane around loose total hip prostheses. Scand J Rheumatol 25:257-262, 1996 264. Xu JW, Konttinen YT, Waris V, Barrena EG, Sorsa T, Santavirta S: Granulocyte-macrophage colony stimulating factor in the aseptic loosening of total hip arthroplasty. J Orthop Rheumatol 9:128-134, 1996 265. Kilpi A, Rich AM, Reade PC, Konttinen YT: Studies of the inflammatory process and malignant potential of oral mucosal lichen planus. Aust Dent J 41:87-90, 1996 266. Kauppi M, Sakaguchi M, Konttinen YT, Hämäläinen M, Hakala M: Pathogenetic mechanism and prevalence of the stable atlantoaxial subluxation in rheumatoid arthritis. J Rheumatol 23:831-834, 1996 267. Madsen JE, Aune AK, Falch JA, Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L: Neural involvement in post-traumatic osteopenia: an experimental study in the rat. Bone 18:411-416, 1996 268. Madsen JE, Wang J-S, Hukkanen M, Nordsletten L, Konttinen YT, Santavirta S, Polak JM, Aspenberg P: Sensory nerve ingrowth during bone graft incorporation in the rat. Acta Orthop Scand 67:217-220, 1996 269. Halinen S, Sorsa T, Ding Y, Ingman T, Salo T, Konttinen YT, Saari H: Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down s syndrome. J Periodontol 67:748-754, 1996 270. Aspenberg P, Anttila A, Konttinen YT, Lappalainen R, Goodman SB, Nordsletten L, Santavirta S: Benign response to particles of diamond and SiC: bone chamber studies of new joint replacement coating materials in rabbits. Biomaterials 17:807-812, 1996 271. Xu JW, Konttinen YT, Waris V, Pätiälä H, Sorsa T, Santavirta S: Macrophage-colony stimulating factor (M-CSF) is increased in the synovial-like membrane of the periprosthetic tissues in the aseptic loosening of total hip replacement (THR). Clin Rheumatol 16:243-248, 1997 272. Saari H, Halinen S, Ganlöv K, Sorsa T, Konttinen YT: Salivary mucous glycoprotein MG1 in Sjögren's syndrome. Clin Chim Acta 259:83-96, 1997 273. Santavirta N, Konttinen YT, Törnwall J, Segerberg M, Santavirta S, Matucci-Cerinic M, Björvell H: Neuropeptides of the autonomic nervous system in Sjögren's syndrome. Ann Rheum Dis 56:737-740, 1997 274. Koivunen A-L, Maisi P, Konttinen YT, Sandholm M: Gelatinolytic activity in tracheal aspirates of horses with chronic pulmonary disease. Acta Vet Scand 38:17-27, 1997 275. Sepper S, Konttinen YT, Buø L, Eklund KK, Lauhio A, Sorsa T, Tschesche H, Aasen AO, Sillastu H: Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (prommp-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. Eur Respir J 10:2788-2793, 1997 276. Virtanen T, Konttinen YT, Honkanen N, Härkönen M, Tervo T: Tear fluid plasmin activity of dry eye patients with Sjögren's syndrome. Acta Ophthalmol Scand 75:137-141, 1997 277. Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T: Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate. J Dent Res 76:1529-1537, 1997 278. Konttinen YT, Waris V, Xu JW, Jiranek WA, Sorsa T, Virtanen I, Santavirta S: Transforming growth factor-β 1 and 2 in the synovial-like membrane between the implant and bone in loosening of total hip arthroplasty. J Rheumatol 24:694-701, 1997 279. Koski H, Konttinen YT, Hietanen J, Tervo T, Malmström M: Epidermal growth factor, transforming growth factor-α, and epidermal growth factor receptor in labial salivary glands in Sjögren's syndrome. J Rheumatol 24:1930-1935, 1997

280. Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Valleala H, Sorsa T: Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate). Calcified Tissue Int 61:59-61, 1997 281. Sorsa T, Salo T, Koivunen E, Tyynelä J, Konttinen YT, Bergmann U, Tuuttila A, Niemi E, Teronen O, Heikkilä P, Tschesche H, Leinonen J, Osman S, Stenman U-H: Activation of type IV procollagenases by human tumor-associated trypsin-2. J Biol Chem 272:21067-21074, 1997 282. Koivunen A-L, Maisi P, Konttinen YT, Prikk K, Sandholm M: Collagenolytic activity and its sensitivity to doxycycline inhibition in tracheal aspirates of horses with chronic obstructive pulmonary disease. Acta Vet Scand 38:9-16, 1997 283. Konttinen YT, Platts LAM, Tuominen S, Eklund KK, Santavirta N, Törnwall J, Sorsa T, Hukkanen M, Polak JM: Role of nitric oxide in Sjögren's syndrome. Arthritis Rheum 40:875-883, 1997 284. Lindy O, Konttinen YT, Sorsa T, Ding Y, Santavirta S, Čeponis A, López-Otín C: Matrix metalloproteinase 13 (collagenase-3) in human rheumatoid synovium. Arthritis Rheum 40:1391-1399, 1997 285. Imai S, Tokunaga Y, Konttinen YT, Maeda T, Hukuda S, Santavirta S: Ultrastructure of the synovial sensory peptidergic fibers is distinctively altered in different phases of adjuvant induced arthritis in rats: ultramorphological characterization combined with morphometric and immunohistochemical study for substance P, calcitonin gene related peptide, and protein gene product 9.5. J Rheumatol 24:2177-2187, 1997 286. Imai S, Konttinen YT, Tokunaga Y, Maeda T, Hukuda S, Santavirta S: An ultrastructural study of calcitonin gene-related peptide-immunoreactive nerve fibers innervating the rat posterior longitudinal ligament. A morphologic basis for their possible efferent actions. Spine 22:1941-1947, 1997 287. Imai S, Konttinen YT, Tokunaga Y, Maeda T, Hukuda S, Santavirta S: Tyrosine hydroxylaseimmunoreactive nerve fibres in rat posterior longitudinal ligament. J Autonom Nerv Syst 63:51-60, 1997 288. Hukkanen M, Corbett SA, Batten J, Konttinen YT, McCarthy I, Santavirta S, Hughes SPF, Polak JM: Aseptic loosening of total hip replacement: macrophage expression of inducible nitric oxide synthase and cycloo-xygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure. J Bone Joint Surg (Br) 79:467-474, 1997 289. Imai S, Rauvala H, Konttinen YT, Tokunaga T, Maeda T, Hukuda S, Santavirta S: Efferent targets of osseous CGRP-immunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat: an ultramorphological study on their terminal-target relations. J Bone Miner Res 12:1018-1027, 1997 290. Törnwall J, Konttinen YT, Tuominen RK, Törnwall M: Protein kinase C expression in salivary gland acinar epithelial cells in Sjögren s syndrome. Lancet 349:1814-1815, 1997 291. Hanemaaijer R, Sorsa T, Konttinen YT, Ding Y, Sutinen M, Visser H, van Hinsbergh VWM, Helaakoski T, Kainulainen T, Rönkä H, Tschesche H, Salo T: Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-α and doxycycline. J Biol Chem 272:31504-31509, 1997 292. Natah SS, Häyrinen-Immonen R, Hietanen J, Malmström M, Konttinen YT: Factor XIIIa-positive dendrocytes are increased in number and size in recurrent aphthous ulcers (RAU). J Oral Pathol Med 26:408-413, 1997 293. Wilkman TSE, Hietanen JHP, Malmström MJ, Konttinen YT: Immunohistochemical analysis of the oncoprotein c-erbb-2 expression in oral benign and malignant