LIST OF PUBLICATIONS Terho Heikkinen

1 LIST OF PUBLICATIONS Terho Heikkinen 1. ARTICLES IN INTERNATIONAL PEER-REVIEWED JOURNALS 1.1 Heikkinen T, Ruuskanen O, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media in children. Am J Dis Child 1991;145:445-8. 1.2 Ruuskanen O, Arola M, Heikkinen T, Ziegler T. Viruses in acute otitis media: increasing evidence for clinical significance. Pediatr Infect Dis J 1991;10:425-7. 1.3 Heikkinen T, Ruuskanen O. Temporal development of acute otitis media during upper respiratory tract infection. Pediatr Infect Dis J 1994;13:659-61. 1.4 Ruuskanen O, Heikkinen T. Otitis media: etiology and diagnosis. Pediatr Infect Dis J 1994;13:S23-6. 1.5 Ruuskanen O, Heikkinen T. Viral-bacterial interaction in acute otitis media. Pediatr Infect Dis J 1994;13:1047-9. 1.6 Heikkinen T, Ruuskanen O. Signs and symptoms predicting acute otitis media. Arch Pediatr Adolesc Med 1995;149:26-9. 1.7 Heikkinen T, Ruuskanen O, Ziegler T, Waris M, Puhakka H. Short-term use of amoxicillin clavulanate during upper respiratory tract infection for prevention of acute otitis media. J Pediatr 1995;126:313-6. 1.8 Heikkinen T, Waris M, Ruuskanen O, Putto-Laurila A, Mertsola J. Incidence of acute otitis media associated with group A and B respiratory syncytial virus infections. Acta Paediatr 1995;84:419-23. 1.9 Heikkinen T, Ruuskanen O. New prospects in the prevention of otitis media. Ann Med 1996;28:23-30. 1.10 Chonmaitree T, Heikkinen T. Role of viruses in middle-ear disease. Ann NY Acad Sci 1997;830:143-57. 1.11 Heikkinen T, Ruuskanen O. Otitis media. Curr Opin Pediatr 1998;10:9-12. 1.12 Heikkinen T, Ruohola A, Ruuskanen O, Waris M, Uhari M, Hammarström L. Intranasally administered immunoglobulin for the prevention of rhinitis in children. Pediatr Infect Dis J 1998;17:367-72.

2 1.13 Heikkinen T, Ghaffar F, Okorodudu AO, Chonmaitree T. Serum interleukin-6 in bacterial and nonbacterial acute otitis media. Pediatrics 1998;102:296-9. 1.14 Heikkinen T, Thint M, Chonmaitree T. Prevalence of various respiratory viruses in the middle ear during acute otitis media. N Engl J Med 1999;340:260-4. 1.15 Heikkinen T, Shenoy M, Goldblum RM, Chonmaitree T. Quantification of cytokines and inflammatory mediators in samples of nasopharyngeal secretions with unknown dilution. Pediatr Res 1999;45:230-4. 1.16 Heikkinen T, Shenoy M, Goldblum RM, Chonmaitree T. Free secretory component as a standardization protein for nasopharyngeal specimens from children with upper respiratory tract infection. Acta Paediatr 1999;88:150-3. 1.17 Ruohola A, Heikkinen T, Jero J, Puhakka T, Juvén T, Närkiö-Mäkelä M, Saxén H, Ruuskanen O. Oral prednisolone is an effective adjuvant therapy for acute otitis media with discharge through tympanostomy tubes. J Pediatr 1999;134:459-63. 1.18 Ruohola A, Heikkinen T, Waris M, Puhakka T, Ruuskanen O. Intranasal fluticasone propionate does not prevent acute otitis media during viral upper respiratory infection in children. J Allergy Clin Immunol 2000;106:467-71. 1.19 Heikkinen T, Saeed KA, McCormick DP, Baldwin C, Reisner BS, Chonmaitree T. A single intramuscular dose of ceftriaxone changes nasopharyngeal bacterial flora in children with acute otitis media. Acta Paediatr 2000;89:1316-21. 1.20 Puhakka T, Heikkinen T, Mäkelä MJ, Alanen A, Kallio T, Korsoff L, Suonpää J, Ruuskanen O. Validity of ultrasonography in diagnosis of acute maxillary sinusitis. Arch Otolaryngol Head Neck Surg 2000;126:1482-6. 1.21 Heikkinen T. Role of viruses in the pathogenesis of acute otitis media. Pediatr Infect Dis J 2000;19:S17-23. 1.22 Heikkinen T, Chonmaitree T. Increasing importance of viruses in acute otitis media. Ann Med 2000;32:157-63. 1.23 Heikkinen T, Chonmaitree T. Viral-bacterial synergy in otitis media: implications for management. Curr Infect Dis Rep 2000;2:154-9. 1.24 Chonmaitree T, Heikkinen T. Viruses and acute otitis media. Pediatr Infect Dis J 2000;19:1005-7. 1.25 Heikkinen T. The role of respiratory viruses in otitis media. Vaccine 2000;19(suppl.1):S51-5. 1.26 Heikkinen T, Salmi AA, Ruuskanen O. Comparative study of nasopharyngeal aspirate and nasal swab specimens for detection of influenza. BMJ 2001;322:138.

3 1.27 Peltola V, Heikkinen T, Ruuskanen O. Clinical courses of croup caused by influenza and parainfluenza viruses. Pediatr Infect Dis J 2002;21:76-8. 1.28 Heikkinen T, Marttila J, Salmi AA, Ruuskanen O. Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses. J Clin Microbiol 2002;40:4337-9. 1.29 Jartti T, Vanto T, Heikkinen T, Ruuskanen O. Systemic glucocorticoids in childhood expiratory wheezing: relation between age and viral etiology with efficacy. Pediatr Infect Dis J 2002;21:873-8. 1.30 Ogra PL, Barenkamp SJ, DeMaria TF, Bakaletz LO, Chonmaitree T, Heikkinen T, Hurst DS, Kawauchi H, Kurono Y, Patel JA, Sih TM, Stenfors L-E, Suzuki M. Recent advances in otitis media. 6. Microbiology and immunology. Ann Otol Rhinol Laryngol 2002;111(Suppl 188):62-81. 1.31 Giebink GS, Bakaletz LO, Barenkamp SJ, Eskola J, Green B, Gu X-X, Harada T, Heikkinen T, Karma P, Klein JO, Kurono Y, Mogi G, Murphy TF, Ogra PL, Patel JA, Suzuki M, Yamanaka N. Recent advances in otitis media. 7. Vaccine. Ann Otol Rhinol Laryngol 2002:111(Suppl 188):82-94. 1.32 Heikkinen T, Järvinen A. The common cold. Lancet 2003;361:51-9. 1.33 Heikkinen T, Chonmaitree T. Importance of respiratory viruses in acute otitis media. Clin Microbiol Rev 2003;16:230-41. 1.34 McCormick DP, Saeed K, Uchida T, Baldwin CD, Deskin R, Lett-Brown MA, Heikkinen T, Chonmaitree T. Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment. Int J Pediatr Otorhinolaryngol 2003;67:221-30. 1.35 Ruohola A, Heikkinen T, Meurman O, Puhakka T, Lindblad N, Ruuskanen O. Antibiotic treatment of acute otorrhea through tympanostomy tube: randomized double-blind placebo-controlled study with daily follow-up. Pediatrics 2003;111:1061-7. 1.36 Chonmaitree T, Saeed K, Uchida T, Heikkinen T, Baldwin CD, Freeman DH Jr, McCormick DP. A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media. J Pediatr 2003;143:377-85. 1.37 Heikkinen T, Ziegler T, Peltola V, Lehtinen P, Toikka P, Lintu M, Jartti T, Juvén T, Kataja J, Pulkkinen J, Kainulainen L, Puhakka T, Routi T. Incidence of influenza in Finnish children. Pediatr Infect Dis J 2003;22:S204-6. 1.38 Heikkinen T, Silvennoinen H, Peltola V, Ziegler T, Vainionpää R, Vuorinen T, Kainulainen L, Puhakka T, Jartti T, Toikka P, Lehtinen P, Routi T, Juvén T. Burden of influenza in children in the community. J Infect Dis 2004;190:1369-73.

