7 November 2014 CURRICULUM VITAE

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1 CURRICULUM VITAE 7 November 2014 KONTTINEN, Yrjö Tapio, Helsinki, 28th September 1952 Institute of Clinical Medicine, Department of Medicine, Biomedicum, PO Box 700 (Haartmaninkatu 8), FI HUS, FINLAND; yrjo.konttinen@helsinki.fi CURRENT POSITION Swedish Professor of Medicine , University of Helsinki HU (Professor of Oral Medicine , Inst of Dentistry, HU) Hospital Affiliation Chief Physician of Internal Medicine, Helsinki University Central Hospital HUS Research Consultant, ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Co-Editor, Acta Orthopaedica, Vice-Director, National PhD Graduate School in Musculoskeletal Diseases and Biomaterials, Head, Musculoskeletal Diseases and Inflammation Research Group, Department of Medicine, HUS, Helsinki, Finland 1980-; and its Cell and Molecular Biology Laboratory, European Science Foundation Regenerative Medicine RNP with 14 EU member state participants (Director 5/2008-9/2011, Board Member 9/ ) POST-DOC PERIODS International Research Fellow, University of California San Diego, funded by ABROAD NIH Fogarty Center, with Professors Nathan J. Zvaifler and Harry G. Bluestein as hosts, Institute of Molecular Immunology, Hospital for Joint Diseases, NYU Medical School, New York, NY, with Professor Robert J. Winchester as the host, Rheumatology/Clinical Immunology, University of Alberta, Edmonton, Alberta, Professors Anthony S. Russell and Paul Davis Laboratoire d'histodynamique Osseuse, Université Claude-Bernard, Faculté de Médecine Alexis Carrel, and Hôpital Edouard Herriot, Lyon, France, Professor Pierre J. Meunier 711 articles in PubMed since 1979 (papers published before 1979 are by my father Yrjö Paul Herman), according to ISI Web of Science cited times, Hirsch-index being invited lectures in international meetings Sweden 17, Norway 12, Denmark 16, Iceland 2, Estonia 5, Lithuania 3, Latvia 1, Poland 1, Russia 5, Austria 4, Germany 9, France 7, Belgium 1, Italy 13, Spain 11, Switzerland 3, Hungary 2, Czech Republic 1, Netherlands 3, Portugal 10, Greece 9, Slovenia 2, England & Scotland 12, Ireland 1, Israel 4, USA 12 (New York 5, Florida 2, Texas 2, New Hampshire 1, Pennsylvania 3), Mexico 1, Canada 3, Japan 13, China 2, India 1, Romania 2. This does not include abstract and poster presentations. 45 already supervised PhD thesis works. Opponent 23, expert 27 and kustos 21 times, Member/Chair or other role of Selection Committee of Professors 12 times 70 past or present foreign visiting scientists from 32 different countries have worked in my group Member (past or present) in 13 Editorial Boards of International Peer Review Journals Peer reviews for 151 different journals Grant and other evaluations for international organizations in UK, Ireland, Germany, USA, France, Belgium, Italy, Switzerland, the Netherlands, Portugal, Czech Republic, Estonia, Lithuania, Sweden, Norway, Hong Kong, Singapore and Finland

2 LIST OF PUBLICATIONS: Yrjö T. Konttinen Section A Section B Section C Section D Section E Section F Section G Refereed original articles (followed by journal impact index) Reviews and editorials Abstracts Other publications Invited lectures, post-graduate courses, chairmanships etc. (routine weekly staff meeting, teaching as a professor and scientific abstracts are not included except those given when on leave of absence) Television and radio interviews and videos (not included) Patents A. REFEREED ORIGINAL ARTICLES 1. Konttinen YT, Reitamo S: Effect of fixation on the antigenicity of human lactoferrin in paraffin embedded tissues and cytocentrifuged cell smears. Histochemistry 62:55-64, Reitamo S, Ranki A, Konttinen YT, Häyry P: Immunoperoxidase identification of intracellular immunoglobulins from cell smears. Am J Clin Pathol 73: , Reitamo S, Konttinen YT, Segerberg-Konttinen M: Distribution of lactoferrin in human salivary glands. Histochemistry 60: , Ranki A, Reitamo S, Konttinen YT, Häyry P: Histochemical identification of human T lymphocytes from paraffin sections. J Histochem Cytochem 28: , Reitamo S, Konttinen YT, Ranki A, Häyry P: The relation of various subgroups of inflammatory cells to different structural components in rejecting kidney allograft. Histopathology 4: , Bergroth V, Reitamo S, Konttinen YT, Lalla M: Sensitivity and nonspecific staining in various immunoperoxidase techniques. Histochemistry 68:17-22, Konttinen YT, Reitamo S, Ranki A, Segerberg-Konttinen M: T lymphocytes and mononuclear phagocytes in the skin infiltrate of systemic and discoid lupus erythematosus and Jessner's lymphocytic infiltrate. Brit J Dermatol 104: , Reitamo S, Konttinen YT, Dodds S, Adinolfi M: Distribution of lactoferrin in human fetal tissues. Acta Paed Scand 70: , Bergroth V, Reitamo S, Konttinen YT, Wegelius O: Skin lesions in Waldenström's macroglobulinemia: characterization of the cellular infiltrate. Acta Med Scand 209: , Palva T, Reitamo S, Konttinen YT, Häyry P, Rinne J: Inflammatory cell subpopulations in the middle ear mucosa of ears with effusions. Int J Paed ORL 3:71-78, Reitamo S, Reitamo JJ, Konttinen YT, Collan Y, Sipponen P: Lysozyme in neoplastic Paneth cells of a jejunal adenocarcinoma. Acta Path Microbiol Scand Sect A 89: , Konttinen YT, Reitamo S, Ranki A, Häyry P, Kankaanpää U, Wegelius O: Characterization of the immunocompetent cells of rheumatoid synovium from tissue sections and eluates. Arthritis Rheum 24:71-79, Konttinen YT: In situ characterization of the cellular infiltrate in labial and palatine glands in Sjögren's syndrome. Scand J Rheumatol 10: , Reitamo S, Reunala T, Konttinen YT, Saksela O, Salo OP: Inflammatory cells, IgA, C3, fibrin and fibronectin in skin lesions in dermatitis herpetiformis. Brit J Dermatol 105: , Reitamo S, Tolvanen E, Konttinen YT, Käyhkö K, Förström L, Salo OP: Allergic and toxic contact dermatitis: Inflammatory cell subtypes of the epicutaneous test reactions. Brit J Dermatol 105: , Palva T, Tolvanen E, Konttinen YT, Reitamo S: Inflammatory cells in the middle ear mucosa in cases of chronic otitis media. Acta Otolaryngol 107: , Bergroth V, Reitamo S, Konttinen YT, Tolvanen E: Fixation-dependent cytoplasmic artefact staining with an immunoperoxidase method. Histochemistry 73: , Konttinen YT, Malmström M, Reitamo S, Tolvanen E, Seppä A, Sirelius K: Oral lesions in lichen planus and systemic lupus erythematosus: a histochemical and immunohistochemical study. Acta Path Microbiol Scand Sect A 90: , 1982

3 19. Konttinen YT, Bergroth V, Käyhkö K, Reitamo S: Human ferritin: effects of fixation and antigen source on leukocyte staining by immunoperoxidase techniques. Histochemistry 75: , Konttinen YT, Tolvanen E, Johansson E, Reitamo S, Wegelius O: Skin response to intradermal DNA and RNA in systemic lupus erythematosus. Arthritis Rheum 25: , Konttinen YT, Friman C, Tolvanen E, Reitamo S, Johansson E: Local skin rash after intra-articular methyl prednisolone acetate injection in a patient with rheumatoid arthritis. Arthritis Rheum 26: , Konttinen YT, Tolvanen E, Visa-Tolvanen K, Reitamo S, Förström L: Inflammatory cells in sarcoid granulomas detected by monoclonal antibodies and esterase technique. Clin Immunol Immunopathol 26: , Bergroth V, Konttinen YT, Reitamo S: A method for the identification of human peripheral blood T lymphocytes by sequential immunogold and esterase double staining. J Histochem Cytochem 31: , Reitamo S, Käyhkö K, Konttinen YT, Bergroth V: Factors affecting the immunoperoxidase demonstration of intracellular immunoglobulins and J chain from cytocentrifuged cell smears. J Histochem Cytochem 31: , Malmström M, Seppä A, Konttinen YT, Helve T, Reitamo S: Sjögren's syndrome in systemic lupus erythematosus and rheumatoid arthritis. Immune effector cells in salivary glands. Rheumatol Int 3:1-5, Konttinen YT, Bergroth V, Visa-Tolvanen K, Reitamo S, Förström L: Cellular infiltrate in situ and response kinetics of human intradermal and epicutaneous tuberculin reactions. Clin Immunol Immunopathol 28: , Kilpi A, Bergroth V, Konttinen YT, Maury P, Reitamo S, Wegelius O: Lymphocytic infiltrations of gastric mucosa in Sjögren's syndrome. An immunoperoxidase study using monoclonal antibodies in the avidin-biotin-peroxidase method. Arthritis Rheum 26: , Kilpi A, Konttinen YT, Malmström M, Bergroth V, Reitamo S, Helve T: Immunocompetent cells in labial salivary glands in secondary Sjögren's syndrome associated with SLE. J Oral Pathol 12: , Ranki A, Kanerva L, Förström L, Konttinen YT, Mustakallio KK: T and B lymphocytes, macrophages and Langerhans cells during the course of contact and irritant skin reactions in man. Acta Derm-Venereol (Stockh) 63: , Konttinen YT, Kulomaa M, Malmström M, Kilpi A, Reitamo S: Lactoferrin in Sjögren's syndrome. Arthritis Rheum 27: , Tolvanen E, Konttinen YT, Visa-Tolvanen K, Reunala T, Reitamo S, Kähönen K: Immunocompetent and accessory cells in dermatitis herpetiformis. Clin Immunol Immunopathol 30: , Kähönen K, Palva T, Bergroth V, Konttinen YT, Reitamo S: Immunohistochemical identification of inflammatory cells in secretary and chronic otitis media and cholesteatoma using monoclonal antibodies. Acta Otolaryngol 97: , Konttinen YT, Bluestein HG, Zvaifler NJ: Regulation of the growth of Epstein-Barr virus infected B cells. I. Growth regression by E-rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8 memory cells. J Immunol 134: , Bergroth V, Konttinen YT, Nykänen P, von Essen R, Koota K: Proliferating cells in the synovial fluid in rheumatic diseases: an analysis with autoradiography-immunoperoxidase double staining. Scand J Immunol 22: , Konttinen YT, Bergroth V, Nykänen P: Lymphocyte activation in rheumatoid arthritis synovial fluid in vivo. Scand J Immunol 22: , Konttinen YT, Bergroth V, Nordström D, Koota K, Skrifvars B, Hagman G, Friman C, Hämäläinen M, Slätis P: Cellular immunohistopathology of acute, subacute and chronic synovitis in rheumatoid arthritis. Ann Rheum Dis 44: , Bergroth V, Konttinen YT, Johansson E: Langerhans cells in SLE skin: a role in lymphocyte migration and activation in situ. Scand J Rheumatol 14: , Nordström D, Konttinen YT, Bergroth V, Leirisalo-Repo M: Synovial fluid cells in Reiter's Syndrome. Ann Rheum Dis 44: , 1985