lesions. Int J Oral Maxillofac Surg, 27:209-212, 1998 294. Santavirta S, Xu JW, Hietanen J, Čeponis A, Sorsa T, Kontio R, Konttinen YT: Activation of periprosthetic connective tissue in aseptic loosening of total hip replacements. Clin Orthop Rel Res, 352:16-24, 1998 295. Mellanen L, Salo T, Ingman T, Konttinen YT, Lähdevirta J, Sorsa T: 72-kD and 92-kD gelatinases in saliva of patients with human immunodeficiency virus infection. Acta Odont Scand 56:135-142, 1998 296. Natah S, Häyrinen-Immonen R, Hietanen J, Malmström M, Larsson Å, Konttinen YT: Quantitative assessment of mast cells in recurrent aphthous ulcers (RAU). J Oral Pathol Med 27:124-129, 1998

297. Natah SS, Hietanen J, Häyrinen-Immonen R, Jungell P, Malmström M, Konttinen YT: Expression of cell proliferation-associated nuclear antigen (Ki-67) in recurrent aphthous ulcers (RAU). Oral Med Pathol 3:29-34, 1998 298. Xu JW, Konttinen YT, Li TF, Waris V, Lassus J, Matucci-Cerinic M, Sorsa T, Santavirta S: Production of platelet-derived growth factor in aseptic loosening of total hip replacement. Rheumatol Int 17:215-221, 1998 299. Čeponis A, Konttinen YT, Imai S, Tamulaitienė M, Li T-F, Xu J-W, Hietanen J, Santavirta S, Fassbender HG: Synovial lining, endothelial and inflammatory mononuclear cell proliferation in synovial membranes in psoriatic and reactive arthritis: a comparative quantitative morphometric study. Brit J Rheumatol 37:170-178, 1998 300. Konttinen YT, Li T-F, Michelsson O, Xu J-W, Sorsa T, Santavirta S, Imai S, Virtanen I: Expression of tenascin-c in aseptic loosening of total hip replacement. Ann Rheum Dis 57:619-623, 1998 301. Ohnishi K, Takagi M, Kurokawa Y, Satomi S, Konttinen YT: Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 78:1077-1087, 1998 302. Čeponis A, Konttinen YT, Takagi M, Xu J-W, Sorsa T, Matucci-Cerinic M, Santavirta S, Bankl H- C, Valent P: Expression of stem cell factor (SCF) and SCF receptor (c-kit) in synovial membrane in arthritis: correlation with synovial mast cell hyperplasia and inflammation. J Rheumatol 25:2304-2314, 1998 303. Nordström D, Lindy O, Lauhio A, Sorsa T, Santavirta S, Konttinen YT: Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis. Rheumatol Int 17:175-180, 1998 304. Santavirta S, Takagi M, Nordsletten L, Anttila A, Lappalainen R, Konttinen YT: Biocompatibility of silicon carbide in colony formation test in vitro. A promising new ceramic THR implant coating material. Arch Orthop Trauma Surg 118:89-91, 1998 305. Imai S, Konttinen YT, Jumppanen M, Lindy O, Čeponis A, Kemppinen P, Sorsa T, Santavirta S, Xu J-W, Lopéz-Otín C: High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign body reaction. J Bone Joint Surg (Br) 80-B:701-710, 1998 306. Konttinen YT, Čeponis A, Takagi M, Ainola M, Sorsa T, Sutinen M, Salo T, Ma J, Santavirta S, Seiki M: New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above. Matrix Biol 17:585-601, 1998 307. Sorsa T, Ramamurthy NS, Vernillo AT, Zhang X, Konttinen YT, Rifkin BR, Golub LM: Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases. J Rheumatol 25:975-982, 1998 308. Konttinen YT, Halinen S, Hanemaaijer R, Sorsa T, Hietanen J, Čeponis A, Xu J-W, Manthorpe R, Whittington J, Larsson Å, Salo T, Kjeldsen L, Stenman U-H, Eisen AZ: Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren s syndrome. Matrix Biol 17:335-347, 