4 1.39 Heikkinen T, Valkonen H, Lehtonen L, Vainionpää R, Ruuskanen O. Hospital admission of high risk infants for respiratory syncytial virus infection: implications for palivizumab prophylaxis. Arch Dis Child Fetal Neonatal Ed 2005;90:F64-8. 1.40 Peltola V, Reunanen T, Ziegler T, Silvennoinen H, Heikkinen T. Accuracy of clinical diagnosis of influenza in outpatient children. Clin Infect Dis 2005;41:1198-200. 1.41 Barenkamp SJ, Ogra PL, Bakaletz LO, Chonmaitree T, Heikkinen T, Hurst DS, Kawauchi H, Kurono Y, Leiberman A, Murphy TF, Patel JA, Sih TM, St Geme III JW, Stenfors LE. Recent advances in otitis media: Report of the eighth research conference. 5. Microbiology and immunology. Ann Otol Rhinol Laryngol 2005;114(Suppl 194):60-85. 1.42 Giebink GS, Bakaletz LO, Barenkamp SJ, Green B, Gu XX, Heikkinen T, Hotomi M, Karma P, Kurono Y, Kyd JM, Murphy TF, Ogra PL, Patel JA, Pelton SI. Recent advances in otitis media: Report of the eighth research conference. 6. Vaccine. Ann Otol Rhinol Laryngol 2005;114(Suppl 194):86-103. 1.43 Ruohola A, Meurman O, Nikkari S, Skottman T, Salmi A, Waris M, Österback R, Eerola E, Allander T, Niesters H, Heikkinen T, Ruuskanen O. Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses. Clin Infect Dis 2006;43:1417-22. 1.44 Salo H, Kilpi T, Sintonen H, Linna M, Peltola V, Heikkinen T. Cost-effectiveness of influenza vaccination of healthy children. Vaccine 2006;24:4934-41. 1.45 Heikkinen T, Booy R, Campins M, Finn A, Olcén P, Peltola H, Rodrigo C, Schmitt H-J, Schumacher F, Teo S, Weil-Olivier C. Should healthy children be vaccinated against influenza? A consensus report of the Summits of Independent European Vaccination Experts. Eur J Pediatr 2006;165:223-8. 1.46 Heikkinen T. Influenza in children. Acta Paediatr 2006;95:778-84. 1.47 Peltola V, Svedström E, Waris M, Heikkinen T, Ruuskanen O. Pulmonary abscess of viral-bacterial etiology in a neonate. Eur J Pediatr 2007;166:1301-2. 1.48 Ruohola A, Meurman O, Nikkari S, Skottman T, Heikkinen T, Ruuskanen O. The dynamics of bacteria in the middle ear during the course of acute otitis media with tympanostomy tube otorrhea. Pediatr Infect Dis J 2007;26:892-6. 1.49 Waris ME, Heikkinen T, Österback R, Jartti T, Ruuskanen O. Nasal swabs for detection of respiratory syncytial virus RNA. Arch Dis Child 2007;92:1046-7. 1.50 Schmitt HJ, Booy R, Aston R, Van-Damme P, Schumacher RF, Campins M, Rodrigo C, Heikkinen T, Weil-Olivier C, Finn A, Olcén P, Fedson D, Peltola H. How to optimise the coverage rate of infant and adult immunisation in Europe. BMC Medicine 2007;5:11.

5 1.51 Heikkinen T, Österback R, Peltola V, Jartti T, Vainionpää R. Human metapneumovirus infections in children. Emerg Infect Dis 2008;14:101-6. 1.52 Sengupta N, Booy R, Schmitt HJ, Peltola H, Van-Damme P, Schumacher RF, Campins M, Rodrigo C, Heikkinen T, Seward J, Jumaan A, Finn A, Olcén P, Thiry N, Weil-Olivier C, Breuer J. Varicella vaccination in Europe: are we ready for a universal childhood programme? Eur J Pediatr 2008;167:47-55. 1.53 Valkonen H, Waris M, Ruohola A, Ruuskanen O, Heikkinen T. Recurrent wheezing after respiratory syncytial virus or non-respiratory syncytial virus bronchiolitis in infancy: a 3-year follow-up. Allergy 2009;64:1359-65. 1.54 Silvennoinen H, Peltola V, Lehtinen P, Vainionpää R, Heikkinen T. Clinical presentation of influenza in unselected children treated as outpatients. Pediatr Infect Dis J 2009;28:372-5. 1.55 Ruohola A, Waris M, Allander T, Ziegler T, Heikkinen T, Ruuskanen O. Viral etiology of common cold in children, Finland. Emerg Infect Dis 2009;15:344-6. 1.56 Paget WJ, Balderston C, Casas I, Donker G, Edelman L, Fleming D, Larrauri A, Meijer A, Puzelli S, Rizzo C, Simonsen L, and all EPIA collaborators (Bella A, Pérez-Breña P, Lopez Cuadrado T, de Mateo S, Donatelli I, Elliot A, Glisman S, Heikkinen T, Ortiz de Lejarazu Leonardo R, Mazick A, McMenamin J, Molbak K, Nielsen L, Pnaiser R, Pregliasco F, Reynolds A, Smith D, Pumarola Suñé T, van der Sande M, Vega Alonso T, Vesikari T, Watson J, Weil-Olivier C, Zambon M, Ziegler T). Assessing the burden of paediatric influenza in Europe: the European Paediatric Influenza Analysis (EPIA) project. Eur J Pediatr 2010;169:997-1008. 1.57 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Vahlberg T, Ziegler T, Ikonen N, Puhakka T, Heikkinen T. Early oseltamivir treatment of influenza in children 1-3 years of age: a randomized controlled trial. Clin Infect Dis 2010;51:887-94. 1.58 Block SL, Heikkinen T, Toback SL, Zheng W, Ambrose CS. The efficacy of live attenuated influenza vaccine against influenza-associated acute otitis media in children. Pediatr Infect Dis J 2011;30:203-7. 1.59 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Heikkinen T. Feasibility of diagnosing influenza within 24 hours of symptom onset in children 1-3 years of age. Eur J Clin Microbiol Infect Dis 2011;30:387-92. 1.60 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Ziegler T, Heikkinen T. Effectiveness of inactivated influenza vaccine in children aged 9 months to 3 years: an observational cohort study. Lancet Infect Dis 2011;11:23-9. 1.61 Silvennoinen H, Peltola V, Vainionpää R, Ruuskanen O, Heikkinen T. Incidence of influenza-related hospitalizations in different age groups of children in Finland: a 16- year study. Pediatr Infect Dis J 2011;30:e24-e28