4 39. Konttinen YT, Bergroth V, Kunnamo I, Haapasaari J: The value of biopsy in patients with monoarticular juvenile rheumatoid arthritis of recent onset. Arthritis Rheum 29:47-53, Konttinen YT, Bluestein HG, Zvaifler NJ: Regulation of the growth of Epstein-Barr virus infected B cells: Temporal profile of the in vitro development of three distinct cytotoxic cells. Cellular Immunol 103:84-95, Bergroth V, Konttinen YT, Segerberg-Konttinen M, Ollikainen V, Salaspuro M: Phenotypic in situ characterization of lymphocytes in mild alcoholic liver diseases. Acta Pathol Microbiol Scand Sect A 94: , Konttinen YT, Nordström D, Bergroth V, Leirisalo-Repo M, Skrifvars B: Cell-mediated immune response in the diseased joints in patients with reactive arthritis. Scand J Immunol 23: , Konttinen YT, Bergroth V, Nordström D, Segerberg-Konttinen M, Tolvanen E: Expression of MHC class II antigen, interleukin-2 receptor, transferrin receptor and gp 40/80 glycoprotein during different phases of a normal PHA driven lymphocyte activation in vitro. Acta Pathol Microbiol Scand Sect C 94: , Lindqvist C, Santavirta S, Sandelin J, Konttinen YT: Dysphagia and micrognathia in a patient with juvenile rheumatoid arthritis. Clin Rheumatol 5: , Nykänen P, Bergroth V, Raunio P, Nordström D, Konttinen YT: Phenotypic characterization of 3 H-thymidine incorporating cells in rheumatoid arthritis synovial membrane. Rheumatol Int 6: , Konttinen YT, Bergroth V, Nordström D, Segerberg-Konttinen M, Seppälä K, Salaspuro M: Lymphocyte activation in vivo in the intestinal mucosa of patients with Crohn`s disease. J Clin Lab Immunol 22:59-63, Santavirta S, Slätis P, Sandelin J, Lindqvist C, Konttinen YT: Atlanto-axial subluxation in patients with seronegative spondylarthritis. Rheumatol Int 7:43-46, Bergroth V, Konttinen YT, Nordström D, Pettersson T, Tolvanen E: Lymphocyte subpopulations, activation phenotypes and spontaneous proliferation in tuberculous pleural effusions. Chest 91: , Konttinen YT, Kinnunen E, von Bonsdorff M, Lillqvist P, Immonen I, Bergroth V, Segerberg- Konttinen M, Friman C: Acute transverse myelopathy successfully treated with plasmapheresis and prednisone in a patient with primary Sjögren's syndrome. Arthritis Rheum 30: , Konttinen YT, Bergroth V, Santavirta S, Sandelin J: Inflammatory involvement of cervical spine ligaments in rheumatoid arthritis patients with atlanto-axial subluxation. J Rheumatol 14: , Nordström D, Konttinen YT, Bergroth V, Segerberg-Konttinen M, Santavirta S: T cell subsets in the blast cell population in phytohemagglutinin-stimulated peripheral blood in vitro and in rheumatoid arthritis synovial fluid in vivo. Rheumatol Int 7:67-70, Segerberg-Konttinen M, Bergroth V, Jungell P, Malmström M, Sane J, Immonen I, Nordström D, Konttinen YT: T lymphocyte activation state in the minor salivary glands of patients with Sjögren's syndrome. Ann Rheum Dis 46: , Konttinen YT, Bergroth V, Johansson E, Nordström D, Malmström M: A long-term clinicopathological survey of patients with Jessner's lymphocytic infiltration of the skin. J Invest Dermatol 89: , Konttinen YT, Bergroth V, Kinnunen E, Nordström D, Kouri T: Activated T lymphocytes in patients with multiple sclerosis in clinical remission. J Neurol Sci 81: , Santavirta S, Lamberg M, Kiviluoto O, Konttinen YT, Möller C: Zervikale Spondylitis als Folge der Gummi-ligaturbehandlung von Hämorrhoiden. Zentralbl Chir 112: , Konttinen YT, Bergroth V, Nordström D, Tallgren LG, von Bonsdorff M, Santavirta S: IgA nephropathy in reactive arthritis. J Rheumatol 14: , Jungell P, Malmström M, Wartiovaara J, Konttinen YT, Sane J: Ultrastructure of oral leukoplakia and lichen planus. I. Basal region and inflammatory cells. J Oral Pathol 16: , Jungell P, Malmström M, Wartiovaara J, Konttinen YT: Ultrastructure of oral leukoplakia and lichen planus. II. A correlated scanning- and transmission electron microscopic study of epithelial surface cells. J Oral Pathol 16: , Bergroth V, Konttinen YT, Nordström D, Laasonen L: The loin pain/haematuria syndromepossible association with intrarenal arterial spasms. Br Med J 294:1657, 1987

5 60. Santavirta S, Hopfner-Hallikainen D, Paukku P, Sandelin J, Konttinen YT: Atlanto-axial facet joint arthritis in the rheumatoid cervical spine. A panoramic zonography study. J Rheumatol 15: , Malmström M, Konttinen YT, Jungell P, Bergroth V, Segerberg-Konttinen M, Nordström D: Lymphocyte activation in oral lichen planus in situ. Am J Clin Pathol 89: , Bergroth V, Konttinen YT, Piirainen H, Johansson E, Nordström D, Malmström M: Evaluation of lymphocyte activation in skin lesions of patients with mixed connective tissue disease and discoid lupus erythematodes. Arch Dermatol Res 280:1-4, Malmström MJ, Segerberg-Konttinen M, Tuominen TS, Hietanen JH, Wolf JE, Sane JI, Konttinen YT: Xerostomia due to Sjögren's syndrome. Diagnostic criteria, treatment and outlines for a continuous dental care program and an open trial with Sulfarlem R. Scand J Rheumatol 17:77-86, Bergroth V, Konttinen YT, Pelkonen P, Haapala M, Haapasaari J, Nordström D, Kunnamo I, Friman C: Synovial fluid lymphocytes in various subtypes of juvenile rheumatoid arthritis. Arthritis Rheum 31: , Santavirta S, Bardy B, Tukiainen E, Konttinen YT, Ahovuo J, Björkenheim J-M: Why does high tibial osteotomy occasionally fail? J Orthop Rheumatol 1:41-50, Eskola A, Santavirta S, Konttinen YT, Tallroth K, Hoikka V, Lindholm ST: Cementless total replacement for old tuberculosis of the hip. J Bone Joint Surg (Br) 70-B: , Santavirta S, Eskola A, Konttinen YT, Tallroth K, Lindholm ST: Total hip replacement in old tuberculosis. A report of 14 cases. Acta Orthop Scand 59: , Konttinen YT, Segerberg-Konttinen M, Nordström D, Bergroth V, Scheinin T, Saari H: An immunoperoxidase-autoradiography double labeling method for analysis of lymphocyte activation markers and DNA synthesis. J Immunol Methods 110:19-27, Eskola A, Santavirta S, Konttinen YT, Tallroth K, Lindholm ST: Arthroplasty for old tuberculosis of the knee. J Bone Joint Surg (Br) 70-B: , Santavirta S, Wennerstrand M, Konttinen YT, Ahovuo J, Saari H: Long-term follow-up of Geomedic knee arthroplasties. J Orthop Rheumatol 1: , Konttinen YT, Nordström D, Bergroth V, Leirisalo-Repo M, Santavirta S: Occurrence of different ensuing triggering infections preceding reactive arthritis: a follow-up study. Br Med J 296: , Mussalo-Rauhamaa H, Konttinen YT, Lehto J, Honkanen V: Predictive clinical and laboratory parameters for serum zinc and copper in rheumatoid arthritis. Ann Rheum Dis 47: , Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvuo M, Kaprio J: Genetic susceptibility to multiple sclerosis. A co-twin study of a nationwide series. Arch Neurol 45: , Grönblad M, Konttinen YT, Korkala O, Liesi P, Hukkanen M, Polak JM: Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 15: , Stephansson EA, Konttinen YT, Raunio V, Salo OP: DNA skin tests in patients with definite or suspected systemic lupus erythematosus and in dermatological control patients. A long-term follow-up study. Scand J Rheumatol 18: , Sorsa T, Konttinen YT, Lauhio A, Saari H, Suomalainen K, Lindy S: Gold (I) compounds and human neutrophil collagenase. J Rheumatol 16: , Saari H, Konttinen YT, Santavirta S: Synovial fluid hyaluronate: a study using high performance liquid chromatography with size exclusion column. Med Sci Res 17:99-101, Konttinen YT, Hoikka V, Landtman M, Saari H, Santavirta S, Metsärinne K, Seegmiller JE: Alkaptonuria/ochronosis: a report of a case and a review of literature. Clin Exp Rheumatol 7: , Konttinen YT, Santavirta S, Kauppi M, Isomäki H, Slätis P, Hämäläinen M, Sakaguchi M: Atlantoaxial laxity in rheumatoid arthritis. Acta Orthop Scand 60: , Santavirta S, Konttinen YT, Nordström D, Bergroth V, Antti-Poika I, Eskola A: Immuneinflammatory response in infected arthroplasties. Acta Orthop Scand 60: , Kinnunen E, Konttinen YT, Bergroth V, Kemppinen P: Immunological studies on patients with opticus neuritis without evidence of multiple sclerosis. Arch Neurol 90:43-52, 1989