1998 309. Bjørnland K, Buø L, Scott H, Konttinen YT, Johansen HT, Aasen AO: Polymorphonuclear elastase in human colorectal carcinoma. Int J Oncology 12:535-540, 1998 310. Hanemaaijer R, Visser H, Konttinen YT, Koolwijk P, Verheijen J: A novel and simple immunocapture assay for determination of gelatinase-b (MMP-9) activities in biological fluids: saliva from patients with Sjögren s syndrome contain increased latent and active gelatinase-b levels. Matrix Biol 17:657-665, 1998 311. Hukkanen M, Corbett SA, Platts LAM, Konttinen YT, Santavirta S, Hughes SPF, Polak JM: Nitric oxide in the local host reaction to total hip replacement. Clin Orthop Rel Res 352:53-65, 1998 312. Xu J-W, Li T-F, Partsch G, Čeponis A, Santavirta S, Konttinen YT: Interleukin-11 (IL-11) in aseptic loosening of total hip replacement (THR). Scand J Rheumatol 27:363-367, 1998 313. Matucci-Cerinic M, Generini S, Partsch G, Pignone A, Dini G, Konttinen YT, Del Rosso M: Synoviocytes from osteoarthritis and rheumatoid arthritis produce plasminogen activators and plasminogen activator inhibitor-1 and display u-pa receptors on their surface. Life Sci 63:441-453, 1998 314. Takagi M, Santavirta S, Ida H, Ishii M, Akimoto K, Saotome K, Konttinen YT: The membranetype-matrix metalloproteinase/ matrix metalloproteinase-2/ tissue inhibitor of metalloproteinase-2

system in periprosthetic connective-tissue remodeling in loose total-hip prostheses. Lab Invest 78:735-742, 1998 315. Sepper R, Konttinen YT, Kemppinen P, Sorsa T. Eklund KK: Mast cells in bronchiectasis. Ann Med 30:307-315, 1998 316. Konttinen YT, Kääpä E, Hukkanen M, Gu X, Takagi M, Santavirta S, Alaranta H, Li TF, Suda A: Cathepsin G in degenerating and healthy discal tissue. Clin Exp Rheumatol 17:197-204, 1999 317. Arborelius M Jr, Konttinen YT, Nordström DC, Solovieva SA: Gly-X-Y repeat sequences in the treatment of active rheumatoid arthritis. Rheumatol Int 18:129-135, 1999 318. Nordström D, Santavirta S, Aho A, Heikkilä J, Teppo AM, Konttinen YT: Immune responses to osteoarticular allografts of the knee - cytokine studies. Arch Orthop Trauma Surg 119:195-198, 1999 319. Vujisić S, Stefanović V, Kupešić S, Kurjak A, Lackovic G, Koski H, Konttinen YT: Immunohistochemical localization of epidermal growth factor and its receptor in differently mature endometrium of mid-luteal phase. Periodicum biologorum 101:65-70, 1999 320. Konttinen YT, Kemppinen P, Koski H, Li T-F, Jumppanen M, Hietanen J, Santavirta S, Salo T, Larsson Å, Hakala M, Sorsa T: TH1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals. Scand J Rheumatol 28:106-112, 1999 321. Koivunen E, Arap W, Valtanen H, Rainisalo A, Medina OP, Heikkilä P, Kantor C, Gahmberg CG, Salo T, Konttinen YT, Sorsa T, Ruoslahti E, Pasqualini R: Tumor targeting with a selective gelatinase inhibitor. Nature Biotechnology 17:768-774, 1999 322. Konttinen YT, Kemppinen P, Li T-F, Waris E, Pihlajamäki H, Sorsa T, Takagi M, Santavirta S, Schultz GS, Humphreys-Beher MG: Transforming and epidermal growth factors in degenerated intervertebral discs. J Bone Joint Surg (Br) 81-B:1058-1063, 1999 323. Takei I, Takagi M, Konttinen YT, Santavirta S, Ida H, Hamasaki M, Ishii M, Fukushima S, Ogino T: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in joint fluid of the patients with loose artificial hip joints J Biomed Mater Res 