6 1.62 Peltola V, Heikkinen T, Ruuskanen O, Jartti T, Hovi T, Kilpi T, Vainionpää R. Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children Pediatr Infect Dis J 2011;30:456-61. 1.63 Huttunen R, Heikkinen T, Syrjänen J. Smoking and the outcome of infection. J Intern Med 2011;269:258-69. 1.64 Heikkinen T, Heinonen S. Effectiveness and safety of influenza vaccination in children: European perspective. Vaccine 2011;29:7529-34. 1.65 Fraaij PLA, Heikkinen T. Seasonal influenza: the burden of disease in children. Vaccine 2011;29:7524-8. 1.66 Silvennoinen H, Peltola V, Vainionpää R, Ruuskanen O, Heikkinen T. Admission diagnoses of children 0-16 years of age hospitalized with influenza. Eur J Clin Microbiol Infect Dis 2012;31:225-31. 1.67 Heinonen S, Peltola V, Silvennoinen H, Vahlberg T, Heikkinen T. Signs and symptoms predicting influenza in children: a matched case-control analysis of prospectively collected clinical data. Eur J Clin Microbiol Infect Dis 2012;31:1569-74. 1.68 Antonova EN, Rycroft CE, Ambrose CS, Heikkinen T, Principi N. Burden of paediatric influenza in Western Europe: a systematic review. BMC Public Health 2012;12:968. 1.69 Heikkinen T, Young J, van Beek E, Franke H, Verstraeten T, Weil JG, Della Cioppa G. Safety of MF59-adjuvanted A/H1N1 influenza vaccine in pregnancy: a comparative cohort study. Am J Obstet Gynecol 2012;207:177.e1-8. 1.70 Heikkinen T, Block SL, Toback SL, Wu X, Ambrose CS. Effectiveness of intranasal live attenuated influenza vaccine against all-cause acute otitis media in children. Pediatr Infect Dis J 2013;32:669-74. 1.71 Ivaska L, Niemelä J, Heikkinen T, Vuorinen T, Peltola V. Identification of respiratory viruses with a novel point-of-care multianalyte antigen detection test in children with acute respiratory tract infection. J Clin Virol 2013;57:136-40. 1.72 Murphy TF, Chonmaitree T, Barenkamp S, Kyd J, Nokso-Koivisto J, Patel JA, Heikkinen T, Yamanaka N, Ogra P, Swords WE, Sih T, Pettigrew MM. Microbiology and immunology panel. Otolaryngol Head Neck Surg 2013;148(4 suppl):e64-89. 1.73 Heikkinen T, Tsolia M, Finn A. Vaccination of healthy children against seasonal influenza: a European perspective. Pediatr Infect Dis J 2013;32:881-8. 1.74 Puhakka T, Pulkkinen J, Silvennoinen H, Heikkinen T. Comparison of spectral gradient acoustic reflectometry and tympanometry for detection of middle ear effusion in children. Pediatr Infect Dis J 2014;33:e183-6.

7 1.75 Heikkinen T, Ikonen N, Ziegler T. Impact of influenza B lineage-level mismatch between trivalent seasonal influenza vaccines and circulating viruses, 1999-2012. Clin Infect Dis 2014;59:1519-24. 1.76 Bont L, Baraldi E, Fauroux B, Greenough A, Heikkinen T, Manzoni P, Martinón-Torres F, Nair H, Papadopoulos NG. RSV- still more questions than answers. Pediatr Infect Dis J 2014;33:1177-9. 1.77 Heikkinen T, Valkonen H, Waris M, Ruuskanen O. Transmission of respiratory syncytial virus infection within families. Open Forum Infect Dis 2015;2:ofu118. 1.78 Mazur NI, Martinón-Torres F, Baraldi E, Fauroux B, Greenough A, Heikkinen T, Manzoni P, Mejias A, Nair H, Papadopoulos NG, Polack FP, Ramilo O, Sharland M, Stein R, Madhi SA, Bont L, Respiratory Syncytial Virus Network (ReSViNET). Lower respiratory tract infection caused by respiratory syncytial virus: current management and new therapeutics. Lancet Respir Med 2015;3:888-900. 1.79 Silvennoinen H, Huusko T, Vuorinen T, Heikkinen T. Comparative burden of influenza A/H1N1, A/H3N2 and B infections in children treated as outpatients. Pediatr Infect Dis J 2015;34:1081-5. 1.80 Caspard H, Heikkinen T, Belshe RB, Ambrose CS. A systematic review of the efficacy of live attenuated influenza vaccine upon revaccination of children. Hum Vaccin Immunother 2016;12:1721-7. 1.81 Heikkinen T, Silvennoinen H, Heinonen S, Vuorinen T. Clinical and socioeconomic impact of moderate-to-severe versus mild influenza in children. Eur J Clin Microbiol Infect Dis 2016;35:1107-13. 1.82 Heikkinen T. Respiratory viruses and children. J Infect 2016;72:S29-33. 1.83 Nagy L, Heikkinen T, Sackeyfio A, Pitman R. The clinical impact and cost effectiveness of quadrivalent versus trivalent influenza vaccination in Finland. PharmacoEconomics 2016;34:939-51. 1.84 Luoto R, Jartti T, Ruuskanen O, Waris M, Lehtonen L, Heikkinen T. Review of the clinical significance of respiratory virus infections in newborn infants. Acta Paediatr 2016;105:1132-9. 1.85 Nair H, Ramilo O, Eichler I, Pelfrene E, Mejias A, Polack FP, Pouwels KB, Langley JM, Nunes M, van der Maas N, Kragten-Tabatabaie L, Baraldi E, Heikkinen T, Fauroux B, Sharland M, Park C, Manzoni P, Papadopoulos NG, Martinón-Torres F, Stein R, Bont L, in collaboration with Respiratory Syncytial Virus Network (ReSViNET). Meeting report: Harmonization of RSV therapeutics: from design to performance. J Global Health 2016;6:010205.

8 1.86 Heikkinen T, Ojala E, Waris M. Clinical and socioeconomic burden of respiratory syncytial virus infection in children. J Infect Dis 2017;215:17-23. 1.87 Barenkamp SJ, Chonmaitree T, Hakansson AP, Heikkinen T, King S, Nokso-Koivisto J, Novotny LA, Patel JA, Pettigrew M, Swords WE. Report of the Microbiology Panel. (submitted) 1.88 Shaw I, Ciblak M, Gabriel G, Guthmann JP, Heikkinen T, Heinz F, Kunze M, Kunze U, Kyncl J, Lina B, Monto A, Openshaw P, Osterhaus A, Prymula R, Tashiro M, van Essen T, Vanlangendonck C, Van Ranst M, Van-Tam J, Wagner R. Pandemic influenza preparedness: key findings from a European survey. (submitted) 2. ARTICLES IN DOMESTIC PEER-REVIEWED JOURNALS 2.1 Heikkinen T, Ruuskanen O, Jero J, Virolainen E. Vuotavan putkikorvan hoito. Duodecim 1997;113:336-9. 2.2 Heikkinen T, Ruohola A, Ruuskanen O, Waris M, Uhari M, Hammarström L. Nenään suihkutettava immunoglobuliini lasten hengitystieinfektioiden ehkäisyssä. Duodecim 1998;114:1713-8. 2.3 Peltola V, Heikkinen T, Saxén H, Ruuskanen O. Lasten influenssa A-infektio. Suom Lääkäril 1999;54:453-7. 2.4 Heikkinen T, Ruuskanen O. Lapsen infektiokierre. Duodecim 2001;117:731-6. 2.5 Nuorti P, Nohynek H, Heikkinen T, Salo H, Hulkko T, Koivula I, Honkanen P, Kilpi T. Lasten pneumokokkitautien ehkäisy rokotuksin. Suom Lääkäril 2002;57:3003-8. 2.6 Heikkinen T. Riittävätkö akuutin otiitin oireet ja tärykalvolöydökset oikeaan diagnoosiin pääsemiseen? Suom Lääkäril 2002;57:4221-3. 2.7 Heikkinen T. Hengitysteiden virusinfektioiden spesifinen lääkehoito. Suom Lääkäril 2003;58:3531-5. 2.8 Heikkinen T. Mitä uutta flunssasta? (editorial). Duodecim 2003;119:1705-7. 2.9 Peltola V, Heikkinen T. Miten hengitysteiden virusinfektio johtaa bakteerikomplikaatioihin? Duodecim 2006;122:2094-100. 2.10 Heikkinen T. Influenssan lapsille aiheuttama tautitaakka (editorial). Duodecim 2006;122:251-2. 2.11 Heikkinen T. Lasten äkillisen välikorvatulehduksen hoito. Suom Lääkäril 2006;61:2124-5.