6 82. Konttinen YT, Segerberg-Konttinen M, Guseva N, Keinonen M, Kirtava ZZ, Kaarela K, Molander G, Lehtinen K, Sorsa S: Subjective disease experience in Sjögren's syndrome. A computerized discrimination analysis. Scand J Rheumatol 18:13-20, Konttinen YT, Jungell P, Bergroth V, Hampf G, Kemppinen P, Malmström M: PHA stimulation of peripheral blood lymphocytes in oral lichen planus. Abnormality localized between interleukin-2 receptor ligand formation and gamma-interferon secretion. J Clin Lab Immunol 28:33-37, Slätis P, Santavirta S, Sandelin J, Konttinen YT: Cranial subluxation of the odontoid process in rheumatoid arthritis. J Bone Joint Surg (Am) 71: , Konttinen YT, Nykänen P, Nordström D, Saari H, Sandelin J, Santavirta S, Kouri T: DNA synthesis in prolyl 4-hydroxylase positive fibroblasts in situ in synovial tissue. An autoradiography-immunoperoxidase double labeling study. J Rheumatol 16: , Saari H, Konttinen YT: Determination of synovial fluid hyaluronate concentration and polymerization by high performance liquid chromatography. Ann Rheum Dis 48: , Sorsa T, Suomalainen K, Konttinen YT, Saari HT, Lindy S: Identification of protease(s) capable of further degrading native 3/4- and 1/4 -collagen fragments generated by collagenase from native type I collagen in human neutrophils. Proc Finn Dental Soc 85:3-11, Saari H, Konttinen YT, Tulamo R-M, Antti-Poika I, Honkanen V: Concentration and degree of polymerization of hyaluronate in equine synovial fluid. Am J Vet Res 50: , Antti-Poika I, Santavirta S, Konttinen YT, Honkanen V: Outcome of the infected hip arthroplasty. A retrospective study of 36 patients. Acta Orthop Scand 60: , Honkanen V, Konttinen YT, Mussalo-Rauhamaa H: Vitamin A, E, retinol binding protein and zinc in rheumatoid arthritis. Clin Exp Rheumatol 7: , Konttinen YT, Bergroth V, Kulomaa M, Nordström D, Segerberg-Konttinen M, Keinänen R, Kemppinen P, Hukkanen M, Grönblad M: Localization of lysozyme mrna in rheumatoid synovial membrane by in situ hybridization. Ann Rheum Dis 48: , Tallroth K, Eskola A, Santavirta S, Konttinen YT, Lindholm TS: Aggressive granulomatous lesions after hip arthroplasty. J Bone Joint Surg (Br) 71-B: , Jungell P, Konttinen YT, Nortamo P, Malmström M: Immunoelectron microscopic study of distribution of T cell subsets in oral lichen planus. Scand J Dent Res 97: , Konttinen YT, Grönblad M, Bergroth V, Santavirta S, Antti-Poika I: Presence of platelet glycoprotein Ib and IIb-IIIa in inflammatory and non-inflammatory synovium. J Rheumatol 16: , Mashkilleyson N, Konttinen YT, Visa K: Local involvement of antigen-presenting cells and activated T cells in perilesional and clinically uninvolved skin in pemphigus vulgaris. Acta Derm- Venereol (Stockh) 69: , Sorsa T, Saari H, Konttinen YT, Uitto V-J, Lindy S: Human neutrophil collagenase and oxygen derived free radicals. N Engl J Med 321: , Santavirta S, Antti-Poika I, Konttinen YT: Risk of fatal outcome in infected hip arthroplasty. J Orthop Rheumatol 2: , Suominen S, Antti-Poika I, Santavirta S, Konttinen YT: Infection of total hip arthroplasty. Treatment with resection arthroplasty and late hip rearthroplasty. Hokkaido J Orthop 33:55-60, Santavirta S, Konttinen YT, Sandelin J, Slätis P: Operations for the unstable cervical spine in rheumatoid arthritis. Sixteen cases of subaxial subluxation. Acta Orthop Scand 61: , Malmström M, Ruokonen H, Konttinen YT, Bergroth V, Segerberg-Konttinen M, Hietanen J, Nordström D, Haapala M: Herpes simplex virus antigens and inflammatory cells in recurrent oral lesions in recurrent erythema multiforme. Immunoperoxidase, autoradiographical and electron microscopical studies. Acta Derm-Venereol (Stockh) 70: , Nykänen PJ, Konttinen YT, Bergroth V: Chemoattractant production by synovial fluid cells in chronic arthritis. A study with a new double-chamber method for quantitating the motility of mononuclear cells labelled with chromium-51. Clin Rheumatol 9: , Konttinen YT, Kulomaa M, Segerberg-Konttinen M, Nordström D, Keinänen R, Grönblad M, Malmström M: Localization of lysozyme mrna in the labial salivary glands by in situ hybridization in Sjögren's syndrome. Scand J Dent Res 98: , 1990

7 103. Kinnunen E, Juntunen J, Konttinen YT, Kemppinen P, Koskimies S, Ketonen L, Kleemola P, Koskenvuo M: Multiple sclerosis and systemic lupus erythematosus in twins of successive generations. Acta Neurol Scand 81: , Konttinen YT, Santavirta S, Grönblad M, Kauppi M, Sakaguchi M, Hämäläinen M, Michelsson J- E, Polak JM, Dahl D: A retrospective clinical and neuroimmunohistochemical study of rheumatoid arthritis patients with atlanto-axial subluxation. Scand J Rheumatol 19:43-49, Konttinen YT, Pettersson T, Kemppinen P, Friman C: Spontaneous and in vitro activation of synovial fluid and peripheral blood lymphocytes in rheumatoid arthritis. Clin Rheumatol 9: , Konttinen YT, Tuominen S, Piirainen H, Könönen M, Wolf J, Hietanen J, Malmström M: Signs and symptoms in the masticatory system in ten patients with mixed connective tissue disease. Scand J Rheumatol 19: , Konttinen YT, Grönblad M, Antti-Poika I, Seitsalo S, Santavirta S, Hukkanen M, Polak JM: Neuroimmunohistological analysis of peridiscal nociceptive neural elements. Spine 15: , Konttinen YT, Kinnunen E, Kemppinen P, Juntunen J, Koskenvuo M: Lymphocyte activation in discordant multiple sclerosis twin pairs. J Neuroimmunol 27:1-8, Konttinen YT, von Essen R, Grönblad M, Vahvanen V, Santavirta S, Antti-Poika I, Hämäläinen M: Fibroblasts in synovitis in rheumatoid arthritis but not in non-inflammatory synovial tissue in meniscus lesions express the carboxyterminal domain of procollagen type I. Am J Clin Pathol 93: , Konttinen YT, Michelsson J-E, Tolvanen E, Bergroth V: Primary inflammatory reaction in synovial fluid and tissue in rabbit immobilization osteoarthritis. Clin Orthop Res 260: , Kinnunen E, Kauppi M, Ketonen L, Sepponen R, Tanttu J, Konttinen YT, Isomäki H: Low-field MRI in the evaluation of rheumatoid cervical spine. Comparison with neurological findings and routine plain radiography. Clin Exp Rheumatol 8: , Wirta J, Eskola A, Santavirta S, Tallroth K, Konttinen YT, Lindholm S: Revision of aggressive granulomatous lesions in hip arthroplasty. J Arthroplasty 5 Suppl:S47-52, Kauppi M, Sakaguchi M, Konttinen YT, Hämäläinen M: A new method of screening for vertical atlanto-axial dislocation. J Rheumatol 17: , Konttinen YT, Grönblad M, Korkala O, Tolvanen E, Polak JM: Immunohistochemical demonstration of subclasses of inflammatory cells and active, collagen-producing fibroblasts in the synovial plicae of lumbar facet joints. Spine 15: , Antti-Poika I, Soini J, Tallroth K, Yrjönen T, Konttinen YT: Clinical relevance of discography combined with CT scanning. A study of 100 patients. J Bone Joint Surg (Br) 72-B: , Tulamo R-M, Saari H, Konttinen YT: Determination of concentration of hyaluronate in equine serum. Am J Vet Res 51: , Janin A, Konttinen YT, Grönblad M, Karhunen P, Gosset D, Malmström M: Fibroblast markers in labial salivary gland biopsies in progressive systemic sclerosis. Clin Exp Rheumatol 8: , Eskola A, Santavirta S, Konttinen YT, Hoikka V, Tallroth K, Lindholm TS: Cementless revision of aggressive granulomatous lesions in hip replacements. J Bone Joint Surg (Br) 72-B: , Santavirta S, Konttinen YT, Bergroth V, Eskola A, Tallroth K, Lindholm TS: Aggressive granulomatous lesions associated with hip arthroplasty. Immunopathological studies. J Bone Joint Surg (Am) 72-A: , Konttinen YT, Tuominen S, Segerberg-Konttinen M, Jungell P, Malmström MJ, Grönblad M, Güven O, Santavirta S, Panula P: Mast cells in the labial salivary glands of patients with Sjögren's syndrome: a histological, immunohistochemical, and electron microscopical study. Ann Rheum Dis 49: , Santavirta S, Konttinen YT, Saito T, Grönblad M, Partio E, Kemppinen P, Rokkanen P: Immune response to polyglycolic acid implants. J Bone Joint Surg (Br) 72-B: , Grönblad M, Lukinmaa A, Konttinen YT: Chronic low-back pain: Intercorrelation of repeated measures for pain and disability. Scand J Rehab Med 22:73-77, 1990