45:175-183, 1999 324. Laine J, Konttinen YT, Beliaev N, Happonen R-P: Immunocompetent cells in amalgam-associated oral lichenoid contact lesions. J Oral Pathol Med 28:117-121, 1999 325. Tulikoura I, Lassus J, Konttinen YT, Juutilainen T, Santavirta S: A safe surgical technique for the partial resection of the ruptured spleen. A clinical report. Injury 30:693-697, 1999 326. Konttinen YT, Salo T, Hanemaaijer R, Valleala H, Sorsa T, Sutinen M, Čeponis A, Xu J-W, Santavirta S, Teronen O, López-Otín C: Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus - hard tissue junction and inhibition by alendronate. Matrix Biol 18:401-412, 1999 327. Čeponis A, Hietanen J, Tamulaitienė M, Partsch G, Pätiälä H, Konttinen YT: A comparative quantitative morphometric study of cell apoptosis in syovial membranes in psoriatic, reactive and rheumatoid arthritis. Rheumatology 38:431-440, 1999 328. Konttinen YT, Li T-F, Xu J-W, Takagi M, Pirilä L, Silvennoinen T, Santavirta S, Virtanen I: Expression of laminins and their integrin receptors in different conditions of synovial membrane and synovial membrane-like interface tissue. Ann Rheum Dis 58:683-690, 1999 329. Santavirta S, Lappalainen R, Pekko P, Anttila A, Konttinen YT: The counterface, surface smoothness, tolerances and coatings in total joint prostheses. Clin Orthop Rel Res 369:92-102, 1999 330. Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, López-Otín C, Takagi M: Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 58:691-697, 1999 331. Li T-F, Santavirta S, Virtanen I, Könönen M, Takagi M, Konttinen YT: Increased expression of EMMPRIN in the tissue around loosened hip prostheses. Acta Orthop Scand 70:446-451, 1999 332. De Bernabé DB, Peterson P, Luopajärvi K, Matintalo P, Alho A, Konttinen Y, Krohn K, de Córdoba SR, Ranki A: Mutational analysis of the HGO gene in Finnish alkaptonuria patients. J Med Genet 36:922-923, 1999 333. Anttila A, Lappalainen R, Heinonen H, Santavirta S, Konttinen YT: Superiority of diamondlike carbon coating on articulating surfaces of artificial hip joint. New Diamond and Frontier Carbon Technology 9:283-288, 1999

334. Konttinen YT, Hietanen J, Virtanen I, Ma J, Sorsa T, Xu J-W, Williams NP, Manthorpe R, Janin A: Mast cell derangement in salivary glands in patients with Sjögren's syndrome. Rheumatol Int 19:141-147, 2000 335. Teronen O, Laitinen M, Salo T, Hanemaaijer R, Heikkilä P, Konttinen YT, Sorsa T: Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma (letter). Blood 96:4006-4007, 2000 336. Konttinen YT, Ramsay H, Hietanen J, Sorsa T, Nordström D: Otitis externa sicca/fibrotising external otitis (FEO) as a complication of Sjögrens syndrome. Clin Exp Rheumatol 18:746-748, 2000 337. Santavirta S, Valtonen M, Pätiälä H, Saarinen O, Konttinen YT: Disseminated hydatid disease causing paraplegia and destruction of the hip. Arch Orthop Trauma Surg 120:118-120, 2000 338. Lassus J, Tulikoura I, Konttinen YT, Santavirta S: Treatment of infection and non-union after bilateral complicated proximal tibial fracture. Ann Chir Gynaecol 89:325-328, 2000 339. Lassus J, Waris V, Xu J-W, Li T-F, Hao J, Nietosvaara Y, Santavirta S, Konttinen YT: Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement. Arch Orthop Trauma Surg 120:328-332, 2000 340. Li T-F, Xu J-W, Santavirta S, Nordsletten L, Michelsson O, Takagi