9 2.12 Heikkinen T. Milloin influenssaa kannattaa hoitaa? (editorial). Duodecim 2007;123:125-6. 2.13 Heikkinen T. Lasten äkillisen välikorvatulehduksen hoito antibiootilla vai ilman? (editorial). Suom Lääkäril 2008;63:1371-2. 2.14 Heikkinen T. Lasten influenssan hoito oseltamiviirilla on hyödyllistä (editorial). Duodecim 2010;126:2461-2. 2.15 Heikkinen T. Onko antibiootista sittenkin hyötyä lasten äkillisen välikorvatulehduksen hoidossa? (editorial). Suom Lääkäril 2011;66:229-30. 3. INTERNATIONAL TEXTBOOKS AND TEXTBOOK CHAPTERS Textbook chapters 3.1 Heikkinen T. Viral vaccines for recurrent acute otitis media. In: Alper CM, Bluestone CD, Casselbrant ML, Dohar JE, Mandel EM, eds. Advanced Therapy of Otitis Media. BC Decker, Ontario, 2004:130-3. 3.2 Heikkinen T. Post-tympanostomy tube otorrhea. In: Alper CM, Bluestone CD, Casselbrant ML, Dohar JE, Mandel EM, eds. Advanced Therapy of Otitis Media. BC Decker, Ontario, 2004:238-41. 3.3 Heikkinen T. Influenza. In: Kunnamo I, ed. Evidence-Based Medicine Guidelines. Chichester, UK: John Wiley & Sons Ltd, 2005:14-6. 3.4 Heikkinen T. Prevention of otitis media in children. In: Kunnamo I, ed. Evidence-Based Medicine Guidelines. Chichester, UK: John Wiley & Sons Ltd, 2005:957-8. 3.5 Heikkinen T. Otitis media in children: definition, epidemiology and diagnosis. In: Kunnamo I, ed. Evidence-Based Medicine Guidelines. Chichester, UK: John Wiley & Sons Ltd, 2005:958-61. 3.6 Heikkinen T. Treatment and follow-up of acute otitis media in children. In: Kunnamo I, ed. Evidence-Based Medicine Guidelines. Chichester, UK: John Wiley & Sons Ltd, 2005:961-3. 3.7 Heikkinen T. Otorrhoea in children with tympanostomy tubes. In: Kunnamo I, ed. Evidence-Based Medicine Guidelines. Chichester, UK: John Wiley & Sons Ltd, 2005:966-7. 3.8 Heikkinen T, Ruuskanen O. Upper respiratory tract infection. In: Laurent GJ, Shapiro SD, eds. Encyclopedia of Respiratory Medicine. Elsevier, 2006:385-8.

10 3.9 Heikkinen T. Influenza and parainfluenza. In: Sharland M, ed. Manual of Childhood Infections; The Blue Book (third edition). Oxford University Press, 2011:595-9. (Fourth edition: Oxford University Press, 2016:628-32). 4. DOMESTIC TEXTBOOKS AND TEXTBOOK CHAPTERS Textbooks 4.1 Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M (editors). Mikrobiologia. Helsinki: Duodecim, 2010 (736 pages). 4.2 Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M (editors). Immunologia. Helsinki: Duodecim, 2011 (423 pages). 4.3 Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M (editors). Infektiosairaudet. Helsinki: Duodecim, 2011 (869 pages). Textbook chapters 4.4 Heikkinen T. Influenssa. In: Ruuskanen O, Peltola H, Vesikari T, eds. Lasten infektiosairaudet. 2nd edition. Turku: Pfizer, 2000:104-9. 4.5 Heikkinen T. Lapsen välikorvatulehduksen ehkäisy. In: Kunnamo I, et al., eds. Lääkärin käsikirja. Kustannus Oy Duodecim, 6th edition. 2002:990-1. (Kunnamo I, ed. Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006:1015-6.) 4.6 Heikkinen T. Lapsen välikorvatulehdus: määritelmä, epidemiologia ja diagnostiikka. In: Kunnamo I, et al., eds. Lääkärin käsikirja. Kustannus Oy Duodecim, 6th edition. 2002:991-3. (Kunnamo I, ed. Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006:1009-10.) 4.7 Heikkinen T. Lapsen välikorvatulehduksen hoito ja seuranta. In: Kunnamo I, et al., eds. Lääkärin käsikirja. Kustannus Oy Duodecim, 6th edition. 2002:993-5. (Kunnamo I, ed. Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006:1012-3.) 4.8 Heikkinen T. Vuotava putkikorva. In: Kunnamo I, et al., eds. Lääkärin käsikirja. Kustannus Oy Duodecim, 6th edition. 2002:997-8. (Kunnamo I, ed. Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006:1014-5.) 4.9 Nuorti P, Heikkinen T, Honkanen P, Hulkko T, Kilpi T, Koivula I, Nohynek H, Salo H. Pneumokokkirokotteet. In: Nohynek H, Pekkanen E, Hulkko T, Joensuu J, Kilpi T, eds. Rokottajan käsikirja ja käytännön kysymyksiä. Kustannus Oy Duodecim ja Kansanterveyslaitos, 2003:150-62.