8 123. Konttinen YT, Rees R, Hukkanen M, Grönblad M, Tolvanen E, Gibson SJ, Polak JM, Brewerton DA: Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritic rat model. J Rheumatol 17: , Santavirta S, Hoikka V, Eskola A, Konttinen YT, Paavilainen T, Tallroth K: Aggressive granulomatous lesions in cementless total hip arthroplasty. J Bone Joint Surg (Br) 72-B: , Santavirta S, Konttinen YT, Sandelin J, Grönblad M, Antti-Poika I: Cervical spine subluxation in ankylosing spondylitis treated surgically. J Orthop Rheumatol 3:57-60, Sorsa T, Helenius J, Suomalainen K, Lindy S, Saari H, Konttinen YT, Uitto V-J: Chlorhexidine and autoactivation of collagenase by human neutrophils. N Engl J Med 323: , Honkanen VEA, Pelkonen P, Konttinen YT, Mussalo-Rauhamaa H, Lehto J, Westermarck T: Serum cholesterol and vitamins A and E in juvenile chronic arthritis. Clin Exp Rheumatol 8: , Saari H, Suomalainen K, Lindy O, Konttinen YT, Sorsa T: Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases. Biochem Biophys Res Commun 171: , Konttinen YT, Saari H, Honkanen V, Szocsik K, Mussalo-Rauhamaa H, Friman C: Serum baseline hyaluronate and disease activity in rheumatoid arthritis. Clin Chim Acta 193:39-47, Tallroth K, Antti-Poika I, Konttinen YT, Soini J, Honkanen V, Yrjönen T: Premedication and short term complications in iohexol discography. Ann Chir Gynaecol 80:49-53, Saari H, Konttinen YT, Nordström D: The effect of joint mobilization on serum hyaluronate. Ann Med 23:29-32, Konttinen YT, Saari H, Nordström D: Effect of interleukin-1 on hyaluronate synthesis by synovial fibroblastic cells. Clin Rheumatol 10: , Soini J, Antti-Poika I, Tallroth K, Konttinen YT, Honkanen V, Santavirta S: Disc degeneration and angular movement of the lumbar spine. A comparative study using plain and flexion-extension radiography and discography. J Spinal Disorders 4: , Konttinen YT, Lindy O, Kemppinen P, Saari H, Suomalainen K, Vauhkonen M, Lindy S, Sorsa T: Collagenase reserves in polymorphonuclear neutrophil leukocytes from synovial fluid and peripheral blood of patients with rheumatoid arthritis. Matrix 11: , Hukkanen M, Grönblad M, Rees R, Konttinen YT, Gibson S, Hietanen J, Polak JM, Brewerton D: Regional distribution of mast cells and peptide-containing nerves in normal and adjuvant arthritic rat synovium. J Rheumatol 18: , Grönblad M, Korkala O, Konttinen YT, Nederström A, Hukkanen M, Tolvanen E, Polak JM: Silver impregnation and immunohistochemical study of nerves in lumbar facet joint plical tissue. Spine 16:34-38, Konttinen YT, Michelsson J-E, Grönblad M, Jaakkola L, Honkanen V: Plasma hyaluronate levels in rabbit immobilization osteoarthritis: effect of remobilization. Scand J Rheumatol 20: , Grönblad M, Korkala O, Konttinen YT, Kuokkanen H, Liesi P: Immunoreactive neuropeptides in nerves in ligamentous tissue. An experimental neuroimmunohistochemical study. Clin Orthop Res 265: , Kauppi M, Konttinen YT, Honkanen V, Sakaguchi M, Hämäläinen M, Santavirta S: A multivariate analysis of risk factors for anterior atlantoaxial subluxation and evaluation of the effect of glucocorticoid treatment on the upper rheumatoid cervical spine. Clin Rheumatol 10: , Konttinen YT, Santavirta N, Honkanen V, Sandelin S, Schauman L, Grönblad M: Systemic lupus erythematosus patient guide: influence on knowledge of the disease. Ann Rheum Dis 50: , Santavirta S, Konttinen YT, Bergroth V, Grönblad M: Lack of immune response to methyl methacrylate in lymphocyte cultures. Acta Orthop Scand 62:29-32, Santavirta S, Konttinen YT, Laasonen E, Honkanen V, Antti-Poika I, Kauppi M: Ten-year results of operations for rheumatoid cervical spine disorders. J Bone Joint Surg (Br) 73-B: , Santavirta S, Konttinen YT, Hoikka V, Eskola A: Immunopathological response to loose cementless acetabular components. J Bone Joint Surg (Br) 73-B:38-42, 1991

9 144. Suomalainen K, Sorsa T, Lindy O, Saari H, Konttinen YT, Uitto V-J: Hypochlorous acid induced activation of human neutrophil and gingival crevicular fluid collagenase can be inhibited by ascorbate. Scand J Dent Res 99: , Santavirta S, Nordström D, Ylinen P, Konttinen YT, Silvennoinen T, Rokkanen P: Biocompatibility of hydroxyapatite-coated hip prostheses. Arch Orthop Trauma Surg 110: , Konttinen YT, Lindy O, Suomalainen K, Ritchlin C, Saari H, Vauhkonen M, Lauhio A, Santavirta S, Sorsa T: Substrate specificity and activation mechanisms of collagenase from human rheumatoid synovium. Matrix Biol 11: , Honkanen V, Konttinen YT, Sorsa T, Hukkanen M, Kemppinen P, Santavirta S, Saari H, Westermarck T: Serum zinc, copper and selenium in rheumatoid arthritis. J Trace Elem Electrol Health Dis 5: , Honkanen VEA, Lamberg-Allardt C, Vesterinen MK, Lehto JH, Westermarck TW, Metsä-Ketelä TK, Mussalo-Rauhamaa MH, Konttinen YT: Plasma zinc and copper concentrations in rheumatoid arthritis: influence of dietary factors and disease activity. Am J Clin Nutr 54: , Suominen S, Antti-Poika I, Santavirta S, Konttinen YT, Honkanen V, Lindholm TS: Total hip replacement after intertrochanteric osteotomy. Orthopedics 3: , Häyrinen-Immonen R, Nordström D, Malmström M, Hietanen J, Konttinen YT: Immuneinflammatory cells in recurrent oral ulcers (ROU). Scand J Dent Res 99: , Santavirta S, Pajamäki J, Eskola A, Konttinen YT, Lindholm TS: Proliferative cell response to the loosening of THR. A cytofluorographic cell cycle analysis. Arch Orthop Trauma Surg 111:43-46, Konttinen YT, Honkanen VEA, Grönblad MÅ, Keinonen M, Santavirta N, Santavirta S: The relation of extra-articular tenderness to inflammatory joint disease and personality in patients with rheumatoid arthritis. J Rheumatol 19: , Saari H, Tulamo R-M, Konttinen YT, Sorsa T: Methylprednisolone acetate -induced release of cartilage proteoglycans: determination by high-performance liquid chromatography (HPLC). Ann Rheum Dis 51: , Konttinen YT, Hukkanen M, Segerberg M, Rees R, Kemppinen P, Sorsa T, Saari H, Polak JM, Santavirta S: Relationship between neuropeptide immunoreactive nerves and inflammatory cells in adjuvant arthritic rats. Scand J Rheumatol 21:55-59, Hukkanen M, Konttinen YT, Rees RG, Gibson SJ, Santavirta S, Polak JM: Innervation of bone from healthy and arthritic rats by substance P and calcitonin gene related peptide containing sensory fibers. J Rheumatol 19: , Santavirta S, Nordström D, Saari H, Paavolainen P, Konttinen YT: Immune-inflammatory response in the loosening of the totally replaced hip. J Orthop Rheumatol 5:71-77, Konttinen YT, Kemppinen P, Segerberg-Konttinen M, Sorsa T, Saari H, Hukkanen M: Reactive oxygen species induced structural alterations of substance P. Mediators Inflam 1: , Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee H-M, Uitto V-J, Saari H, Konttinen YT: Specificity of the anti-collagenase action of tetracyclines: relevance to their anti-inflammatory potential. Antimicrobial Agents Chemother 36: , Konttinen YT, Hukkanen M, Kemppinen P, Segerberg M, Sorsa T, Malmström M, Rose S, Itescu S, Polak JM: Peptide-containing nerves in labial salivary glands in Sjögren's syndrome. Arthritis Rheum 35: , Santavirta S, Konttinen YT, Heliövaara M, Knekt P, Lüthje P, Aromaa A: Determinants of osteoporotic thoracic vertebral fracture. Acta Orthop Scand 63: , Konttinen YT, Sorsa T, Hukkanen M, Segerberg M, Kuhlefelt-Sundström M, Malmström M, Polak JM: Topology of innervation of labial salivary glands by protein gene product 9.5- and synaptophysin-immunoreactive nerves in patients with Sjögren's syndrome. J Rheumatol 19:30-37, Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT: The anticollagenolytic potential of lymecycline in long-term treatment of reactive arthritis. Arthritis Rheum 35: , Santavirta S, Konttinen YT, Antti-Poika I, Nordström D: Inflammation of the subacromial bursa in chronic shoulder pain. Arch Orthop Trauma Surg 111: , 1992

