Curriculum Vitae PERSONAL INFORMATION Irmeli Happonen WORK EXPERIENCE January 2007 Present Head of Unit Finnish Medicines Agency, (Finland) Regulation of veterinary medicies (administration); EU cooperation; CVMP member 2007-2010 and 11/2011 - present. May 2005 December 2006 Veterinay Officer Finnish Medicines Agency, (Finland) Preclinical and clinical assessment; Pharmacovigilance; Special licence drugs; PhVWP-v member 2006. January 1991 December 2006 Clinical veterinarian/ Assistant professor/ Clinical lecturer/ Acting professor Clinical veterinarian/ Assistant professor (Jan 1991-Jul 2001); Clinical lecturer, small animal medicine (Aug 2001-Dec 2006); Acting professor (Apr 2004-Feb 2005); Small animal medicine: clinical practice, teaching, scientific research, administration. EDUCATION AND TRAINING September 1979 May 1985 Licensed veterinarian (DVM) College of Veterinary Medicine, (Finland) Veterinary medicines: health and diseases of small animals and food producing animals, food hygine (theory and clinical practice). 1987 1990 Specialist in small animal diseases (national degree) Specialisation in small animal diseases. 1996 1999 Doctor of Veterinary Medicines (PhD) Scientific research and PhD thesis on canine and feline gastric helicobacters. ADDITIONAL INFORMATION Expertise Small animal medicine: gastroenterology, endocrinology. Publications List of publications (25 international scientific publications, 16 national publications, 6 scientific abstracts, 5 scientific posters, 6 other publications) International publications: 8/1/15 European Union, 2002-2014 http://europass.cedefop.europa.eu Page 1 / 5
1. Marvola,M., Heinämäki, J., Westermarck, E. & Happonen, I. The fate of single unit enteric-coated drug products. Acta Farm Fenn, 95 (2), 1986, 59-70. 2. Heinämäki, J., Marvola, M., Happonen, I. & Westermarck, E. The fate of multiple-unit enteric-coated formulations in the stomach of the dog. Int J Pharm, 42, 1988, 105-115. 3. Marvola, M., Hannula, A-M., Westermarck, E., Happonen, I. & Kopra, T. Disintegration of hard gelatin capsule formulations in the stomach of the dog - radiological study. Int J Pharm, 44, 1988, 159-167. 4. Heinämäki, J., Marvola, M., Happonen, I. & Westermarck, E. Formulations releasing the drug in front of the pylorus in the dog. Int J Pharm, 48, 1988, 51-61. 5. Eriksson, A., Happonen, I., Mero, M. & Rauramaa, V. Feeding reduced the absorption of erythromycin in dogs. Acta Vet Scand, 31, 1990, 497-499. 6. Sirkiä, T., Marvola, M., Nikunen, S., Tuuri, L. & Happonen, I. Biopharmaceutical characterization of new douple-unit controlled release furosemide tablets. Acta Pharm Fenn, 101, 1992, 241-247. 7. Sarkiala, E., Asikainen, S., Wolf, J., Kanervo, A., Happonen, I. & Jousimies-Somer, H. Clinical, radiological and bacteriological findings in canine periodontitis. J. Small Anim. Pract., 34, 1993, 265-270. 8. Sirkiä, T., Antila, J., Marvola, M., Kauppi, M. & Happonen, I. Use of hydrophilic polymers to control drug release from press-coated oxybutin hydrochloride tablets. S.P.T. Pharma Sciences, 3 (6), 1993, 453-458. 9. Smal, J., Nurmilaukas, N., Marvola, M., Rajamäki, M. & Happonen, I. Use of ethylcellulose-coated furosemide tablets as a prolonged-release formulation for dogs. S.T.P. Pharma Sciences, 3 (6), 1993, 459-464. 10. Sirkiä, T., Niemi, J., Marvola, M., Lindqvist, T. & Happonen, I. Effect of potassium carbonate and viscosity of hydroxypropylmethylcellulose on the bioavailability of furosemide from press-coated prolonged-release tablets. S.T.P. Pharma Sciences, 4 (4), 1994, 257-263. 11. Smal, J., Haapala, O., Marvola, M., Kuusela, S. & Happonen, I. Prolonged-release hard gelatin capsules of furosemide for the treatment of dogs. J Vet Pharmacol Therap, 18, 1995, 17-23. 12. Hänninen, M.L., Jalava, K., Saari, S., Happonen, I. & Westermarck, E. Culture of "Gastrospirillum" from gastric biopsies of dogs. Eur J Clin Microbiol Infect Dis, 14, 1995, 145-146. 13. Järvinen, A.