11 4.10 Ruuskanen O, Heikkinen T. Ylähengitystieinfektiot ja otiitti. In: Huovinen P, Meri S, Peltola H, Vaara M, Vaheri A, Valtonen V, eds. Mikrobiologia ja infektiosairaudet, kirja II. Kustannus Oy Duodecim, 1st edition. 2003:353-73. 4.11 Heikkinen T. Influenssa. In: Kunnamo I, ed. Lääkärin käsikirja 2006. Helsinki: Kustannus Oy Duodecim, 2006:20-2. 4.12 Heikkinen T. Influenssa. In: Ruuskanen O, Peltola H, Vesikari T, eds. Lasten infektiosairaudet. Tampereen yliopiston rokotetutkimuskeskus, 2007:153-60. 4.13 Heikkinen T, Renko M. Otiitti. In: Ruuskanen O, Peltola H, Vesikari T, eds. Lasten infektiosairaudet. Tampereen yliopiston rokotetutkimuskeskus, 2007:161-71. 4.14 Ziegler T, Heikkinen T. Influenssavirukset. In: Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M, eds. Mikrobiologia. Duodecim, 2010:470-86. 4.15 Ruuskanen O, Heikkinen T. Ylähengitystieinfektiot ja otiitti. In: Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M, eds. Infektiosairaudet. Duodecim, 2011:418-40. 4.16 Heikkinen T, Leino T, Mertsola J, Peltola H, Renko M, Salo E. Suomessa yleiset rokotteet. In: Hedman K, Heikkinen T, Huovinen P, Järvinen A, Meri S, Vaara M, eds. Infektiosairaudet. Duodecim, 2011:782-823. 5. OTHER SCIENTIFIC PUBLICATIONS Academic dissertation 5.1 Heikkinen T. Development and prevention of acute otitis media in children. Annales Universitatis Turkuensis D 158. 1994;1-129. Editorials and commentaries in international peer-reviewed journals 5.2 Heikkinen T. Influenza in children: The unrecognized burden. Introduction. Pediatr Infect Dis J 2003;22:S203. 5.3 Heikkinen T, Peltola V. Influenza vaccination of children. Lancet Infect Dis 2009;9:720-1. 5.4 Peltola V, Ruuskanen O, Heikkinen T. Targeting influenza vaccinations of children. CMAJ 2011;183:1464-5. Correspondence in international peer-reviewed journals 5.5 Heikkinen T, Ruuskanen O. Influenza vaccination and acute otitis media in children reply. Am J Dis Child 1992;146:1019.

12 5.6 Heikkinen T, Ruuskanen O. Signs and symptoms predicting acute otitis media in reply. Arch Pediatr Adolsec Med 1995;149:1285 5.7 Heikkinen T, Chonmaitree T, Thint M. Respiratory viruses and acute otitis media reply. N Engl J Med 1999;340:2002. 5.8 Heikkinen T, Järvinen A. Comments on the common cold authors reply. Lancet 2003;361:782. 5.9 Heikkinen T, Ruuskanen O. Effectiveness of influenza vaccine to prevent acute otitis media (letter). JAMA 2004;291:692-3. 5.10 Heikkinen T, Ruuskanen O. Influenza vaccines in healthy children (letter). Lancet 2005;365:2086-7. 5.11 Heikkinen T, Heinonen S. Influenza vaccination in young children authors reply. Lancet Infect Dis 2011;11:657-8. 5.12 Heikkinen T, Heinonen S. Influenza vaccine in young children (letter). N Engl J Med 2012;366:383-4. Editor of supplements in international peer-reviewed journals 5.13 Heikkinen T (editor). Influenza in children: the unrecognized burden. Pediatr Infect Dis J (Supplement) 2003;22:S203-S235. Articles in international proceeding books and Continuous Medical Education publications 5.14 Heikkinen T, Waris M, Ruuskanen O. Efficacy of influenza vaccination in reducing otitis media in children. In: Hannoun C, Kendal AP, Klenk HD, Ruben FL, eds. Options for the control of influenza II. Amsterdam: Elsevier, 1993:431-4. 5.15 Heikkinen T. Pathogenesis of respiratory viral infections in acute otitis media. In: Edwards KM, Klein J, Paradise JL, Neuzil KM, Heikkinen T, Clements DA (eds). Respiratory viral vaccines for prevention of otitis media. Colorado, USA: Postgraduate Institute for Medicine, 2001;6-7. 5.16 Chonmaitree T, Saeed K, McCormick DP, Uchida T, Heikkinen T, Baldwin CD. Histamine concentrations in the middle ear fluid of children with acute otitis media before and after antihistamine treatment. In: Lim DJ, Bluestone CD, Casselbrant M, Bakaletz LO, Giebink GS, Klein JO, DeMaria TF, Ogra PL, eds. Recent advances in otitis media with effusion. BC Decker Inc.; Ontario, Canada, 2002:377-8. 5.17 Saeed K, Heikkinen T, McCormick DP, Baldwin CD, Chonmaitree T. Does nasopharyngeal bacterial flora change after a dose of ceftriaxone? In: Lim DJ, Bluestone CD, Casselbrant M, Bakaletz LO, Giebink GS, Klein JO, DeMaria TF, Ogra PL,

13 eds. Recent advances in otitis media with effusion. BC Decker Inc.; Ontario, Canada, 2002:617-8. 5.18 Heikkinen T, Silvennoinen H, Reunanen T, Ziegler T, Vainionpää R. Illness symptoms and absences due to influenza in different age groups of children. In: Kawaoka Y, ed. Options for the control of influenza V. Elsevier, Amsterdam, 2004:101-4. 5.19 Heikkinen T, Silvennoinen H, Reunanen T, Ziegler T, for the Study Group. Incidence of acute otitis media during different viral infections in children younger than 3 years. In: Lim DJ, Bluestone CD, Casselbrant M, eds. Recent Advances in Otitis Media: Proceedings of the Eighth International Symposium, 2003. BC Decker Inc, Ontario, 2005:233-5. 5.20 Chonmaitree T, Saeed K, Uchida T, Heikkinen T, Baldwin CD, Freeman DH Jr, McCormick DP. Effect of antihistamine or corticosteroid treatment on acute otitis media: randomized controlled trial. In: Lim DJ, Bluestone CD, Casselbrant M, eds. Recent Advances in Otitis Media: Proceedings of the Eighth International Symposium, 2003. BC Decker Inc, Ontario, 2005:201-5. 5.21 Heikkinen T. Influenza in children: strategies for prevention. In: Vaccinating Schoolchildren: Next Step Forward in the Battle Against Influenza? Haymarket Medical Education, New Jersey, USA. 2009:4-6. 5.22 Barenkamp SJ, Chonmaitree T, Ogra PL, Bakaletz LO, Bernstein J, Heikkinen T, Hurst DS, Kawauchi H, Patel JA, Sih TM, Webster P, Yamanaka N. Microbiology and immunology. In: Lim DJ, ed. Recent Advances in Otitis Media: Report of the Ninth Research Conference, 2007. House Ear Institute, 2010:64-93 (ISBN: 0-9776204-1-7) 5.23 Bakaletz LO, Pelton SI, Klein JO, Barenkamp SJ, Denoel P, Green BA, Gu XX, Heikkinen T, Hotomi M, Karma P, Kurono Y, Kyd JM, Murphy TF, Ogra PL, Patel JA, Pettigrew M, Veenhoven R, Yamanaka N. Vaccine. In: Lim DJ, ed. Recent Advances in Otitis Media: Report of the Ninth Research Conference, 2007. House Ear Institute, 2010:94-119 (ISBN: 0-9776204-1-7) 5.24 Heikkinen T. The role of viruses in otitis media. In: Lim DJ, Bluestone CD, Casselbrant M, eds. Recent Advances in Otitis Media: Proceedings of the Ninth International Symposium, 2007. House Ear Institute; 50-53. Available online: www.hei.org/otitis2007/. Web-based medical education materials 5.25 McCormick DP, Chonmaitree T, Heikkinen T, Friedman N, Rosenfeld RM. Acute Otitis Media. 2000 (last modified 29 November 2012). http://www.utmb.edu/pedi_ed/aom-otitis/default.htm