10 164. Sorsa T, Ingman T, Suomalainen K, Halinen S, Saari H, Konttinen YT, Uitto V-J, Golub LM: Cellular source and tetracycline-inhibition of gingival crevicular fluid collagenase of patients with labile diabetes mellitus. J Clin Periodontol 19: , Metsärinne K, Nordström D, Teppo AM, Konttinen YT, Fyhrquist F: Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis and systemic lupus erythematosus. Rheumatol Int 12:93-96, Hukkanen M, Konttinen YT, Rees RG, Santavirta S, Terenghi G, Polak JM: Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone. Int J Tissue Reactions 14:1-10, Saari H, Sorsa T, Lindy O, Suomalainen K, Halinen S, Konttinen YT: Reactive oxygen species and hyaluronate in serum and synovial fluid in arthritis. Int J Tissue Reactions 14: , Hukkanen M, Konttinen YT, Terenghi G, Polak JM: Peptide-containing innervation of rat femoral lymphatic vessels. Microvascular Res 43:7-19, Häyrinen-Immonen R, Malmström M, Nordström D, Sorsa T, Konttinen YT: Distribution of adhesion receptors in recurrent oral ulcers. J Oral Pathol Med 21: , Nordström D, Konttinen YT, Sorsa T, Nykänen P, Pettersson T, Santavirta S, Tschopp J: Granzyme A -immunoreactive cells in synovial fluid in rheumatoid and reactive arthritis. Clin Rheumatol 11: , Santavirta S, Konttinen YT, Nordström D, Mäkelä A, Sorsa T, Hukkanen M, Rokkanen P: Immunologic studies of nonunited fractures. Acta Orthop Scand 63: , Konttinen YT, Santavirta S, Paavolainen P, Antti-Poika I, Tiainen T, Nordström D, Hukkanen M: Immunoreactive neuropeptide nerves in ligamentous tissue in chronic shoulder pain. Arch Orthop Trauma Surg 111: , Suomalainen K, Halinen S, Ingman T, Lindy O, Saari H, Konttinen YT, Golub LM, Sorsa T: Tetracyclin inhibition identifies the cellular sources of interstitial collagenase in gingival crevicular fluid in different forms of periodontal diseases. Drugs Exp Clin Res 18:99-104, Gray C, Hukkanen M, Konttinen YT, Terenghi G, Arnett TR, Jones SJ, Burnstock G, Polak JM: Rapid neural growth: calcitonin gene-related peptide and substance P-containing nerves attain exceptional growth rates in regenerating deer antler. Neuroscience 50: , Sorsa T, Ingman T, Suomalainen K, Haapasalo M, Konttinen YT, Lindy O, Saari H, Uitto V-J: Identification of proteases from potent periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases. Infect Immun 60: , Saari H, Konttinen YT, Friman C, Sorsa T: Differential effects of reactive oxygen species on native synovial fluid and purified human umbilical cord hyaluronate. Inflammation 17: , Santavirta S, Sorsa T, Konttinen YT, Saari H, Eskola A, Eisen AZ: Role of mesenchymal collagenase in the loosening of total hip prosthesis. Clin Orthop Res 290: , Saari H, Törnwall J, Halinen S, Tulamo R-M, Sorsa T, Lauhio A, Konttinen YT: The simultaneous determination of hyaluronate and proteoglycan subunits from synovial fluid by high performance liquid chromatography. Progr Rheumatol 5:10-14, Saari H, Santavirta S, Nordström D, Paavolainen P, Konttinen YT: Hyaluronate in total hip replacement. J Rheumatol 20:87-90, Santavirta S, Grönblad M, Antti-Poika I, Konttinen YT, Polak JM: Protein gene product 9.5- (PGP 9.5-), synaptophysin- and neuropeptide-immunoreactive nerves in human subacromial bursal tissue. Eur J Exp Musculoskel Res 2:93-99, Ruokonen H, Hietanen J, Malmström M, Sane J, Häyrinen-Immonen R, Hukkanen M, Konttinen YT: Peripheral nerves and mast cells in normal buccal mucosa. J Oral Pathol Med 22:30-34, Häyrinen-Immonen R, Sorsa T, Nordström D, Malmström M, Konttinen YT: Collagenase and stromelysin in recurrent aphthous ulcers (RAU). Int J Oral Maxillofac Surg 22:46-49, Santavirta S, Nordström D, Tallroth K, Eskola A, Hoikka V, Paavilainen T, Konttinen YT: Granulomatous reaction in cementless total hip replacement. Orthopedics Int 1: , Hukkanen M, Konttinen YT, Santavirta S, Paavolainen P, Gu XH, Terenghi G, Polak JM: Rapid proliferation of calcitonin gene-related peptide-immunoreactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodelling. Neuroscience 54: , 1993

11 185. Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee H-M, Golub LM, Hall J, Simon S: Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase. Antimicrobial Agents Chemother 37: , Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K: Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis. Oral Microbiol Immunol 8: , Santavirta S, Turunen V, Ylinen P, Konttinen YT, Tallroth K: Foot and ankle fusions in Charcot- Marie-Tooth disease. Arch Orthop Traum Surg 112: , Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum KB, Braga S, Coll J, De Vita S, Drosos AA, Ehrenfeld M, Hatron PY, Hay EM, Isenberg DA, Janin A, Kalden JR, Kater L, Konttinen YT, Maddison PJ, Maini RN, Manthorpe R, Meyer O, Ostuni P, Pennec Y, Prause JU, Richards A, Sauvezie B, Schiødt M, Sciuto M, Scully C, Shoenfeld Y, Skopouli FN, Smolen JS, Snaith ML, Tishler M, Todesco S, Valesini G, Venables PJ W, Wattiaux MJ, Youinou P. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 36: , Aro T, Kanerva L, Häyrinen-Immonen R, Konttinen YT, Silvennoinen-Kassinen S, Jolanki R, Estlander T: Long-lasting allergic patch test reaction caused by gold. Contact Dermatitis 28: , Santavirta S, Nordström D, Metsärinne K, Konttinen YT: Biocompatibility of polyethylene and host response to loosening of cementless total hip replacement. Clin Orthop Rel Res 297: , Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT: The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases. Arthritis Rheum 36: , Grönblad M, Nykänen J, Konttinen Y, Järvinen E, Helve T: Effect of zopiclone on sleep quality, morning stiffness, widespread tenderness and pain and general discomfort in primary fibromyalgia patients. A double-blind randomized trial. Clin Rheumatol 12: , Lauhio A, Konttinen YT, Salo T, Tschesche H, Lähdevirta J, Woessner F Jr, Golub LM, Sorsa T: Placebo-controlled study of the effects of three-month lymecycline treatment on serum matrix metalloproteinases in reactive arthritis. Ann NY Acad Sci 732: , Salo T, Sorsa T, Lauhio A, Konttinen YT, Ainamo A, Kjeldsen L, Borregaard N, Ranta H, Lähdevirta J: Matrix metalloproteinases, their endogenous inhibitors and microbial activators in gingival crevicular fluid and saliva of HIV (+)-subjects. Ann NY Acad Sci 732: , Konttinen YT, Häyrinen-Immonen R, Nordström D, Malmström MJ, Hukkanen M, Sorsa T, Polak JM: Innervation of recurrent aphthous ulcers. Oral Microbiol Immunol 9:60-64, Nordström D, Santavirta S, Antti-Poika I, Konttinen YT: Local immune-inflammatory response to infected total hip and knee replacements. Arch Orthop Trauma Surg 113: , Törnwall J, Uusitalo H, Konttinen YT: The distribution and origin of nerve fibers immunoreactive for substance P and neurokinin A in the anterior buccal gland of the rat. Cell Tissue Res 277: , Ingman T, Sorsa T, Lindy O, Koski H, Konttinen YT: Multiple forms of gelatinases / type IV collagenases in saliva and gingival crevicular fluid of periodontitis patients. J Clin Periodontol 21:26-31, Törnwall J, Uusitalo H, Hukkanen M, Sorsa T, Konttinen YT: Distribution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjögren's syndrome and in normal controls. Clin Exp Rheumatol 12: , Santavirta N, Lillqvist G, Sarvimäki A, Honkanen V, Konttinen YT, Santavirta S: Teaching of patients undergoing total hip replacement surgery. Int J Nurs Stud 31: , Ingman T, Könönen M, Konttinen YT, Siirilä HS, Suomalainen K, Sorsa T: Collagenase, gelatinase and elastase activities in sulcular fluid of osteointegrated implants and natural teeth. J Clin Periodontol 21: , Nordsletten L, Madsen JE, Almaas R, Rootwelt T, Halse J, Konttinen YT, Hukkanen M, Santavirta S: The neuronal regulation of fracture healing. Effects of sciatic nerve resection in rat tibia. Acta Orthop Scand 65: , 1994

12 203. Konttinen YT, Kangaspunta P, Lindy O, Takagi M, Sorsa T, Segerberg M, Tschesche H, Eisen AZ: Collagenase in Sjögren's syndrome. Ann Rheum Dis 53: , Lauhio A, Konttinen YT, Tschesche H, Nordström D, Salo T, Lähdevirta J, Golub LM, Sorsa T: Reduction of matrix metalloproteinase-8 neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis. Antimicrobial Agents Chemother 38: , Häyrinen-Immonen R, Sorsa T, Pettilä J, Konttinen YT, Teronen O, Malmström M: Effect of tetracyclines on collagenase activity in patients with recurrent aphthous ulcers. J Oral Pathol Med 23: , Lauhio A, Konttinen YT, Salo T, Tschesche H, Nordström D, Lähdevirta J, Golub LM, Sorsa T: The in vivo effect of doxycycline treatment on matrix metalloproteinases in reactive arthritis. Ann NY Acad Sci 732: , Ingman T, Sorsa T, Kangaspunta P, Konttinen YT: Elastase and α1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis. J Periodontol 65: , Ingman T, Sorsa T, Michaelis J, Konttinen YT: Immunohistochemical study of neutrophil- and fibroblast-type collagenases and stromelysin-1 in adult periodontitis. Scand J Dent Res 102: , Nordström D, Santavirta S, Seitsalo S, Hukkanen M, Polak JM, Nordsletten L, Konttinen YT: Symptomatic lumbal spondylolysis: neuroimmunological studies. Spine 19: , Takagi M, Konttinen YT, Santavirta S, Sorsa T, Eisen AZ, Nordsletten L, Suda A: Extracellular matrix metalloproteinases around loose total hip prosthesis. Acta Orthop Scand 65: , Sepper R, Konttinen YT, Sorsa T, Koski H: Gelatinolytic and type IV collagenolytic activity in bronchiectasis. Chest 106: , Luukko M, Konttinen YT, Kemppinen P, Pertovaara A: Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rats. Exp Neurol 128:1-12, Takagi M, Konttinen YT, Lindy O, Sorsa T, Kurvinen H, Suda A, Santavirta S: Gelatinase / type IV collagenases in the loosening of total hip replacement endoprosthesis. Clin Orthop Rel Res 306: , Ding Y, Liede K, Leppä S, Ingman T, Sepper R, Konttinen YT, Sorsa T: Gingival crevicular fluid and salivary matrix metalloproteinases of heavy smokers as indicators of periodontal health. Ann NY Acad Sci 732: , Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT: Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases. Ann NY Acad Sci 732: , Lauhio A, Salo T, Ding Y, Konttinen YT, Nordström D, Tschesche H, Lähdevirta J, Golub LM, Sorsa T: In vivo inhibition of human neutrophil collagenase (MMP-8) activity during long-term combination therapy of doxycycline and non-steroidal anti-inflammatory drugs (NSAID) in acute reactive arthritis. Clin Exp Immunol 98:21-28, Baudet-Pommel M, Albuisson E, Kemeny JL, Falvard F, Ristori JM, Fraysse MP, Sauvezie B, Vitali C, Bombardieri S, Bencivelli W, de Vita S, Sciuto M, Moutsopoulos HM, Drosos AA, Skopouli FN, Balestrieri G, Braga S, Bernstein RM, Hay EM, Bjerrum KB, Prause JU, Schiodt M, Coll J, Ehrenfeld M, Shoenfeld Y, Hatron PY, Janin A, Isenberg DA, Snaith ML, Maini RN, Venables PJW, Kalden JR, Kater L, Konttinen YT, Maddisson PJ, Manthorpe R, Meyer O, Wattiaux MJ, Ostuni P, Todesco S, Pennec Y, Youinou P, Richards A, Scully C, Sauvezie B, Smolen JS, Tishler M, Valesini G: Early dental loss in Sjögren s syndrome. Histologic correlates. Oral Surg Oral Med Oral Pathol 78: , Vitali C, Moutsopoulos HM, Bombardieri S, and the European Community Study Group on Diagnostic Criteria for Sjögren's Syndrome: Sensitivity and specificity of tests for ocular and oral involvement in Sjögren's syndrome. Ann Rheum Dis 53: , Takagi M, Konttinen YT, Kemppinen P, Sorsa T, Tschesche H, Bläser J, Suda A, Santavirta S: Tissue inhibitor of metalloproteinase 1 and collagenolytic and gelatinolytic activity in loose hip endoprostheses. J Rheumatol 22: , 1995