-K., Saario, E., Andersen, E., Happonen, I., Saari, S. & Rajamäki, M. Lung injury leading to respiratory distress syndrome in young dalmatian dogs. J Vet Int Med, 9 (3), 1995, 162-168. 14. Hänninen, M.-L., Happonen, I., Saari, S. & Jalava, K. Culture and characteristics of Helicobacter bizzozeronii, a new canine gastric Helicobacter sp. Int J Syst Bacteriol, 46 (1), 1996, 160-166. 15. Happonen, I., Saari, S., Castren, L., Tyni, O., Hänninen, M. L. & Westermarck, E. Occurrence and topographic mapping of gastric Helicobacter-like organisms and their association to histological changes in apparently healthy dogs and cats. J Vet Med A, 43, 1996, 305-315. 16. Happonen, I., Saari, S., Castren, L., Tyni, O., Hänninen, M.-L. & Westermarck, E. Comparison of diagnostic methods for detecting gastric Helicobacter-like organisms in dogs and cats. J Comp Path, 115, 1996, 117-127. 17. Smal, J., Marvola, M., Liljequist, C. & Happonen, I. Prolonged-release hydroxypropyl methylcellulose matrix tablets of furosemide for administration to dogs. J. Vet. Pharmacol. Therap., 19, 1996, 482-487. 18. Jalava, K., Kaartinen, M., Utriainen, M., Happonen, I. & Hänninen, M.-L. Helicobacter salomonis sp. nov., a canine gastric Helicobacter sp. related to Helicobacter felis and Helicobacter bizzozeronii. Int J Syst Bacteriol, 47 (4), 1997, 975-982. 19. Happonen, I., Linden, J., Saari, S., Karjalainen, M., Hänninen, M-L., Jalava, K., & Westermarck, E. Detection and effects of helicobacters in healthy dogs and dogs with signs of gastritis. JAVMA, 213; 1998, 1767-1774. 20. Hänninen, M-L., Happonen, I. & Jalava, K. Transmission of canine gastric Helicobacter salomonis infection from dam to offspring and between puppies. Vet Microbiol, 62; 1998, 47-58. 21. Jalava, K., On, S.L.W., Vandamme, P.A.R., Happonen, I., Sukura, A. & Hänninen, M.-L. Isolation and identification of Helicobacter spp. From canine and feline gastric mucosa. Appl Environm Microbiol 64 (10), 1998, 3998-4006. 22. Happonen, I., Linden, J. & Westermarck, E. Effect of triple therapy on eradication of canine gastric helicobacters and gastric disease. JSAP, 41 (1), 2000, 1-6. 23. Hänninen, M.-L., Utriainen, M., Happonen, I. & Dewhirst, F.E. Helicobacter sp. Flexispira 16S rdna taxa 1, 4 and 5 and Finnish porcine Helicobacter isolates are members of the species 8/1/15 European Union, 2002-2014 http://europass.cedefop.europa.eu Page 2 / 5
Helicobacter trogontum (taxon 6). Int J Syst Evol Microbiol, 53, 2003, 425-433. 24. Spillmann, T., Happonen, I., Sankari, S., Wittker, A., Kähkönen, T. & Westermarck, E. Serum values of pancreatic enzymes after endoscopic retrograde pancreatography (ERP) in healthy beagles. Am J Vet Res, 65 (5), 2004, 616-619. 25. Spillmann, T., Happonen, I., Kähkönen, T., Fyhr, T. & Westermarck, E. Endoscopic retrograde cholangio-pancreatography in healthy Beagles. Vet Radiol Ultrasound, 46 (2), 2005, 97-104. National publications: 1. Järvinen, A-K., Happonen, I. & Uusitalo, M. Koiran leptospiroosi: yleiskatsaus ja tapausselostus (Canine Leptospirosis: a review and a case report; English summary). Suomen Eläinlääkärilehti (Finnish Veterinary Journal), 92 (12), 1986, 567-575. 2. Happonen, I. Koirien perinnölliset munuaisviat (Hereditary Renal Disease). Suomen Eläinlääkäriliiton luentokokoelma (Proceedings of the Annual Meeting of Finnish Veterinary Association) 1987, 269-290. 3. Happonen, I. & Salminen, T. Matkakertomus: WSAVA/BSAVA-pieneläinkongressi Englannissa 30.3.-2.4.1989 (Travel report: WSAVA/BSAVA congress in England 1989). Suomen Eläinlääkärilehti (Finnish Veterinary Journal), 95 (6), 1989, 319-320. 4. Happonen, I. Koiran ja kissan mastiitti (Mastitis in dogs and cats; English summary). Suomen Eläinlääkärilehti (Finnish Veterinary Journal), 95 (9), 1989, 414-416. 5. Happonen, I. Röntgenkuvan laatuun vaikuttavat tekijät (Good quality radiographs). Suomen Eläinlääkäriliiton luentokokoelma (Proceedings of the Annual Meeting of Finnish Veterinary Association) 1991, 436-450. 