14 5.26 Low DE, Heikkinen T, Ison MG, Wise RA. Optimizing the Use of Antivirals in High-Risk Patients With Seasonal Influenza (CME activity). http://www.medscape.org/viewprogram/31816 (available 4 Nov 2010). 5.27 Richtmann R, Heikkinen T, Sáfadi M, Tan T. Global update on varicella: Protecting against an old enemy. Medscape Education. http://www.medscape.org/viewarticle/855570 (CME released 22 Jan 2016). Other international scientific articles 5.28 Heikkinen T. The burden of influenza in children. Influenza Bulletin 2001;(No.13):6. 5.29 Heikkinen T. The burden of influenza on children: study update. Influenza Bulletin 2001;(No.14):6-7. Domestic treatment guidelines 5.30 Puhakka H, Hagman E, Heikkinen T, Huovinen P, Jero J, Karma P, Mäkelä M, Ruuskanen O, Sairanen S. Äkillisen välikorvatulehduksen hoitosuositus. Duodecim 1999;115:2155-61. 5.31 Suomen Lastenlääkäriyhdistys ry:n, Suomen Otolaryngologiyhdistys ry:n ja Suomen Yleislääketieteen yhdistys ry:n asettama työryhmä (Heikkinen T, et al). Äkillinen välikorvatulehdus: Käypä hoito suositus [online]. Helsinki: Suomalainen Lääkäriseura Duodecim, 2004 [päivitetty 15.6.2004]. Available online: www.kaypahoito.fi. 5.32 Äkillinen välikorvatulehdus (online). Käypä hoito suositus. Suomalaisen Lääkäriseuran Duodecimin, Suomen Lastenlääkäriyhdistys ry:n, Suomen Otolaryngologiyhdistys ry:n ja Suomen Yleislääketieteen yhdistys ry:n asettama työryhmä (Heikkinen T, Huovinen P, Jero J, Pitkäranta A, Renko M, Sumanen M, Heikkilä E). Helsinki: Suomalainen Lääkäriseura Duodecim, 2010. Available online: www.kaypahoito.fi. Other domestic scientific articles 5.33 Heikkinen T. Miten hoidan lasten hengitystieinfektioita? Käytännön lääkäri 2000;44:81-6. 5.34 Kalliomäki M, Peltola V, Heikkinen T. Kolmivuotiaan lyhytaikainen tajunnanhäiriö. Duodecim 2000;116:2785-7. 5.35 Vuento R, Möttönen T, Heikkinen T. Kevättalven infektiot. Erikoislääkäri 2004;14:49-54. 5.36 Heikkinen T, Huovinen P, Jero J, Karma P, Mäkelä M, Puhakka H, Renko M, Sumanen M. Äkillinen välikorvatulehdus. Duodecim 2004;120:2129-30. 5.37 Heikkinen T. Influenssa ja sen lääkehoito. Erikoislääkäri 2004;14:227-30.

15 5.38 Heikkinen T. Influenssa. Duodecim 2007;123:277-8. 5.39 Heikkinen T, Salo H, Kilpi T. Suositus lasten influenssarokotuksista ei sittenkään niin hataralla pohjalla. Duodecim 2007;123:2350-1. 5.40 Heikkinen T, Huovinen P, Jero J, Pitkäranta A, Renko M, Sumanen M, Heikkilä E. Äkillinen välikorvatulehdus. Duodecim 2010;126:573-4. 5.41 Lehtola L, Broas M, Hautala T, Heikkinen J, Heikkinen T, Huttunen R, Kantele A, Mikkola J, Nieminen T, Pakarinen L, Ruotsalainen E. Ei mikrobilääkkeiden määräämisoikeutta hoitajille. Suom Lääkäril 2010;65:264. Scientific news reports for pediatricians 5.42 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 1999;115:413. 5.43 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 1999;115:1111. 5.44 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 1999;115:1798. 5.45 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 1999;115:2484. 5.46 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2000;116:645. 5.47 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2000;116:1403. 5.48 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2000;116:2005. 5.49 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2000;116:2794. 5.50 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2001;117:602. 5.51 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2001;117:1271. 5.52 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2001;117:1674. 5.53 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2001;117:2559. 5.54 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2002;118:635. 5.55 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2002;118:1287. 5.56 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2002;118:1903. 5.57 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2002;118:2509.

16 5.58 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2003;119:469. 5.59 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2003;119:1172. 5.60 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2003;119:1792. 5.61 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2003;119:2469. 5.62 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2004;120:730. 5.63 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2004;120:1509. 5.64 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2004;120:2166. 5.65 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2004;120:2886. 5.66 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2005;121:727. 5.67 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2005;121:1293. 5.68 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2005;121:1943. 5.69 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2005;121:2652. 5.70 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2006;122:645. 5.71 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2006;122:1430. 5.72 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2006;122:2209. 5.73 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2006;122:2969. 5.74 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2007;123:649. 5.75 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2007;123:1387. 5.76 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2007;123:2945. 5.77 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2008;124:615. 5.78 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2008;124:1353. 5.79 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2008;124:2073. 5.80 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2008;124:2797. 5.81 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2009;125:605.

17 5.82 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2009;125:1251. 5.83 Heikkinen T. Erikoislääkärin uutiset: Pediatria. Duodecim 2009;125:1947. 6. ABSTRACTS 6.1 Heikkinen T, Ruuskanen O, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media. Conference on the Eustachian Tube and Middle Ear Diseases. Geneva, Switzerland, 26-29.10.1989. 6.2 Heikkinen T, Ruuskanen O, Waris M, Ziegler T, Arola M, Halonen P. Influenza vaccination in the prevention of acute otitis media. 8th Annual Meeting of the European Society for Paediatric Infectious Diseases. Göteborg, Sweden, 16-18.5.1990. 6.3 Heikkinen T, Waris M, Ruuskanen O. Development of acute otitis media during upper respiratory tract infection. 9th Annual Meeting of the European Society for Paediatric Infectious Diseases. St. Feliu de Guixols, Spain, 18-19.4.1991. 6.4 Heikkinen T, Waris M, Ruuskanen O. Development of acute otitis media during upper respiratory tract infection. 5th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 20-24.5.1991. 6.5 Heikkinen T, Waris M, Ruuskanen O. Efficacy of influenza vaccination in reducing otitis media in children. Options for the Control of Influenza II. Courchevel, France, 26.9-2.10.1992. 6.6 Heikkinen T, Ruohola A, Ruuskanen O, Uhari M, Hammarström L. Intranasal immunoglobulin prevents upper respiratory tract infections. 15th Annual Meeting of the European Society for Paediatric Infectious Diseases. Paris, France, 21-23.5.1997. 6.7 Saeed KA, Heikkinen T, McCormick DP, Baldwin C, Chonmaitree T. A single intramuscular dose of ceftriaxone changes nasopharyngeal bacterial flora in children with acute otitis media (AOM). Pediatric Academic Societies 1998 Annual Meeting. New Orleans, USA, 1-5.5.1998. 6.8 Thint M, Heikkinen T, Chonmaitree T. Middle ear (ME) invasion by different respiratory viruses during acute otitis media (AOM). Pediatric Academic Societies 1998 Annual Meeting. New Orleans, USA, 1-5.5.1998. 6.9 Ruohola A, Heikkinen T, Puhakka T, Saarinen T, Ruuskanen O. Intranasally administered fluticasone propionate for prevention of acute otitis media in children. 38th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, USA, 24-27.9.1998.