13 220. Sorsa T, Ding Y, Ingman T, Salo T, Westerlund U, Haapasalo M, Tschesche H, Konttinen YT: Cellular source, activation and inhibition of dental plaque collagenase. J Clin Periodontol 22: , Tervahartiala T, Ingman T, Sorsa T, Ding Y, Kangaspunta P, Konttinen YT: Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjögren's syndrome. Eur J Oral Sci 103:11-16, Takagi M, Konttinen YT, Santavirta S, Kangaspunta P, Sorsa T, Suda A, Rokkanen P: Cathepsin G and α1-antitrypsin in the local host reaction to loosening of total hip prosthesis. J Bone Joint Surg (Am) 77A:16-25, Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L, Madsen JE, Almaas R, Oestreicher AB, Rootwelt T, Polak JM: Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus. Clin Orthop Rel Res 311: , Takagi M, Konttinen YT, Santavirta S, Kangaspunta P, Sorsa T, Yamakawa M, Suda A: Elastase activity, uninhibited by α1-antitrypsin, in the periprosthetic connective tissue matrix around loose total hip prostheses. J Orthopaed Res 13: , Golub LM, Sorsa T, Lee H-M, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT: Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 22: , Sepper R, Konttinen YT, Ingman T, Sorsa T: Presence, activitites, and molecular forms of cathepsin G, elastase, α1-antitrypsin and α1-antichymotrypsin in bronchiectasis. J Clin Immunol 15:27-34, Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T: Human neutrophil collagenase (MMP-8), identified in bronciectasis BAL fluid, correlates with severity of disease. Chest 107: , Teronen O, Salo T, Konttinen YT, Rifkin B, Vernillo A, Ramamurthy NS, Kjeldsen L, Borregaard N, Hietanen J, Sorsa T: Identification and characterization of gelatinases/type IV collagenases in jaw cysts. J Oral Pathol Med 24:78-84, Nordström D, Honkanen VEA, Nasu Y, Antila E, Friman C, Konttinen YT: Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 14: , Teronen O, Salo T, Laitinen J, Törnwall J, Ylipaavalniemi P, Konttinen YT, Hietanen J, Sorsa T: Characterization of interstitial collagenases in jaw cyst wall. Eur J Oral Sci 103: , Sukura A, Konttinen YT, Sepper R, Lindberg L-A: Recovery from Pneumocystis carinii pneumonia in dexamethasone-treated Wistar rats. Eur Respir J 8: , Sukura A, Konttinen YT, Sepper R, Kaartinen L, Sorsa T, Lindberg L-A: Collagenases and serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia. J Clin Microbiol 33: , Kilpi A, Rich AM, Konttinen YT, Reade PC: The expression of c-erbb2 protein in the keratinocytes of oral mucosal lichen planus. Brit J Dermatol 133: , Koski H, Konttinen YT, Xu-Hong G, Hietanen J, Malmström M: Transforming growth factor β2 in labial salivary glands in Sjögren's syndrome. Ann Rheum Dis 54: , Törnwall J, Konttinen YT, Hietanen J, Sorsa T, Hukkanen M, Uusitalo H: VIP in salivary glands in Sjögren's syndrome. Brit J Rheumatol 34: , Ding Y, Uitto V-J, Firth J, Salo T, Haapasalo M, Konttinen YT, Sorsa T: Modulation of matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases. Oral Dis 1: , Törnwall J, Konttinen YT, Uusitalo H: Immunohistochemical distribution of calcitonin generelated peptide in nerve fibers of the anterior buccal gland of the rat. Histochem J 28:1-5, Nordsletten L, Buø L, Takagi M, Konttinen YT, Yamakawa M, Santavirta S, Aasen AO: The plasminogen activation system is upregulated in loosening of total hip prostheses. Acta Orthop Scand 67: , Tervahartiala T, Konttinen YT, Ingman T, Häyrinen-Immonen R, Ding Y, Sorsa T: Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis. J Clin Periodontol 23:68-75, Nordström D, Lindy O, Konttinen YT, Lauhio A, Sorsa T, Friman C, Pettersson T, Santavirta S: Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis. Clin Rheumatol 15:35-41, 1996

14 241. Solovieva SA, Čeponis A, Konttinen YT, Takagi M, Suda A, Eklund KK, Sorsa T, Santavirta S: Mast cells in loosening of totally replaced hips. Clin Orthop Rel Res 322: , Konttinen YT, Kurvinen H, Takagi M, Michelsson J-E, Eklund KK, Nordsletten L, Buø L, Aasen AO, Santavirta S: IL-1 and collagenases around loosening total hip prosthesis. Clin Exp Rheumatol 14: , Santavirta S, Čeponis A, Solovieva SA, Hurri H, Jin J, Takagi M, Suda A, Konttinen YT: Periprosthetic microvasculature in loosening of total hip replacement. Arch Orthop Traum Surg 115: , Čeponis A, Konttinen YT, Mackevičius Z, Solovieva SA, Hukkanen M, Tamulaitienė M, Matulis A, Santavirta S: Aberrant vascularity and von Willebrand factor distribution in inflamed synovial membrane. J Rheumatol 23: , Westerlund U, Ingman T, Lukinmaa P-L, Salo T, Kjeldsen L, Borregaard N, Tjäderhane L, Konttinen YT, Sorsa T: Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis. J Dent Res 75: , Santavirta N, Björvell H, Koivumäki E, Hurskainen K, Solovieva S, Konttinen YT: The factor structure of coping strategies in hemophilia. J Psychosom Res 40: , Santavirta N, Björvell H, Konttinen YT, Solovieva S, Poussa M, Santavirta S: Sense of coherence and outcome of anterior low-back fusion. A 5 to 13-year follow-up of 85 patients. Arch Orthop Trauma Surg 115: , Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane D, Konttinen YT, Sorsa T: Matrix metalloproteinases and their tissue inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 23: , Teronen O, Salo T, Hietanen J, Eklund KK, Sommerhoff CP, Sorsa T, Konttinen YT: Mast cellderived tryptase in odontogenic cysts. J Oral Pathol Med 25: , Santavirta N, Björvell H, Solovieva S, Santavirta S, Hurskainen K, Konttinen YT: Empirically derived classification of coagulation disorders in 224 patients. Haematologica 81: , Immonen I, Konttinen YT, Sorsa T, Tommila P, Sirén V: Proteinases in subretinal fluid. Graef Arch Clin Exp Ophthal 234: , Mellanen L, Ingman T, Lähdevirta J, Lauhio A, Ainamo A, Konttinen YT, Sukura A, Salo T, Sorsa T: Matrix metalloproteinases -1, -3 and -8 and myeloperoxidase in saliva of patients with human immunodeficiency virus infection. Oral Dis 2: , Ding Y, Uitto V-J, Haapasalo M, Lounatmaa K, Konttinen YT, Salo T, Grenier D, Sorsa T: Membrane components of Treponema denticola trigger proteinase release from human polymorphonuclear leukocytes. J Dent Res 75: , Santavirta S, Takagi M, Konttinen YT, Sorsa T, Suda A: Inhibitory effect of cephalothin on matrix metalloproteinase activity around loose hip prostheses. Antimicrobial Agents Chemother 40: , Nordsletten L, Høgåsen AKM, Konttinen YT, Santavirta S, Aspenberg P, Aasen AO: Human monocytes stimulation by particles of hydroxyapatite, silicon carbide and diamond: in vitro studies of new prosthesis coatings. Biomaterials 17: , Weckroth M, Vaheri A, Lauharanta J, Sorsa T, Konttinen YT: Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers. J Invest Dermatol 106: , Nordström D, Konttinen YT, Solovieva SA, Friman C, Santavirta S: In- and out-patient rehabilitation in rheumatoid arthritis. A controlled, open, longitudinal, cost-effectiveness study. Scand J Rheumatol 25: , Konttinen YT, Törnwall J, Kemppinen P, Uusitalo H, Sorsa T, Hukkanen M, Polak JM: Neutral endopeptidase (EC ) in labial salivary glands in healthy controls and in patients with Sjögren's syndrome. Ann Rheum Dis 55: , Xu J-W, Konttinen YT, Lassus J, Natah S, Čeponis A, Solovieva S, Aspenberg P, Santavirta S: Tumor necrosis factor-alpha (TNF-α) in loosening of total hip replacement (THR). Clin Exp Rheumatol 14: , Vitali C, Bombardieri S, Moutsopoulos HM, Coll J, Gerli R, Hatron PY, Kater L, Konttinen YT, Manthorpe R, Meyer O, Mosca M, Ostuni P, Pellerito RA, Pennec Y, Porter SR, Richards A, Sauvezie B, Schiødt M, Sciuto M, Shoenfeld Y, Skopouli FN, Smolen JS, Soromenho F, Tishler M, Tomsic M, van de Merwe JP, Yeoman CM, Wattiaux MJ. Assessment of the European