6. Happonen, I. & Saari, S. Kasvaimen aiheuttama sappitietukos ja posthepaattinen ikterus koiralla tapausselostus (Common bile duct obstruction and posthepatic icterus in a dog a case report; English summary). Suomen Eläinlääkärilehti (Finnish Veterinary Journal), 98 (3), 1992, 124-128. 7. Happonen, I. & Saari, S. Koiran giardioosi - tapausselostus ja kirjallisuuskatsaus (Giardiosis in a dog a case report and literature review; English summary). Suomen Eläinlää kärilehti (Finnish Veterinary Journal), 100 (1), 1994, 14-18. 8. Happonen, I. Endoscopic examination of the stomach of the dog and its use in diagnosing gastric diseases. Pohjoismaisen pieneläinsairauksien symposiumin ja Suomen Eläinlääkäripraktikot r.y.:n koulutuspäivien luentokokoelma (Proceedings of Nordic Symposium on Small Animal Diseases with Annual Meeting of Finnish Association of Veterinary Practitioners) 1995. 9. Happonen, I. Canine gastric helicobacters. Proceedings of XVII Nordic Veterinary Congress 4th-7th August 1998, Helsinki, Finland, 232-235. 10. Raekallio, M. & Happonen, I. Neste-, elektrolyytti- ja happoemästasapaino. Teoksessa: M. Attila, E. Kuusela, M. Raekallio & O. Vainio (toim.) Eläinanestesiologia, 3. painos. Helsingin yliopisto, Eläinlääketieteellinen tiedekunta, Oppimateriaalia 4, Helsinki 2003, 115-120. (Fluid, electrolyte and acid-base balance. In: Veterinary Anesthesiology, 3rd ed. M. Attila, E. Kuusela, M. Raekallio & O. Vainio (eds). University of Helsinki, Faculty of Veterinary Medicine, Teaching material 4, Helsinki 2003, 115-120). 11. Happonen I. Vuoden 2004 ilmoitukset tavanomaisten eläinlääkkeiden haittavaikutuksista. Tabu 5, 2005, 34-35. (Reports of suspected adverse drug reactions of pharmaceutical veterinary medicinal products in 2004). 12. Happonen I. Vuoden 2004 ilmoitukset immunologisten eläinlääkkeiden haittavaikutuksista. Tabu 6, 2005, 25-26. (Reports of suspected adverse drug reactions of immunological veterinary medicinal products in 2004). 13. Happonen I. & Koppinen J. Erityisluvista ajankohtaisia asioita ja miksi rokotteille on vaikea saada erityislupaa. Eviran, HYELTDK:n, Lääkelaitoksen ja MMMELO:n järjestämän Lääkepäivän 19.5.2006 luentomoniste. (VMPs with special licences current status and why it is difficult to get special licence to vaccines. Drug info day 19.5.2006, lecture compendium). 14. Happonen I. Vuoden 2005 ilmoitukset tavanomaisten eläinlääkkeiden haittavaikutuksista. Tabu 6, 2006, 30-33. (Reports of suspected adverse drug reactions of pharmaceutical veterinary medicinal products in 2005). 15. Happonen I. Ajankohtaista Lääkelaitokselta; Lääkelaitoksen pohdintaa pieneläinten loislääkkeiden käytöstä rutiinihoidosta täsmähoitoon? Eviran, HYELTDK:n, Lääkelaitoksen ja MMMELO:n järjestämän Lääkepäivän 9.5.2008 luentomoniste. (Current items from the National Agency for medicines; Consideration on the use of small animal antiparasitic drugs from routine treatment to targeted treatment. Drug info day 9.5.2008, lecture compendium). 16. Happonen I. Eläinlääkkeiden myyntiluvat ja muut kulutukseen luovuttamista koskevat luvat. 8/1/15 European Union, 2002-2014 http://europass.cedefop.europa.eu Page 3 / 5
Eviran, HYELTDK:n, Lääkelaitoksen ja MMMELO:n järjestämän Lääkepäivän 15.5.2009 luentomoniste. (Marketing authorisations and other exceptional authorisations for veterinary medicinal products. Drug Info Day 15.5.2009, lecture compendium). Abstracts: 1. Heinämäki, J., Marvola, M., Happonen, I. & Westermarck, E. Formulations releasing the drug in front of the pylorus in the dog. F.I.P. -87 abstracts. 47th International Congress of Pharmaceutical Sciences of F.I.P, Amsterdam, 31.8.-4.9.1987, s. 211. 2. Järvinen, A-K., Saario, E. & Happonen, I. Respiratory distress syndrome in young dalmatian dogs. AVCIM (American College of Internal Medicine) proceedings (also oral presentation) 1992, s. 799. 