18 6.10 Ruohola A, Heikkinen T, Waris M, Puhakka T, Juven T, Ruuskanen O. Intranasally administered fluticasone propionate for prevention of acute otitis media during common cold. 7th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 1-5.6.1999. 6.11 Chonmaitree T, Saeed K, McCormick DP, Uchida T, Heikkinen T, Baldwin CD. Adjuvant therapy with antihistamine does not reduce histamine concentrations in the middle ear fluids of children with acute otitis media. 7th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 1-5.6.1999. 6.12 Saeed K, Heikkinen T, McCormick D, Baldwin C, Chonmaitree T. A single intramuscular dose of ceftriaxone changes nasopharyngeal bacterial flora in children with acute otitis media. 7th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 1-5.6.1999. 6.13 Heikkinen T, Salmi A, Ruuskanen O. Comparison of nasopharyngeal aspirate and nasal swab for detection of influenza. II International Symposium on Influenza and Other Respiratory Viruses. Grand Cayman, British West Indies, 10-12.12.1999. 6.14 Ruohola A, Heikkinen T, Ruuskanen O. Bacterial etiology of acute otitis media with discharge through tympanostomy tubes. 26th Nordic Paediatric Congress. Helsinki, Finland, 8-11.6.2000. 6.15 Waris M, Ruuskanen O, Heikkinen T, Halonen P. A two-year cyclic pattern of RSV epidemics in Finland, 1980-2000. European Virology 2000. Glasgow, UK, 17-21.9.2000. 6.16 Heikkinen T, Salmi AA, Ruuskanen O. Comparison of nasopharyngeal aspirates and nasal swabs for isolation of respiratory viruses in children. III International Symposium on Respiratory Viral Infections. St. Lucia, West Indies, 1-3.12.2000. 6.17 Peltola V, Heikkinen T, Ruuskanen O. Influenza viruses cause more severe croup than parainfluenza viruses in hospitalized children. 19th Annual Meeting of the European Society for Paediatric Infectious Diseases. Istanbul, Turkey, 26-28.3.2001. 6.18 Ruohola A, Heikkinen T, Meurman O, Puhakka T, Lindblad N, Ruuskanen O. Randomized placebo-controlled study of antibiotic treatment of acute otitis media. 4th Extraordinary International Symposium on Recent Advances in Otitis Media. Sendai, Japan, 16-20.4.2001. 6.19 Heikkinen T, Ruohola A, Waris M, Ruuskanen O. Respiratory viruses in nasopharyngeal specimens from children with acute otitis media. 4th Extraordinary International Symposium on Recent Advances in Otitis Media. Sendai, Japan, 16-20.4.2001. 6.20 Kainulainen L, Silvennoinen H, Peltola V, Puhakka T, Jartti T, Ziegler T, Heikkinen T. Duration of symptomatic influenza illness in different age groups of children. V International Symposium on Respiratory Viral Infections. La Romana, Dominican Republic, 5-8.12.2002.

19 6.21 Puhakka T, Peltola V, Kainulainen L, Jartti T, Juvén T, Routi T, Ziegler T, Heikkinen T. Duration of rhinovirus detection by PCR in nasal swab specimens obtained after rhinovirus infection in children. V International Symposium on Respiratory Viral Infections. La Romana, Dominican Republic, 5-8.12.2002. 6.22 Nohynek HM, Kilpi TM, Nuorti JP, Salo H, Heikkinen T, Hulkko T, Koivula I, Honkanen P, K.R.A.R. Committee. Recommending use of pneumococcal conjugate vaccine (PCV) for children in Finland bases on scientific evidence and cost effectiveness analysis. 21st Annual Meeting of the European Society for Paediatric Infectious Diseases. Taormina, Sicily, 9-11.4.2003. 6.23 Heikkinen T, Silvennoinen H, Reunanen T, Ziegler T. Incidence of acute otitis media during different viral infections in children younger than three years. 8th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 3-7.6.2003. 6.24 Chonmaitree T, Saeed K, McCormick D, Uchida T, Heikkinen T, Baldwin CD. Effect of antihistamine and corticosteroid treatment in acute otitis media. 8th International Symposium on Recent Advances in Otitis Media. Ft. Lauderdale, USA, 3-7.6.2003. Heikkinen T, Silvennoinen H, Reunanen T, Ziegler T, Vainionpää R. Illness symptoms and absences due to influenza in different age groups of children. Options for the Control of Influenza V. Okinawa, Japan, 7-11.10.2003. 6.25 Heikkinen T, Reunanen T, Syvänen K, Silvennoinen H, Vainionpää R. Impact of influenza and RSV epidemics on children s visits to outpatient offices and hospital emergency department. VI International Symposium on Respiratory Viral Infections. Fort Myers, USA, 18-21.3.2004. 6.26 Ruohola A, Heikkinen T, Meurman O, Nikkari S, Salmi A, Vainionpää R, Ruuskanen O. Microbiology of acute otitis media with tympanostomy tube otorrhea. 22nd Annual Meeting of the European Society for Paediatric Infectious Diseases. Tampere, Finland, 26-28.5.2004. 6.27 Silvennoinen H, Peltola V, Ziegler T, Vainionpää R, Heikkinen T. Clinical presentation of influenza in outpatient children. 22nd Annual Meeting of the European Society for Paediatric Infectious Diseases. Tampere, Finland, 26-28.5.2004. 6.28 Peltola V, Reunanen T, Ziegler T, Silvennoinen H, Heikkinen T. Accuracy of clinical diagnosis of influenza in outpatient children. VII International Symposium on Respiratory Viral Infections. Curacao, Netherlands Antilles, 3.-6.3.2005. 6.29 Heikkinen T, Puhakka T, Pulkkinen J, Silvennoinen H, Peltola V, Kainulainen L. Comparison of spectral gradient acoustic reflectometry and tympanometry in children. 5th Extraordinary International Symposium on Recent Advances in Otitis Media. Amsterdam, The Netherlands, 24.-27.4.2005.

20 6.30 Heikkinen T, Österback R, Peltola V, Vainionpää R. Acute otitis media in children with human metapneumovirus infection. 5th Extraordinary International Symposium on Recent Advances in Otitis Media. Amsterdam, The Netherlands, 24.-27.4.2005. 6.31 Ruohola A, Heikkinen T, Meurman O, Ruuskanen O. The dynamics of the microbiology of untreated acute otitis media with tube otorrhea. 5th Extraordinary International Symposium on Recent Advances in Otitis Media. Amsterdam, The Netherlands, 24.- 27.4.2005. 6.32 Silvennoinen H, Peltola V, Kainulainen L, Ziegler T, Vainionpää R, Heikkinen T. Clinical severity of influenza A/H1N1, A/H3N2, and B infections in children. 23rd Annual Meeting of the European Society for Paediatric Infectious Diseases. Valencia, Spain, 18.-20.5.2005. 6.33 Salo H, Kilpi T, Sintonen H, Linna M, Peltola V, Heikkinen T. Cost-effectiveness of influenza vaccination of healthy children in Finland. 8th International Symposium on Respiratory Viral Infections. The Big Island, Hawaii, USA, 16.-19.3.2006. 6.34 Ruohola A, Meurman O, Nikkari S, Skottman T, Salmi A, Waris M, Österback R, Eerola E, Allander T, Niesters H, Heikkinen T, Ruuskanen O. Microbiology of acute otitis media in children with tympanostomy tubes: prevalence of bacteria and viruses. 23rd Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy. Uppsala, Sweden, 26.-29.10.2006. 6.35 Puhakka T, Peltola V, Kainulainen L, Jartti T, Juvén T, Routi T, Ziegler T, Heikkinen T. Duration of rhinovirus detection by PCR in nasal swab specimens obtained after rhinovirus infection in children. 23rd Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy. Uppsala, Sweden, 26.-29.10.2006. 6.36 Silvennoinen H, Peltola V, Vainionpää R, Ruuskanen O, Heikkinen T. Incidence of influenza-related hospitalizations in different age groups of children in Finland. 25th Annual Meeting of the European Society for Paediatric Infectious Diseases. Porto, Portugal, 2.-4.5.2007. 6.37 Waris M, Ylinen T, Ruuskanen O, Heikkinen T. Human bocavirus infections have seasonal transmission dynamics. European Society for Clinical Virology Winter Meeting. Amsterdam, The Netherlands, 7.-10.1.2009. 6.38 Heinonen S, Silvennoinen H, Ikonen N, Lehtinen P, Vainionpää R, Ziegler T, Heikkinen T. Oseltamivir resistance of influenza A(H1N1) viruses in young children in Finland during the 2007-2008 influenza season. XI International Symposium on Respiratory Viral Infections. Bangkok, Thailand, 19.-22.2.2009. 6.39 Block SL, Heikkinen T, Toback SL, Walker R, Ambrose CS, Yi T. Live attenuated influenza vaccine and reduction in influenza-associated acute otitis media in children 6-71 months. Pediatric Academic Societies Annual Meeting. Baltimore, USA, 2.-5.5.2009.