15 classification criteria for Sjögren's syndrome in a series of clinically defined cases: results of a prospective multicentre study. Ann Rheum Dis 55: , Konttinen YT, Čeponis A, Meri S, Vuorikoski A, Kortekangas P, Sorsa T, Sukura A, Santavirta S: Complement in acute and chronic arthritides. Assessment of C3c, C9 and protectin (CD59) in synovial membrane. Ann Rheum Dis 55: , Kilpi A, Rich AM, Konttinen YT, Reade PC: Expression of c-erbb-2 protein in keratinocytes of oral mucosal lichen planus and subsequent squamous cell carcinoma. Eur J Oral Sci 104: , Waris V, Xu JW, Nordsletten L, Sorsa T, Santavirta S, Konttinen YT: Basic fibroblast growth factor (bfgf) in the synovial-like membrane around loose total hip prostheses. Scand J Rheumatol 25: , Xu JW, Konttinen YT, Waris V, Barrena EG, Sorsa T, Santavirta S: Granulocyte-macrophage colony stimulating factor in the aseptic loosening of total hip arthroplasty. J Orthop Rheumatol 9: , Kilpi A, Rich AM, Reade PC, Konttinen YT: Studies of the inflammatory process and malignant potential of oral mucosal lichen planus. Aust Dent J 41:87-90, Kauppi M, Sakaguchi M, Konttinen YT, Hämäläinen M, Hakala M: Pathogenetic mechanism and prevalence of the stable atlantoaxial subluxation in rheumatoid arthritis. J Rheumatol 23: , Madsen JE, Aune AK, Falch JA, Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L: Neural involvement in post-traumatic osteopenia: an experimental study in the rat. Bone 18: , Madsen JE, Wang J-S, Hukkanen M, Nordsletten L, Konttinen YT, Santavirta S, Polak JM, Aspenberg P: Sensory nerve ingrowth during bone graft incorporation in the rat. Acta Orthop Scand 67: , Halinen S, Sorsa T, Ding Y, Ingman T, Salo T, Konttinen YT, Saari H: Characterization of matrix metalloproteinase (MMP-8 and -9) activities in the saliva and in gingival crevicular fluid of children with Down s syndrome. J Periodontol 67: , Aspenberg P, Anttila A, Konttinen YT, Lappalainen R, Goodman SB, Nordsletten L, Santavirta S: Benign response to particles of diamond and SiC: bone chamber studies of new joint replacement coating materials in rabbits. Biomaterials 17: , Xu JW, Konttinen YT, Waris V, Pätiälä H, Sorsa T, Santavirta S: Macrophage-colony stimulating factor (M-CSF) is increased in the synovial-like membrane of the periprosthetic tissues in the aseptic loosening of total hip replacement (THR). Clin Rheumatol 16: , Saari H, Halinen S, Ganlöv K, Sorsa T, Konttinen YT: Salivary mucous glycoprotein MG1 in Sjögren's syndrome. Clin Chim Acta 259:83-96, Santavirta N, Konttinen YT, Törnwall J, Segerberg M, Santavirta S, Matucci-Cerinic M, Björvell H: Neuropeptides of the autonomic nervous system in Sjögren's syndrome. Ann Rheum Dis 56: , Koivunen A-L, Maisi P, Konttinen YT, Sandholm M: Gelatinolytic activity in tracheal aspirates of horses with chronic pulmonary disease. Acta Vet Scand 38:17-27, Sepper S, Konttinen YT, Buø L, Eklund KK, Lauhio A, Sorsa T, Tschesche H, Aasen AO, Sillastu H: Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (prommp-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo. Eur Respir J 10: , Virtanen T, Konttinen YT, Honkanen N, Härkönen M, Tervo T: Tear fluid plasmin activity of dry eye patients with Sjögren's syndrome. Acta Ophthalmol Scand 75: , Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T: Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate. J Dent Res 76: , Konttinen YT, Waris V, Xu JW, Jiranek WA, Sorsa T, Virtanen I, Santavirta S: Transforming growth factor-β 1 and 2 in the synovial-like membrane between the implant and bone in loosening of total hip arthroplasty. J Rheumatol 24: , Koski H, Konttinen YT, Hietanen J, Tervo T, Malmström M: Epidermal growth factor, transforming growth factor-α, and epidermal growth factor receptor in labial salivary glands in Sjögren's syndrome. J Rheumatol 24: , 1997

16 280. Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Valleala H, Sorsa T: Inhibition of matrix metalloproteinase-1 by dichloromethylene bisphosphonate (clodronate). Calcified Tissue Int 61:59-61, Sorsa T, Salo T, Koivunen E, Tyynelä J, Konttinen YT, Bergmann U, Tuuttila A, Niemi E, Teronen O, Heikkilä P, Tschesche H, Leinonen J, Osman S, Stenman U-H: Activation of type IV procollagenases by human tumor-associated trypsin-2. J Biol Chem 272: , Koivunen A-L, Maisi P, Konttinen YT, Prikk K, Sandholm M: Collagenolytic activity and its sensitivity to doxycycline inhibition in tracheal aspirates of horses with chronic obstructive pulmonary disease. Acta Vet Scand 38:9-16, Konttinen YT, Platts LAM, Tuominen S, Eklund KK, Santavirta N, Törnwall J, Sorsa T, Hukkanen M, Polak JM: Role of nitric oxide in Sjögren's syndrome. Arthritis Rheum 40: , Lindy O, Konttinen YT, Sorsa T, Ding Y, Santavirta S, Čeponis A, López-Otín C: Matrix metalloproteinase 13 (collagenase-3) in human rheumatoid synovium. Arthritis Rheum 40: , Imai S, Tokunaga Y, Konttinen YT, Maeda T, Hukuda S, Santavirta S: Ultrastructure of the synovial sensory peptidergic fibers is distinctively altered in different phases of adjuvant induced arthritis in rats: ultramorphological characterization combined with morphometric and immunohistochemical study for substance P, calcitonin gene related peptide, and protein gene product 9.5. J Rheumatol 24: , Imai S, Konttinen YT, Tokunaga Y, Maeda T, Hukuda S, Santavirta S: An ultrastructural study of calcitonin gene-related peptide-immunoreactive nerve fibers innervating the rat posterior longitudinal ligament. A morphologic basis for their possible efferent actions. Spine 22: , Imai S, Konttinen YT, Tokunaga Y, Maeda T, Hukuda S, Santavirta S: Tyrosine hydroxylaseimmunoreactive nerve fibres in rat posterior longitudinal ligament. J Autonom Nerv Syst 63:51-60, Hukkanen M, Corbett SA, Batten J, Konttinen YT, McCarthy I, Santavirta S, Hughes SPF, Polak JM: Aseptic loosening of total hip replacement: macrophage expression of inducible nitric oxide synthase and cycloo-xygenase-2, together with peroxynitrite formation, as a possible mechanism for early prosthesis failure. J Bone Joint Surg (Br) 79: , Imai S, Rauvala H, Konttinen YT, Tokunaga T, Maeda T, Hukuda S, Santavirta S: Efferent targets of osseous CGRP-immunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat: an ultramorphological study on their terminal-target relations. J Bone Miner Res 12: , Törnwall J, Konttinen YT, Tuominen RK, Törnwall M: Protein kinase C expression in salivary gland acinar epithelial cells in Sjögren s syndrome. Lancet 349: , Hanemaaijer R, Sorsa T, Konttinen YT, Ding Y, Sutinen M, Visser H, van Hinsbergh VWM, Helaakoski T, Kainulainen T, Rönkä H, Tschesche H, Salo T: Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-α and doxycycline. J Biol Chem 272: , Natah SS, Häyrinen-Immonen R, Hietanen J, Malmström M, Konttinen YT: Factor XIIIa-positive dendrocytes are increased in number and size in recurrent aphthous ulcers (RAU). J Oral Pathol Med 26: , Wilkman TSE, Hietanen JHP, Malmström MJ, Konttinen YT: Immunohistochemical analysis of the oncoprotein c-erbb-2 expression in oral benign and malignant lesions. Int J Oral Maxillofac Surg, 27: , Santavirta S, Xu JW, Hietanen J, Čeponis A, Sorsa T, Kontio R, Konttinen YT: Activation of periprosthetic connective tissue in aseptic loosening of total hip replacements. Clin Orthop Rel Res, 352:16-24, Mellanen L, Salo T, Ingman T, Konttinen YT, Lähdevirta J, Sorsa T: 72-kD and 92-kD gelatinases in saliva of patients with human immunodeficiency virus infection. Acta Odont Scand 56: , Natah S, Häyrinen-Immonen R, Hietanen J, Malmström M, Larsson Å, Konttinen YT: Quantitative assessment of mast cells in recurrent aphthous ulcers (RAU). J Oral Pathol Med 27: , 1998

17 297. Natah SS, Hietanen J, Häyrinen-Immonen R, Jungell P, Malmström M, Konttinen YT: Expression of cell proliferation-associated nuclear antigen (Ki-67) in recurrent aphthous ulcers (RAU). Oral Med Pathol 3:29-34, Xu JW, Konttinen YT, Li TF, Waris V, Lassus J, Matucci-Cerinic M, Sorsa T, Santavirta S: Production of platelet-derived growth factor in aseptic loosening of total hip replacement. Rheumatol Int 17: , Čeponis A, Konttinen YT, Imai S, Tamulaitienė M, Li T-F, Xu J-W, Hietanen J, Santavirta S, Fassbender HG: Synovial lining, endothelial and inflammatory mononuclear cell proliferation in synovial membranes in psoriatic and reactive arthritis: a comparative quantitative morphometric study. Brit J Rheumatol 37: , Konttinen YT, Li T-F, Michelsson O, Xu J-W, Sorsa T, Santavirta S, Imai S, Virtanen I: Expression of tenascin-c in aseptic loosening of total hip replacement. Ann Rheum Dis 57: , Ohnishi K, Takagi M, Kurokawa Y, Satomi S, Konttinen YT: Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 78: , Čeponis A, Konttinen YT, Takagi M, Xu J-W, Sorsa T, Matucci-Cerinic M, Santavirta S, Bankl H- C, Valent P: Expression of stem cell factor (SCF) and SCF receptor (c-kit) in synovial membrane in arthritis: correlation with synovial mast cell hyperplasia and inflammation. J Rheumatol 25: , Nordström D, Lindy O, Lauhio A, Sorsa T, Santavirta S, Konttinen YT: Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis. Rheumatol Int 17: , Santavirta S, Takagi M, Nordsletten L, Anttila A, Lappalainen R, Konttinen YT: Biocompatibility of silicon carbide in colony formation test in vitro. A promising new ceramic THR implant coating material. Arch Orthop Trauma Surg 118:89-91, Imai S, Konttinen YT, Jumppanen M, Lindy O, Čeponis A, Kemppinen P, Sorsa T, Santavirta S, Xu J-W, Lopéz-Otín C: High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign body reaction. J Bone Joint Surg (Br) 80-B: , Konttinen YT, Čeponis A, Takagi M, Ainola M, Sorsa T, Sutinen M, Salo T, Ma J, Santavirta S, Seiki M: New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above. Matrix Biol 17: , Sorsa T, Ramamurthy NS, Vernillo AT, Zhang X, Konttinen YT, Rifkin BR, Golub LM: Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases. J Rheumatol 25: , Konttinen YT, Halinen S, Hanemaaijer R, Sorsa T, Hietanen J, Čeponis A, Xu J-W, Manthorpe R, Whittington J, Larsson Å, Salo T, Kjeldsen L, Stenman U-H, Eisen AZ: Matrix metalloproteinase (MMP)-9 type IV collagenase/gelatinase implicated in the pathogenesis of Sjögren s syndrome. Matrix Biol 17: , Bjørnland K, Buø L, Scott H, Konttinen YT, Johansen HT, Aasen AO: Polymorphonuclear elastase in human colorectal carcinoma. Int J Oncology 12: , Hanemaaijer R, Visser H, Konttinen YT, Koolwijk P, Verheijen J: A novel and simple immunocapture assay for determination of gelatinase-b (MMP-9) activities in biological fluids: saliva from patients with Sjögren s syndrome contain increased latent and active gelatinase-b levels. Matrix Biol 17: , Hukkanen M, Corbett SA, Platts LAM, Konttinen YT, Santavirta S, Hughes SPF, Polak JM: Nitric oxide in the local host reaction to total hip replacement. Clin Orthop Rel Res 352:53-65, Xu J-W, Li T-F, Partsch G, Čeponis A, Santavirta S, Konttinen YT: Interleukin-11 (IL-11) in aseptic loosening of total hip replacement (THR). Scand J Rheumatol 27: , Matucci-Cerinic M, Generini S, Partsch G, Pignone A, Dini G, Konttinen YT, Del Rosso M: Synoviocytes from osteoarthritis and rheumatoid arthritis produce plasminogen activators and plasminogen activator inhibitor-1 and display u-pa receptors on their surface. Life Sci 63: , Takagi M, Santavirta S, Ida H, Ishii M, Akimoto K, Saotome K, Konttinen YT: The membranetype-matrix metalloproteinase/ matrix metalloproteinase-2/ tissue inhibitor of metalloproteinase-2