M, Virtanen I, Konttinen YT: Distribution of fibronectins and their integrin receptors in interface tissue from aseptic loosening of hip protheses. Clin Exp Rheumatol 18:221-225, 2000 341. Niissalo S, Hietanen J, Malmström M, Hukkanen M, Polak JM, Konttinen YT: Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions. J Oral Pathol Med 29:361-369, 2000 342. Takei I, Takagi M, Santavirta S, Ida H, Ishii M, Ogino T, Ainola M, Konttinen YT: Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints. J Biomed Mater Res 52:613-620, 2000 343. Valleala H, Teronen O, Friman C, Sorsa T, Solovieva SA, Konttinen YT: Inhibition of collagenase by a bisphosphonate-group drug in patients with rheumatoid arthritis. J Rheumatol 27:1570-1572, 2000 344. Konttinen YT, Li T-F, Mandelin J, Liljeström M, Sorsa T, Santavirta S, Virtanen I: Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium. Arthritis Rheum 43:275-280, 2000 345. Xu JW, Ma J, Li TF, Waris E, Alberty A, Santavirta S, Konttinen YT: Expression of epidermal growth factor and transforming growth factor α in interfacial membranes retrieved at revision total hip arthroplasty. Ann Rheum Dis 59:822-827, 2000 346. Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT: Collagenases in different categories of peri-implant vertical bone loss. J Dent Res 79:1870-1873, 2000 347. Collin HL, Sorsa T, Meurman JH, Niskanen L, Salo T, Rönkä H, Konttinen YT, Koivisto AM, Uusitupa M: Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus. J Periodontal Res 35:259-265, 2000 348. Takei I, Takagi M, Ida H, Ogino T, Santavirta S, Konttinen YT: High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints. J Rheumatol 27:894-899, 2000 349. Li TF, Xu JW, Santavirta S, Takagi M, Virtanen I, Pirilä L, Konttinen YT: Expression of vitronectin and its integrin receptors in the synovial membrane-like interface tissue from aseptic loosening of total hip replacement. J Rheumatol 27:727-734, 2000 350. Hokynar K, Brunstein J, Söderlund-Venermo M, Kiviluoto O, Partio EK, Konttinen Y, Hedman K: Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue. J Virol Genet 81:1017-1025, 2000 351. Li TF, Waris V, Ma J, Lassus J, Yoshida T, Santavirta S, Virtanen I, Konttinen YT: Distribution of tenascin-x in different synovial samples and synovial membrane-like interface tissue from aseptic loosening of total hip replacement. Rheumatol Int 19:177-183, 2000 352. Kääpä E, Wang W, Takala TE, Poussa M, Konttinen YT, Lammi MJ, Vanharanta H: Elevated protein content and prolyl 4-hydroxylase activity in severely degenerated human annulus fibrosus. Connect Tissue Res 41:93-99, 2000

353. Tervahartiala T, Pirilä E, Čeponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T: The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13 and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res 79:1969-1977, 2000 354. Natah SS, Häyrinen-Immonen R, Hietanen J, Patinen P, Malmström M, Savilahti E, Konttinen YT: Increased density of lymphocytes bearing γ/δ T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 29:375-380, 2000 355. Natah SS, Häyrinen-Immonen R, Hietanen J, Malmström M, Konttinen YT: Immunolocalization of tumor necrosis factor-α expressing cells in recurrent aphthous ulcer lesions (RAU). J Oral Pathol Med 29:19-25, 2000 356. Santavirta S, Björvell H, Solovieva S, Alaranta H, Hurskainen