21 6.40 Heikkinen T, Österback R, Heikkinen M, Peltola V, Lehtinen P, Vainionpää R. Acute otitis media in children with human coronavirus 229E or OC43 infection. 6th Extraordinary International Symposium on Recent Advances in Otitis Media. Soul, South Korea, 6.-10.5.2009. 6.41 Koskinen JO, Söderlund-Venermo M, Hedman K, Österback R, Heikkinen T, Waris M, Allander T, Vainionpää R, Soini AE. Rapid one-step antigen detection method for human bocavirus. 19th European Congress of Clinical Microbiology and Infectious Diseases. Helsinki, Finland, 16.-19.5.2009. 6.42 Heikkinen T, Block SL, Toback SL, Walker RE, Ambrose CS, Wu X. Impact of live attenuated influenza vaccine on the development of acute otitis media in influenzainfected children 6-71 months of age. 27th Annual Meeting of the European Society for Paediatric Infectious Diseases. Brussels, Belgium, 9.-13.6.2009. 6.43 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Ziegler T, Heikkinen T. Typespecific effectiveness of inactivated influenza vaccine in children 9 months to 3 years of age. 27th Annual Meeting of the European Society for Paediatric Infectious Diseases. Brussels, Belgium, 9.-13.6.2009. 6.44 Simonsen L, Donker G, Paget J, Pitman R, Balderston C, Edelman L, Meijer A, for EPIA. European Paediatric Influenza Analysis (EPIA): Establishing multiple regression modeling needed to estimate the paediatric disease burden of influenza. 27th Annual Meeting of the European Society for Paediatric Infectious Diseases. Brussels, Belgium, 9.-13.6.2009. 6.45 Balderston C, Larrauri A, Casas I, Cuadrado TL, Paget J, Edelman L, Pitman R, Meijer A, Donker G, Simonsen L, on behalf of all EPIA collaborators. European Pediatric Influenza Analysis (EPIA): Estimating the paediatric burden of influenza in the Netherlands and Spain. European Scientific Conference on Applied Infectious Disease Epidemiology. Stockholm, Sweden, 26.-28.10.2009. 6.46 Block SL, Heikkinen T, Toback SL, Ambrose CS. Live attenuated influenza vaccine and reduction in influenza-associated acute otitis media in children aged 24-83 months. 44th National Immunization Conference. Atlanta, USA, 19.-22.4.2010. 6.47 Heikkinen T, Ashkenazi S, Belshe RB, Ambrose CS, Moren S, Zheng W. Societal impact of influenza in children: analysis of four randomized controlled studies. 28th Annual Meeting of the European Society for Paediatric Infectious Diseases. Nice, France, 4.- 8.5.2010. 6.48 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Heikkinen T. Feasibility of diagnosing influenza during the first 24 hours of symptoms in children 1-3 years of age. 28th Annual Meeting of the European Society for Paediatric Infectious Diseases. Nice, France, 4.-8.5.2010.

22 6.49 Silvennoinen H, Peltola V, Vainionpää R, Ruuskanen O, Heikkinen T. Admission diagnoses of children 0-16 years of age hospitalized for influenza-related illnesses. 28th Annual Meeting of the European Society for Paediatric Infectious Diseases. Nice, France, 4.-8.5.2010. 6.50 Balderston C, Camara AL, Casas I, Lopez Cuadrado T, Nielen M, Fleming D, Meijer A, Pnaiser R, Edelman L, Paget J, Simonsen L, and all EPIA collaborators (including Heikkinen T). Severe outcomes attributed to influenza and respiratory syncytial virus (RSV) in England, the Netherlands and Spain. 28th Annual Meeting of the European Society for Paediatric Infectious Diseases. Nice, France, 4.-8.5.2010. 6.51 Silvennoinen H, Laurikainen H, Heinonen S, Heikkinen T. Clinical diagnosis of influenza in children during an A(H3N2) epidemic. Options for the Control of Influenza VII. Hong Kong, China, 3.-7.9.2010. 6.52 Heinonen S, Peltola V, Silvennoinen H, Vahlberg T, Heikkinen T. Signs and symptoms predicting influenza in children: a case-control study. Options for the Control of Influenza VII. Hong Kong, China, 3.-7.9.2010. 6.53 Rycroft C, Leeuwenkamp O, Heikkinen T, Principi N, Herz J, Moren S, Beard S. Clinical and economic burden of paediatric influenza in nine European countries. International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 13th Annual European Congress. Prague, Czech Republic, 6.-9.11.2010. 6.54 Heinonen S, Silvennoinen H, Lehtinen P, Vainionpää R, Heikkinen T. Comparison of clinical features of influenza A and RSV infections in children 1-3 years of age. 29th Annual Meeting of the European Society for Paediatric Infectious Diseases. The Hague, the Netherlands, 7.-11.6.2011. 6.55 Heinonen S, Peltola V, Silvennoinen H, Vahlberg T, Heikkinen T. Signs and symptoms predicting influenza in children. 28th Annual Meeting of the Scandinavian Society for Antimicrobial Chemotherapy. Reykjavik, Iceland, 18.-21.8.2011. 6.56 Heinonen S, Peltola V, Silvennoinen H, Vahlberg T, Heikkinen T. Signs and symptoms predicting influenza in children: a matched case-control analysis of prospectively collected clinical data. The Fourth ESWI Influenza Conference. Malta, 11.-14.9.2011. 6.57 Heikkinen T, Block S, Toback S, Ambrose C. Does live attenuated influenza vaccine reduce all-cause acute otitis media in children? 1 st National Immunization Conference Online. 26.-28.3.2012. Available online: https://cdc.confex.com/cdc/nic2012/webprogram/paper30016.html 6.58 Heikkinen T, Block SL, Toback SL, Zheng W, Wu X, Ambrose CS. Does live attenuated influenza vaccine reduce all-cause acute otitis media in children? Pediatric Academic Societies Annual Meeting. Boston, USA, 28.4.-1.5.2012.