18 system in periprosthetic connective-tissue remodeling in loose total-hip prostheses. Lab Invest 78: , Sepper R, Konttinen YT, Kemppinen P, Sorsa T. Eklund KK: Mast cells in bronchiectasis. Ann Med 30: , Konttinen YT, Kääpä E, Hukkanen M, Gu X, Takagi M, Santavirta S, Alaranta H, Li TF, Suda A: Cathepsin G in degenerating and healthy discal tissue. Clin Exp Rheumatol 17: , Arborelius M Jr, Konttinen YT, Nordström DC, Solovieva SA: Gly-X-Y repeat sequences in the treatment of active rheumatoid arthritis. Rheumatol Int 18: , Nordström D, Santavirta S, Aho A, Heikkilä J, Teppo AM, Konttinen YT: Immune responses to osteoarticular allografts of the knee - cytokine studies. Arch Orthop Trauma Surg 119: , Vujisić S, Stefanović V, Kupešić S, Kurjak A, Lackovic G, Koski H, Konttinen YT: Immunohistochemical localization of epidermal growth factor and its receptor in differently mature endometrium of mid-luteal phase. Periodicum biologorum 101:65-70, Konttinen YT, Kemppinen P, Koski H, Li T-F, Jumppanen M, Hietanen J, Santavirta S, Salo T, Larsson Å, Hakala M, Sorsa T: TH1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals. Scand J Rheumatol 28: , Koivunen E, Arap W, Valtanen H, Rainisalo A, Medina OP, Heikkilä P, Kantor C, Gahmberg CG, Salo T, Konttinen YT, Sorsa T, Ruoslahti E, Pasqualini R: Tumor targeting with a selective gelatinase inhibitor. Nature Biotechnology 17: , Konttinen YT, Kemppinen P, Li T-F, Waris E, Pihlajamäki H, Sorsa T, Takagi M, Santavirta S, Schultz GS, Humphreys-Beher MG: Transforming and epidermal growth factors in degenerated intervertebral discs. J Bone Joint Surg (Br) 81-B: , Takei I, Takagi M, Konttinen YT, Santavirta S, Ida H, Hamasaki M, Ishii M, Fukushima S, Ogino T: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in joint fluid of the patients with loose artificial hip joints J Biomed Mater Res 45: , Laine J, Konttinen YT, Beliaev N, Happonen R-P: Immunocompetent cells in amalgam-associated oral lichenoid contact lesions. J Oral Pathol Med 28: , Tulikoura I, Lassus J, Konttinen YT, Juutilainen T, Santavirta S: A safe surgical technique for the partial resection of the ruptured spleen. A clinical report. Injury 30: , Konttinen YT, Salo T, Hanemaaijer R, Valleala H, Sorsa T, Sutinen M, Čeponis A, Xu J-W, Santavirta S, Teronen O, López-Otín C: Collagenase-3 (MMP-13) and its activators in rheumatoid arthritis: localization in the pannus - hard tissue junction and inhibition by alendronate. Matrix Biol 18: , Čeponis A, Hietanen J, Tamulaitienė M, Partsch G, Pätiälä H, Konttinen YT: A comparative quantitative morphometric study of cell apoptosis in syovial membranes in psoriatic, reactive and rheumatoid arthritis. Rheumatology 38: , Konttinen YT, Li T-F, Xu J-W, Takagi M, Pirilä L, Silvennoinen T, Santavirta S, Virtanen I: Expression of laminins and their integrin receptors in different conditions of synovial membrane and synovial membrane-like interface tissue. Ann Rheum Dis 58: , Santavirta S, Lappalainen R, Pekko P, Anttila A, Konttinen YT: The counterface, surface smoothness, tolerances and coatings in total joint prostheses. Clin Orthop Rel Res 369:92-102, Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, López-Otín C, Takagi M: Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 58: , Li T-F, Santavirta S, Virtanen I, Könönen M, Takagi M, Konttinen YT: Increased expression of EMMPRIN in the tissue around loosened hip prostheses. Acta Orthop Scand 70: , De Bernabé DB, Peterson P, Luopajärvi K, Matintalo P, Alho A, Konttinen Y, Krohn K, de Córdoba SR, Ranki A: Mutational analysis of the HGO gene in Finnish alkaptonuria patients. J Med Genet 36: , Anttila A, Lappalainen R, Heinonen H, Santavirta S, Konttinen YT: Superiority of diamondlike carbon coating on articulating surfaces of artificial hip joint. New Diamond and Frontier Carbon Technology 9: , 1999

19 334. Konttinen YT, Hietanen J, Virtanen I, Ma J, Sorsa T, Xu J-W, Williams NP, Manthorpe R, Janin A: Mast cell derangement in salivary glands in patients with Sjögren's syndrome. Rheumatol Int 19: , Teronen O, Laitinen M, Salo T, Hanemaaijer R, Heikkilä P, Konttinen YT, Sorsa T: Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma (letter). Blood 96: , Konttinen YT, Ramsay H, Hietanen J, Sorsa T, Nordström D: Otitis externa sicca/fibrotising external otitis (FEO) as a complication of Sjögrens syndrome. Clin Exp Rheumatol 18: , Santavirta S, Valtonen M, Pätiälä H, Saarinen O, Konttinen YT: Disseminated hydatid disease causing paraplegia and destruction of the hip. Arch Orthop Trauma Surg 120: , Lassus J, Tulikoura I, Konttinen YT, Santavirta S: Treatment of infection and non-union after bilateral complicated proximal tibial fracture. Ann Chir Gynaecol 89: , Lassus J, Waris V, Xu J-W, Li T-F, Hao J, Nietosvaara Y, Santavirta S, Konttinen YT: Increased interleukin-8 (IL-8) expression is related to aseptic loosening of total hip replacement. Arch Orthop Trauma Surg 120: , Li T-F, Xu J-W, Santavirta S, Nordsletten L, Michelsson O, Takagi M, Virtanen I, Konttinen YT: Distribution of fibronectins and their integrin receptors in interface tissue from aseptic loosening of hip protheses. Clin Exp Rheumatol 18: , Niissalo S, Hietanen J, Malmström M, Hukkanen M, Polak JM, Konttinen YT: Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions. J Oral Pathol Med 29: , Takei I, Takagi M, Santavirta S, Ida H, Ishii M, Ogino T, Ainola M, Konttinen YT: Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints. J Biomed Mater Res 52: , Valleala H, Teronen O, Friman C, Sorsa T, Solovieva SA, Konttinen YT: Inhibition of collagenase by a bisphosphonate-group drug in patients with rheumatoid arthritis. J Rheumatol 27: , Konttinen YT, Li T-F, Mandelin J, Liljeström M, Sorsa T, Santavirta S, Virtanen I: Increased expression of extracellular matrix metalloproteinase inducer in rheumatoid synovium. Arthritis Rheum 43: , Xu JW, Ma J, Li TF, Waris E, Alberty A, Santavirta S, Konttinen YT: Expression of epidermal growth factor and transforming growth factor α in interfacial membranes retrieved at revision total hip arthroplasty. Ann Rheum Dis 59: , Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT: Collagenases in different categories of peri-implant vertical bone loss. J Dent Res 79: , Collin HL, Sorsa T, Meurman JH, Niskanen L, Salo T, Rönkä H, Konttinen YT, Koivisto AM, Uusitupa M: Salivary matrix metalloproteinase (MMP-8) levels and gelatinase (MMP-9) activities in patients with type 2 diabetes mellitus. J Periodontal Res 35: , Takei I, Takagi M, Ida H, Ogino T, Santavirta S, Konttinen YT: High macrophage-colony stimulating factor levels in synovial fluid of loose artificial hip joints. J Rheumatol 27: , Li TF, Xu JW, Santavirta S, Takagi M, Virtanen I, Pirilä L, Konttinen YT: Expression of vitronectin and its integrin receptors in the synovial membrane-like interface tissue from aseptic loosening of total hip replacement. J Rheumatol 27: , Hokynar K, Brunstein J, Söderlund-Venermo M, Kiviluoto O, Partio EK, Konttinen Y, Hedman K: Integrity and full coding sequence of B19 virus DNA persisting in human synovial tissue. J Virol Genet 81: , Li TF, Waris V, Ma J, Lassus J, Yoshida T, Santavirta S, Virtanen I, Konttinen YT: Distribution of tenascin-x in different synovial samples and synovial membrane-like interface tissue from aseptic loosening of total hip replacement. Rheumatol Int 19: , Kääpä E, Wang W, Takala TE, Poussa M, Konttinen YT, Lammi MJ, Vanharanta H: Elevated protein content and prolyl 4-hydroxylase activity in severely degenerated human annulus fibrosus. Connect Tissue Res 41:93-99, 2000

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