3. Smal, J., Haapala, O., Kuusela, S, Happonen, I. & Marvola, M. Sustained-release furosemide hard gelatin capsules for treatment of dogs. XII Helsinki University Course in Drug Research, 17-18 June, 1993, Espoo, Finland, s. 93. 4. Smal, J., Marvola, M., Liljeqvist, C. & Happonen, I. Hydrophilic matrix tablets as a prolonged-release dosage form for the treatment of dogs. Proceedings of the Symposium on Methods to Overcome Biological Barriers in Drug Delivery, August 26-27, 1993, Kuopio, Finland, s. 67. 5. Jalava, K.-L., Saari, S., Happonen, I. & Hänninen, M.-L. Isolation and characteristics of canine gastric Helicobacters. ESVIM (European Society of Veterinary Internal Medicine) proceedings 1995, s. 67-68. 6. Happonen, I., Saari, S., Hänninen, M.-L. & Westermarck, E. Gastric Helicobacter-like organisms (GHLO) in apparently healthy dogs and cats. ESVIM (European Society of Veterinary Internal Medicine) proceedings (also oral presentation) 1995, s. 68. Posters: 1. Smal, J., Haapala, O., Kuusela, S., Happonen, I. & Marvola, M. Sustained-release furosemide hard gelatin capsules for treatment of dogs. First European Congress of Pharmaceutical Sciences, 7-9 October, 1992, Amsterdam. 2. Sirkiä, T., Marvola, M., Nikunen, S., Tuuri, L. & Happonen I. Absorption and x-ray studies of controlled-release double-unit furosemide tablets in dogs. First European Congress of Pharmaceutical Sciences, 7-9 October, 1992, Amsterdam. 3. Mäkimartti, M., Sirkiä, T., Marvola, M., Kauppi, M. & Happonen, I. Dissolution of salbutamol sulphate from controlled-release double-unit tablets. First European Congress of Pharmaceutical Sciences, 7-9 October, 1992, Amsterdam. 4. Liman, A., Mahlanen, N., Saari, S., Happonen, I., Karjalainen, M., Hänninen, M-L. & Rahko, T. Histologi cal and ultrastructural findings in gastric biopsies from clinically normal dogs and cats, with special regard to occurrence of spiral shaped bacteria. The 19th Annual Meeting and Symposium of Nordisk förening för veterinärpatologi (NFVP), 9.-10.6.1995, Helsinki, Finland. SEL (Finnish Veterinary Journal), 101 (6), 1995, 403-404. 5. Spillmann T., Happonen I. et al. Imaging of common bile duct and accessory pancreatic duct with endoscopic retrograde cholangiopancreatography in healthy dogs. Annual Finnish veterinary Meeting 1.-3.11.2006, Helsinki. Finland. Other publications: 1. Happonen, I. Koirien perinnöllisistä munuaissairauksista (Canine hereditary renal diseases). Jenkki 1/1989: 11-13 (Ameri kancocker spa nielikerho ry:n jäsenlehti, Membership Magazine of American Cockerspaniel Club) & Etelä-Suomen Spanielikerho ry:n jäsenlehti (Membership Magazine of Spaniel Club of Southern Finland) 1989. 2. Happonen, I. Kennelyskä (Kennel cough). Ajankohtaista eläinten tarttuvista taudeista - teemapäivän luentokokoelma (Compendium of the Symposium on Current Aspects of Contagious Diseases of Animals) 7.5.1991. 3. Happonen, I. Silmän ja korvan hoito sekä niiden sairauksien lääkitys (Medical management of eye and ear diseases). Lääkehuollon täydennyskoulutuskeskuksen luentokokoelma (Compendium of Continuing Education Seminar of Pharmacists) 30.1.1992. 4. Happonen, I. Mahalaukun laajentuma ja kiertymä koiralla (Canine gastric dilatation and torsion). Demodex (Klinikkaeläinhoitajat r.y:n jäsenlehti, Membership Magazine of Veterinary Nurses) 1-2, 1992. 5. Happonen, I. Portosysteeminen shuntti koiralla (Canine portosystemic shunts). Yorkshirenterrierilehti (Membership Magazine of Yorkshireterrier Club) 4/1996. 6. Happonen, I. Hyvä, paha kortisoni (Good, bad corticosteroids). Vetzer-julkaisu, Pfizer Oy (Vetzer Magazine by Pfizer), 2003. 8/1/15 European Union, 2002-2014 http://europass.cedefop.europa.eu Page 4 / 5
Projects Memberships Finnish Veterinary Association 1983 present. Finnish Association for Veterinary Practitioners, Small Animal Section 1985- present. Member, Comparative Gastroenterology Society (CGS) 1994-2004. European Society of Veterinary Internal Medicine (ESVIM) 1996-2005. Other Relevant Information 8/1/15 European Union, 2002-2014 http://europass.cedefop.europa.eu Page 5 / 5