K, Konttinen YT: Coping strategies, pain, and disability in patients with hemophilia and related disorders. Arthritis Rheum 45:48-55, 2001 357. Kontio R, Suuronen R, Salonen O, Paukku P, Konttinen YT, Lindqvist C: Effectiveness of operative treatment of internal orbital wall fracture with polydioxanone implant. Int J Oral Maxillofac Surg 30:278-285, 2001 358. Koski H, Janin A, Humphreys-Beher MG, Sorsa T, Malmström M, Konttinen YT: Tumor necrosis factor-alpha and receptors for it in labial salivary glands in Sjögren s syndrome. Clin Exp Rheumatol 19:131-137, 2001 359. Djouadi K, Nedelec B, Tamouza R, Genin E, Ramasawmy R, Charron D, Delpech M, Laoussadi S, Lopes-Vas AA, Alves HD, Emery P, Griffiths B, Foncin JF, Prud homme JF, Menkes CJ, Kahan A, Konttinen YT, Kramer C, Zeidler H, Kuipers JC, Matucci-Cerinic M, Generini S, Veys E, Devlam K, Torre-Alonso JC, Rodriguez I: Interleukin 1 gene cluster polymorphisms in multiplex families with spondylarthropathies. Cytokine 13:98-103, 2001 360. Takagi M, Santavirta S, Ida H, Ishii M, Takei I, Niissalo S, Ogino T, Konttinen YT: High-turnover periprosthetic bone remodeling and immature bone formation around loose cemented total hip joints. J Bone Miner Res 16:79-88, 2001 361. Konttinen YT, Takagi M, Mandelin J, Lassus J, Salo J, Ainola M, Li TF, Virtanen I, Liljeström M, Sakai H, Kobayashi Y, Sorsa T, Lappalainen R, Demulder A, Santavirta S: Acid attack and cathepsin K in bone resorption around total hip replacement prosthesis. J Bone Min Res 16:1780-1786, 2001 362. Konttinen YT, Li TF, Mandelin J, Ainola M, Lassus J, Virtanen I, Santavirta S, Tammi M, Tammi R: Hyaluronan synthases, hyaluronan and its CD44 receptor in tissue around loosened total hip prostheses. J Pathol 194:384-390, 2001 363. Konttinen YT, Li TF, Lassus J, Waris V, Santavirta S, Virtanen I: Removal of hyaline articular cartilage reduces lymphocyte infiltration and activation in rheumatoid synovial membrane. J Rheumatol 28:2184-2189, 2001 364. Pirilä L, Aho H, Roivainen A, Konttinen YT, Pelliniemi LJ, Heino J: Identification of α6β1 integrin positive cells in synovial lining layer as type B synoviocytes. J Rheumatol 28:478-484, 2001 365. Berthelot JM, Klarlund M, McGonagle D, Bernelot-Moens HJ, Calin A, Harrison B, Schumacher HR, Kaarela K, Drosos A, Hülsemann JL, Koh WH, Konttinen YT, Punzi L, Tanimoto K, Williams HJ, Wolfe F, Zebrini CA, Saraux A: Lessons from an international survey of paper cases of 10 real patients from an early arthritis clinic. CRI (Club Rhumatismes et Inflammation) Group. J Rheumatol 28:975-981, 2001 366. Tensing EK, Solovieva SA, Tervahartiala T, Nordström DC, Laine M, Niissalo S, Konttinen YT: Fatigue and health profile in sicca syndrome of Sjögren s and non-sjögren s syndrome origin. Clin Exp Rheumatol 19:313-316, 2001 367. Tervahartiala T, Koski H, Xu JW, Häyrinen-Immonen R, Hietanen J, Sorsa T, Konttinen YT: Tumor necrosis factor-α and its receptors, p55 and p75, in gingiva of adult periodontitis. J Dent Res 80:1535-1539, 2001 368. Čeponis A, Waris E, Mönkkönen J, Laasonen L, Hyttinen M, Solovieva SA, Hanemaaijer R, Bitsch A, Konttinen YT: Effects of low-dose, noncytotoxic, intraarticular liposomal clodronate on development of erosions and proteoglycan loss in established antigen-induced arthritis in rabbits. Arthritis Rheum 44:1908-1916, 2001